On 2016 Aug 26, Brandon Horn commented:

The phagocytic function of neutrophils is decreased significantly with the addition of glucose (PMID:4748178). Dextrose (the "placebo") is simply D-glucose. This would compromise patients' immunological function: a highly relevant effect given the outcome measure of this study. Therefore, dextrose is an inappropriate "placebo" and essentially invalidates the conclusions of the study. See PMC:3137704 for a discussion of the improper use of sham control groups.

On 2016 Aug 26, Brandon Horn commented:

The phagocytic function of neutrophils is decreased significantly with the addition of glucose (PMID:4748178). Dextrose (the "placebo") is simply D-glucose. This would compromise patients' immunological function: a highly relevant effect given the outcome measure of this study. Therefore, dextrose is an inappropriate "placebo" and essentially invalidates the conclusions of the study. See PMC:3137704 for a discussion of the improper use of sham control groups.