On 2016 May 13, thomas samaras commented:

This study certainly refutes the earlier studies reporting that some overweight was healthy. The World Cancer Research Fund Report (2007)recommended a BMI as low as possible within the normal range of 18.4-24.9. Fontana and Hu (2014) recommended a BMI of 20-21. Also, Hosegood found the optimum BMI for women in S. Asia was about 18.5-19.5. In addition, there are many biological parameters that become worse with increasing BMI from the low end of the BMI range. A few are listed below. Most involve undesirable increases in levels of the following parameters: Homocysteine, C-Reactive Protein, Sex Hormone Binding Globulin (higher is better), left ventricular mass, blood pressure, adiponectin (higher is better), mTOR, total cholesterol, low-density lipoprotein, high-density lipoprotein (higher is better), IGF-1, insulin, glucose, ApoB, and ApoA-1 (higher is better).

All of these have been found to increase mortality due to one or more of these causes: CVD, cancer, type 2 diabetes and all-cause mortality. Therefore, it is hard to see how higher levels of BMI have health benefits with the exception of special cases, such as frail, elderly people who lack adequate nutrition, suffer from digestive problems or have a chronic illness.

On 2016 May 13, thomas samaras commented:

This study certainly refutes the earlier studies reporting that some overweight was healthy. The World Cancer Research Fund Report (2007)recommended a BMI as low as possible within the normal range of 18.4-24.9. Fontana and Hu (2014) recommended a BMI of 20-21. Also, Hosegood found the optimum BMI for women in S. Asia was about 18.5-19.5. In addition, there are many biological parameters that become worse with increasing BMI from the low end of the BMI range. A few are listed below. Most involve undesirable increases in levels of the following parameters: Homocysteine, C-Reactive Protein, Sex Hormone Binding Globulin (higher is better), left ventricular mass, blood pressure, adiponectin (higher is better), mTOR, total cholesterol, low-density lipoprotein, high-density lipoprotein (higher is better), IGF-1, insulin, glucose, ApoB, and ApoA-1 (higher is better).

All of these have been found to increase mortality due to one or more of these causes: CVD, cancer, type 2 diabetes and all-cause mortality. Therefore, it is hard to see how higher levels of BMI have health benefits with the exception of special cases, such as frail, elderly people who lack adequate nutrition, suffer from digestive problems or have a chronic illness.