On 2016 Mar 04, Joe Newton commented:

The absence of established biomarkers does indeed make diagnosis uncertain and this uncertainty applies to other psychiatric anomalies. The missing heritability of gene events predisposing to anomalies can now only be roughly determined. Also there are expected factorial combinations (billions) of epistatic SNPs suggesting similar numbers of distinct diagnoses. See (Mellerup et al. 2004 mania and reentry)(Newton JR 2007 gene ontology)(Kim et al., 2010) (Koefoed et al., 2011) (Mellerup et al., 2012)

The locations-times of: particular regional volumes and dysmyelination extent are suggested places and times to start in finding biomarkers.

My congratulations to the authors.

On 2016 Mar 04, Joe Newton commented:

The absence of established biomarkers does indeed make diagnosis uncertain and this uncertainty applies to other psychiatric anomalies. The missing heritability of gene events predisposing to anomalies can now only be roughly determined. Also there are expected factorial combinations (billions) of epistatic SNPs suggesting similar numbers of distinct diagnoses. See (Mellerup et al. 2004 mania and reentry)(Newton JR 2007 gene ontology)(Kim et al., 2010) (Koefoed et al., 2011) (Mellerup et al., 2012)

The locations-times of: particular regional volumes and dysmyelination extent are suggested places and times to start in finding biomarkers.

My congratulations to the authors.