On 2017 Mar 19, Harri Hemila commented:

Shortcomings in the meta-analysis on vitamin C and atrial fibrillation

In their meta-analysis on vitamin C and postoperative atrial fibrillation (POAF), Baker WL, 2016 stated that they restricted to randomized trials; however, they included the Carnes CA, 2001 study which was not randomized. Furthermore, their meta-analysis did not include data for three US trials, two of which were substantially larger than the included POAF trials, see Hemilä H, 2017.

The conclusion by Baker WL, 2016 that vitamin C does have effects on POAF is reasonable, yet their analysis did not reveal the significant heterogeneity in the effects. Although 5 trials studies in the USA found no benefit, several studies in less wealthy countries have found significant benefit of vitamin C against POAF indicating that further research should be carried in less wealthy countries, see Hemilä H, 2017.

On 2017 Mar 19, Harri Hemila commented:

Shortcomings in the meta-analysis on vitamin C and atrial fibrillation

In their meta-analysis on vitamin C and postoperative atrial fibrillation (POAF), Baker WL, 2016 stated that they restricted to randomized trials; however, they included the Carnes CA, 2001 study which was not randomized. Furthermore, their meta-analysis did not include data for three US trials, two of which were substantially larger than the included POAF trials, see Hemilä H, 2017.

The conclusion by Baker WL, 2016 that vitamin C does have effects on POAF is reasonable, yet their analysis did not reveal the significant heterogeneity in the effects. Although 5 trials studies in the USA found no benefit, several studies in less wealthy countries have found significant benefit of vitamin C against POAF indicating that further research should be carried in less wealthy countries, see Hemilä H, 2017.