2 Matching Annotations
- Jul 2018
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europepmc.org europepmc.org
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On 2016 Jan 28, Atanas G. Atanasov commented:
Whereby known or predicted usefulness of the synthesized molecules is lately a major driving factor dictating whether chemical synthesis projects are financed or not by funding bodies, it is still important to consider that generation of new chemical molecules might also lead to a following discovery of physical, chemical, or biological properties that are not possible to be predicted in advance. Therefore, new structure synthesis could also be seen as a tool for “exploring the unknown”, which might later lead to unpredictable but very beneficial expansion of existing knowledge. In the context of drug discovery, for example, screening approaches can lead to the discovery of new pharmacological activities of chemical structures that were previously generated without knowledge for possible effects on the biological target molecules that are later found to be affected (e.g., a recent example from this journal: Huang et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699).
Atanas G. Atanasov http://pharmakognosie.univie.ac.at/people/atanasov-atanas-g/ http://homepage.univie.ac.at/atanas.atanasov/ http://about.me/Atanas_At
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
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On 2016 Jan 28, Atanas G. Atanasov commented:
Whereby known or predicted usefulness of the synthesized molecules is lately a major driving factor dictating whether chemical synthesis projects are financed or not by funding bodies, it is still important to consider that generation of new chemical molecules might also lead to a following discovery of physical, chemical, or biological properties that are not possible to be predicted in advance. Therefore, new structure synthesis could also be seen as a tool for “exploring the unknown”, which might later lead to unpredictable but very beneficial expansion of existing knowledge. In the context of drug discovery, for example, screening approaches can lead to the discovery of new pharmacological activities of chemical structures that were previously generated without knowledge for possible effects on the biological target molecules that are later found to be affected (e.g., a recent example from this journal: Huang et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699).
Atanas G. Atanasov http://pharmakognosie.univie.ac.at/people/atanasov-atanas-g/ http://homepage.univie.ac.at/atanas.atanasov/ http://about.me/Atanas_At
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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