3 Matching Annotations
  1. Jul 2018
    1. On 2017 Apr 26, L. Norton commented:

      The conclusion is justified. Other studies have shown convincingly that anesthesia acutely raises glucose levels in BL/6J mice in the absence of a glucose load (PMID: 16332272). For some forms of anesthesia, the effect can last for at least 60 minutes. Of course this may differ somewhat between BL/6 strains, but I would expect to see similar results to be honest.


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    2. On 2017 Jan 31, Alexander Kraev commented:

      The conclusion of this study is not justified, as the authors used only one mouse strain. Also it would be useful to know the correct name for their strain, whether it was C57BL/6J or C57BL/6NCrl. C57BL/6J, which was likely used in this work, is known to have glucose intolerance in the absence of anesthesia due to deletion of the Nnt gene. Hence, the correct conclusion would be that C57BL/6J should not be used in metabolic studies.


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  2. Feb 2018
    1. On 2017 Jan 31, Alexander Kraev commented:

      The conclusion of this study is not justified, as the authors used only one mouse strain. Also it would be useful to know the correct name for their strain, whether it was C57BL/6J or C57BL/6NCrl. C57BL/6J, which was likely used in this work, is known to have glucose intolerance in the absence of anesthesia due to deletion of the Nnt gene. Hence, the correct conclusion would be that C57BL/6J should not be used in metabolic studies.


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