On 2017 Jun 16, Jacob H. Hanna commented:

The last three papers from Smith group describing human transgene free "Reset cells", including this one, have failed to describe ability to generate teratomas. Mouse naive pluripotent cells have the intrinsic "self organizing capacity" to enter a formative/primed state after in vivo SC injection and make teratomas within 4-8 weeks. I find this stunning and wonder whether the human "reset" cells being induced do not qualify to be annotated as pluripotent cells at all. I hope the authors can clearly point out and directly address this critical caveat.

On 2017 Jun 16, Jacob H. Hanna commented:

The last three papers from Smith group describing human transgene free "Reset cells", including this one, have failed to describe ability to generate teratomas. Mouse naive pluripotent cells have the intrinsic "self organizing capacity" to enter a formative/primed state after in vivo SC injection and make teratomas within 4-8 weeks. I find this stunning and wonder whether the human "reset" cells being induced do not qualify to be annotated as pluripotent cells at all. I hope the authors can clearly point out and directly address this critical caveat.