On 2016 Aug 24, Jim Woodgett commented:

A relatively minor point, but the inhibitors used here, lithium and SB216763 (and also BIO, which is mentioned in the Discussion) are not selective for GSK-3beta as they are equipotent towards the GSK-3alpha isoform. This could be simply remedied by deleting the "beta" from each mention of GSK-3beta. Of note, there are currently no isoform-selective small molecule antagonists of GSK-3. Both isoforms are largely redundant (though there are some differences), similarly regulated and widely expressed.

On 2016 Aug 24, Jim Woodgett commented:

A relatively minor point, but the inhibitors used here, lithium and SB216763 (and also BIO, which is mentioned in the Discussion) are not selective for GSK-3beta as they are equipotent towards the GSK-3alpha isoform. This could be simply remedied by deleting the "beta" from each mention of GSK-3beta. Of note, there are currently no isoform-selective small molecule antagonists of GSK-3. Both isoforms are largely redundant (though there are some differences), similarly regulated and widely expressed.