On 2016 Feb 19, David Keller commented:

What about safety?

This study confirms that, in symptomatic male seniors, raising testosterone concentrations from moderately low to the normal midlife range has moderate benefits. Prior studies have yielded similar benefits in similar groups of men. What we are still missing is evidence of safety for this intervention. Specifically, we need to rule out the possibility that exogenous testosterone will increase deaths from atherosclerotic arterial disease, especially heart attacks, or neoplasms, especially prostate cancer.

On 2016 Feb 19, David Keller commented:

What about safety?

This study confirms that, in symptomatic male seniors, raising testosterone concentrations from moderately low to the normal midlife range has moderate benefits. Prior studies have yielded similar benefits in similar groups of men. What we are still missing is evidence of safety for this intervention. Specifically, we need to rule out the possibility that exogenous testosterone will increase deaths from atherosclerotic arterial disease, especially heart attacks, or neoplasms, especially prostate cancer.