- Jul 2018
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europepmc.org europepmc.org
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On 2016 Oct 18, Erick H Turner commented:
The ClinicalTrials.gov entry for this study (https://www.clinicaltrials.gov/ct2/show/record/NCT01584440?term=NCT01584440&rank=1) contains the original registration information, but as of October 2016, study results have still not been posted. Credibility of the published results would be enhanced by doing so.
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On 2015 Nov 30, Geriatric Medicine Journal Club commented:
This article was critically appraised at the November 2015 Geriatric Medicine Journal Club (follow #GeriMedJC on Twitter). Concerns discussed included that the trial was funded by pharma, last-observation carried forward is not a recommended method for imputing missing data in dementia trials, biases introduced by the choice of rescue medication (Lorazepam), agitation in this trial lumped together several different behaviours (verbal aggression, physical aggression, and non-aggressive activity), and mode of action of the medications. Nevertheless, the findings are interesting but perhaps not quite ready for wide adoption. A transcript of the full discussion can be found at: http://gerimedjc.blogspot.com/2015/11/dextromethorphan-quinidine-not-quite.html?spref=tw
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2015 Nov 30, Geriatric Medicine Journal Club commented:
This article was critically appraised at the November 2015 Geriatric Medicine Journal Club (follow #GeriMedJC on Twitter). Concerns discussed included that the trial was funded by pharma, last-observation carried forward is not a recommended method for imputing missing data in dementia trials, biases introduced by the choice of rescue medication (Lorazepam), agitation in this trial lumped together several different behaviours (verbal aggression, physical aggression, and non-aggressive activity), and mode of action of the medications. Nevertheless, the findings are interesting but perhaps not quite ready for wide adoption. A transcript of the full discussion can be found at: http://gerimedjc.blogspot.com/2015/11/dextromethorphan-quinidine-not-quite.html?spref=tw
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY. -
On 2016 Oct 18, Erick H Turner commented:
The ClinicalTrials.gov entry for this study (https://www.clinicaltrials.gov/ct2/show/record/NCT01584440?term=NCT01584440&rank=1) contains the original registration information, but as of October 2016, study results have still not been posted. Credibility of the published results would be enhanced by doing so.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
-