- Jul 2018
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europepmc.org europepmc.org
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On 2016 Dec 14, Martine Crasnier-Mednansky commented:
In Escherichia coli, CRP stands for Cyclic AMP Receptor Protein, not Catabolite Repressor Protein. CRP is also known—and rightly so—as CAP, the Catabolite gene Activator Protein. Repression by CRP-cAMP, was recognized as early as 1972 (Prusiner S, 1972) and later on emphasized. See, for an elaborate discussion, Kolb A, 1993. In this context, the designation 'Cyclic AMP Receptor Protein' is fully appropriate and has been used preferentially over the more specific designation 'Catabolite gene Activator Protein'.
Glucose is not "a known inhibitor of CyaA activity". In fact, transport of glucose prevents activation of CyaA by a phosphorylated component of the phosphotransferase system (PTS). Such regulation is relevant to the present work because, upon glucose exhaustion (or some other PTS-transported carbon sources), there is a sharp increase in exogenous cAMP, which may act as a trigger at the onset of the infection.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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On 2016 Dec 14, Martine Crasnier-Mednansky commented:
In Escherichia coli, CRP stands for Cyclic AMP Receptor Protein, not Catabolite Repressor Protein. CRP is also known—and rightly so—as CAP, the Catabolite gene Activator Protein. Repression by CRP-cAMP, was recognized as early as 1972 (Prusiner S, 1972) and later on emphasized. See, for an elaborate discussion, Kolb A, 1993. In this context, the designation 'Cyclic AMP Receptor Protein' is fully appropriate and has been used preferentially over the more specific designation 'Catabolite gene Activator Protein'.
Glucose is not "a known inhibitor of CyaA activity". In fact, transport of glucose prevents activation of CyaA by a phosphorylated component of the phosphotransferase system (PTS). Such regulation is relevant to the present work because, upon glucose exhaustion (or some other PTS-transported carbon sources), there is a sharp increase in exogenous cAMP, which may act as a trigger at the onset of the infection.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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