On 2017 Feb 01, Martine Crasnier-Mednansky commented:

It is astounding that the authors totally ignore the specific effects of cAMP on the lag phase of the glucose-lactose diauxie. Not only does addition of cAMP eliminate the diauxic lag, it also clearly impairs growth on glucose (see figure 1 in Ullmann A, 1968). An increased level of cAMP triggers a 'leaky' expression of CRP-cAMP-dependent genes and operons (including the lactose operon) thereby affecting growth on glucose. Leaky expression of genes reduces fitness in glucose, with a trade-off for a shorter diauxic lag (or, as in figure 1 mentioned above, a complete elimination of the lag phase resulting in biphasic growth). In the Escherichi coli glucose-lactose diauxie, there is a correlation between the cAMP level and the cost-benefit trade-off.

On 2017 Feb 01, Martine Crasnier-Mednansky commented:

It is astounding that the authors totally ignore the specific effects of cAMP on the lag phase of the glucose-lactose diauxie. Not only does addition of cAMP eliminate the diauxic lag, it also clearly impairs growth on glucose (see figure 1 in Ullmann A, 1968). An increased level of cAMP triggers a 'leaky' expression of CRP-cAMP-dependent genes and operons (including the lactose operon) thereby affecting growth on glucose. Leaky expression of genes reduces fitness in glucose, with a trade-off for a shorter diauxic lag (or, as in figure 1 mentioned above, a complete elimination of the lag phase resulting in biphasic growth). In the Escherichi coli glucose-lactose diauxie, there is a correlation between the cAMP level and the cost-benefit trade-off.