On 2016 Feb 27, Daniel Corcos commented:

The answer of Welch et al. to Peter Eby is interesting: "Eby posits that the stable incidence of metastatic breast cancer derives from two countervailing trends: a steady increase in underlying (true) breast-cancer incidence and a steady decrease in metastatic-disease incidence resulting from screening. Such perfectly counterbalanced trends would be remarkable. Furthermore, the supposition that the 30% increase in overall incidence reflects true increased disease burden ignores the fact that most of it occurred during the 1980s — as mass screening was introduced. The fact that the increase persists suggests substantial over diagnosis." However, the evidence presented by Eby is clear. So the counterbalanced trends should be explained, which can be done by assuming that mass screening is responsible for the rising incidence of breast cancer. http://www.ncbi.nlm.nih.gov/myncbi/daniel.corcos.1/comments/

On 2016 Feb 27, Daniel Corcos commented:

The answer of Welch et al. to Peter Eby is interesting: "Eby posits that the stable incidence of metastatic breast cancer derives from two countervailing trends: a steady increase in underlying (true) breast-cancer incidence and a steady decrease in metastatic-disease incidence resulting from screening. Such perfectly counterbalanced trends would be remarkable. Furthermore, the supposition that the 30% increase in overall incidence reflects true increased disease burden ignores the fact that most of it occurred during the 1980s — as mass screening was introduced. The fact that the increase persists suggests substantial over diagnosis." However, the evidence presented by Eby is clear. So the counterbalanced trends should be explained, which can be done by assuming that mass screening is responsible for the rising incidence of breast cancer. http://www.ncbi.nlm.nih.gov/myncbi/daniel.corcos.1/comments/