On 2017 Jul 31, Robin P Clarke commented:

Nutrient deficiencies being factors in autism causation was predicted by the antiinnatia theory of autism (Clarke, 1993; Clarke, 2016), which stated that autism is caused by a high level of "antiinnatia factors" (factors tending to cause a sort of "general" reduction of gene-expression).

It was stated therein that "Gene-expression depends on processes that have many possibilities for malfunction, with many common factors underlying (for instance) all transcription from DNA, all being dependent on, for example, supply of nutrients....".<br> And that thus the autism-causing antiinnatia would tend to result from nutrient deficiencies (though of course nutrient deficits would also produce their own specific symptoms such as bone problems in respect of vit D).

The extent to which supplementation later in life can reverse the effects of deficiency in earlier developmental periods would depend on to what extent irreversible effects have been caused, such as perhaps neurons not migrating in neurotypical ways, or learning processes delayed too long.

Future studies should perhaps look for the possibility that the supplementation has more effect on younger children and less (or no) effect on older ones. It would further be expected that the improvements would be relatively permanent rather than ceasing on discontinuation of the supplementation.

Clarke RP (1993) A theory of general impairment of gene-expression manifesting as autism. Personality and Individual Differences 14,465-482.

Clarke RP (2016) (Updated presentation of preceding) - (PDF-file:) A theory of evolution-biased reduction of gene-expression manifesting as autism.

On 2017 Jul 31, Robin P Clarke commented:

Nutrient deficiencies being factors in autism causation was predicted by the antiinnatia theory of autism (Clarke, 1993; Clarke, 2016), which stated that autism is caused by a high level of "antiinnatia factors" (factors tending to cause a sort of "general" reduction of gene-expression).

It was stated therein that "Gene-expression depends on processes that have many possibilities for malfunction, with many common factors underlying (for instance) all transcription from DNA, all being dependent on, for example, supply of nutrients....".<br> And that thus the autism-causing antiinnatia would tend to result from nutrient deficiencies (though of course nutrient deficits would also produce their own specific symptoms such as bone problems in respect of vit D).

The extent to which supplementation later in life can reverse the effects of deficiency in earlier developmental periods would depend on to what extent irreversible effects have been caused, such as perhaps neurons not migrating in neurotypical ways, or learning processes delayed too long.

Future studies should perhaps look for the possibility that the supplementation has more effect on younger children and less (or no) effect on older ones. It would further be expected that the improvements would be relatively permanent rather than ceasing on discontinuation of the supplementation.

Clarke RP (1993) A theory of general impairment of gene-expression manifesting as autism. Personality and Individual Differences 14,465-482.

Clarke RP (2016) (Updated presentation of preceding) - (PDF-file:) A theory of evolution-biased reduction of gene-expression manifesting as autism.