On 2016 Dec 29, Steve Alexander commented:

Oleamide (https://pubchem.ncbi.nlm.nih.gov/compound/5283387, called 9-octadecenamide here) has previously been investigated as a ligand at all three PPARs in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414753/ Interesting to see the presence of other primary amides in the brain, notably palmitamide (https://pubchem.ncbi.nlm.nih.gov/compound/69421, called hexadecanamide here). An essential next couple of steps will be to identify the synthetic and degradative pathways associated with these ligands, and how/whether these compounds change with patho/physiological influences.

On 2016 Dec 29, Steve Alexander commented:

Oleamide (https://pubchem.ncbi.nlm.nih.gov/compound/5283387, called 9-octadecenamide here) has previously been investigated as a ligand at all three PPARs in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414753/ Interesting to see the presence of other primary amides in the brain, notably palmitamide (https://pubchem.ncbi.nlm.nih.gov/compound/69421, called hexadecanamide here). An essential next couple of steps will be to identify the synthetic and degradative pathways associated with these ligands, and how/whether these compounds change with patho/physiological influences.