On 2016 Apr 25, Dita Gratzinger commented:

Dr. Itkin and colleagues provide a tour de force overview of hematopoeitic stem and progenitor cell maintenance and trafficking within the context of distinctive capillary/arteriolar and sinusoidal vascular beds in the mouse. In parallel to their findings in mouse, we have previously described the analogous vascular beds in intact human marrow, particularly the nestin+ capillary/arteriolar bed, which is tightly wrapped in SMA/CD146+ pericytes/vascular smooth muscle which in turn is wrapped in CD271+ mesenchymal stromal cells (MSCs), as distinct from the nestin-negative sinusoidal endothelium in direct contact with MSCs; the MSCs are then in direct contact with CD34+ hematopoietic progenitor or stem cells Flores-Figueroa E, 2012. CD105 is a specific sinusoidal vascular marker and nestin as a specific capillary/arteriolar marker in intact human bone marrow, allowing for quantification of the distinct vascular beds in the setting of myelodysplastic syndromes Ewalt MD, 2016.

On 2016 Apr 25, Dita Gratzinger commented:

Dr. Itkin and colleagues provide a tour de force overview of hematopoeitic stem and progenitor cell maintenance and trafficking within the context of distinctive capillary/arteriolar and sinusoidal vascular beds in the mouse. In parallel to their findings in mouse, we have previously described the analogous vascular beds in intact human marrow, particularly the nestin+ capillary/arteriolar bed, which is tightly wrapped in SMA/CD146+ pericytes/vascular smooth muscle which in turn is wrapped in CD271+ mesenchymal stromal cells (MSCs), as distinct from the nestin-negative sinusoidal endothelium in direct contact with MSCs; the MSCs are then in direct contact with CD34+ hematopoietic progenitor or stem cells Flores-Figueroa E, 2012. CD105 is a specific sinusoidal vascular marker and nestin as a specific capillary/arteriolar marker in intact human bone marrow, allowing for quantification of the distinct vascular beds in the setting of myelodysplastic syndromes Ewalt MD, 2016.