On 2016 Nov 20, Alessandro Rasman commented:

Bernhard HJ. Juurlink MD, Dario Alpini MD, Giampiero Avruscio MD, Miro Denislic MD, Attilio Guazzoni MD, Laura Mendozzi MD, Raffaello Pagani MD, Adnan Siddiqui MD, PierluigI Stimamiglio MD, Pierfrancesco Veroux MD snd Pietro Maria Bavera MD

We read with interest the consensus statement titled "The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative" (1). We wonder why the authors haven't cited in the notes any paper of Dr. Paolo Zamboni from University of Ferrara, Italy. Particulary, his oldest paper titled "The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis" published in November 2006 (2). In that paper he readily showed the histology of the CVS, and explicitly reported the possibility to image it by the means of MR, as well.

References: 1) Sati, Pascal, et al. "The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative." Nature Reviews Neurology (2016). 2) Zamboni, Paolo. "The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis." Journal of the Royal Society of Medicine 99.11 (2006): 589-593.

On 2016 Nov 20, Alessandro Rasman commented:

Bernhard HJ. Juurlink MD, Dario Alpini MD, Giampiero Avruscio MD, Miro Denislic MD, Attilio Guazzoni MD, Laura Mendozzi MD, Raffaello Pagani MD, Adnan Siddiqui MD, PierluigI Stimamiglio MD, Pierfrancesco Veroux MD snd Pietro Maria Bavera MD

We read with interest the consensus statement titled "The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative" (1). We wonder why the authors haven't cited in the notes any paper of Dr. Paolo Zamboni from University of Ferrara, Italy. Particulary, his oldest paper titled "The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis" published in November 2006 (2). In that paper he readily showed the histology of the CVS, and explicitly reported the possibility to image it by the means of MR, as well.

References: 1) Sati, Pascal, et al. "The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative." Nature Reviews Neurology (2016). 2) Zamboni, Paolo. "The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis." Journal of the Royal Society of Medicine 99.11 (2006): 589-593.