On 2016 Jun 09, Ali Poormohammadi commented:

None

On 2017 Jan 09, Jennifer L Kuk commented:

I completely agree with your comment regarding the "steeper positive association between BMI and glucose tolerance" and will keep this in mind for future publications. We used the term glucose tolerance because the values are from an oral glucose tolerance test and thus the graph is showing the association between BMI and glucose tolerance. But because higher numbers indicate intolerance, I can see how this rapidly becomes confusing. Hopefully our conclusion "Therefore, consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance." made it clear.

On 2016 Dec 12, C. Alan Titchenal commented:

Thanks for your reply Jennifer and excuse my slow follow-up. My main point may have been missed. In the abstract, the statement that ". . . those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance" seems to be incorrect because your paper (Fig 1) shows a positive association between BMI and glucose INTOLERANCE based on 2-hour glucose levels. The way I read the abstract, it indicates that people with higher BMI values had better glucose tolerance - the opposite of what I think you intended to say based on your data and your reply to my previous comment.

On 2016 Jun 08, Jennifer L Kuk commented:

It is possible that individuals with impaired glucose tolerance could be opting for artificial sweeteners to decrease their carbohydrate intake. However, our results were the same with and without individuals with diabetes. Further, these observations were not seen with fasting glucose. As OGTTs are not commonly done in individuals without elevated fasting glucose, it is unlikely that these individuals would know to change their diet. Finally, given that there are studies that report a possible physiological rationale for our observation, we thought that our interpretation may be more likely.

Our conclusion that individuals who consume aspartame and have obesity, have worse glucose tolerance is entirely consistent with the interpretation that there is a steeper positive slope. From the graph, you will see that the greater slope between BMI and glucose intolerance in aspartame consumers means that there is a higher glucose intolerance for only individuals with a higher BMI.

On 2016 May 27, C. Alan Titchenal commented:

There appears to be a discrepancy in this abstract. It states that ". . . those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance" (i.e. as BMI increases, so does glucose tolerance) and then it concludes that aspartame consumption is associated with "obesity-related impairments in glucose tolerance." It also seems that their conclusion could suggest that overweight/obese people with impaired glucose tolerance are more likely to opt for artificial sweeteners in attempts to decrease their carbohydrate intake.

On 2016 May 27, C. Alan Titchenal commented:

There appears to be a discrepancy in this abstract. It states that ". . . those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance" (i.e. as BMI increases, so does glucose tolerance) and then it concludes that aspartame consumption is associated with "obesity-related impairments in glucose tolerance." It also seems that their conclusion could suggest that overweight/obese people with impaired glucose tolerance are more likely to opt for artificial sweeteners in attempts to decrease their carbohydrate intake.

On 2016 Jun 09, Ali Poormohammadi commented:

None