On 2017 Sep 08, Koene Van Dijk commented:

CAUTION: Something went terribly wrong during the peer-review process of this manuscript

The study by Molfino et al., (2017, 10.1002/jcsm.12156) included extremely small samples (n=9 and n=4 for patient groups and n=2 for the control group).

According to the text of the manuscript, BOLD fMRI data that was collected did not undergo any pre-processing to remove noise but raw values from a hand-drawn region of interest were exported from the Siemens scanner console and imported into Microsoft Excel.

No statistical analysis was applied to measure contrast between different conditions, but raw BOLD values before (during time frames 0-50), during (time frames 51-261), and after (single time frame 262) nutritional ingestion values were calculated/extracted.

I recommend the authors and readers who want to learn more about BOLD fMRI data collection and analyses to read "Handbook of Functional MRI Data Analysis" by Poldrack, Mumford, and Nichols.

DISCLAIMER: I am an employee of Pfizer. The statements or opinions expressed on this site are my own and do not necessarily represent those of Pfizer.

On 2017 Sep 08, Koene Van Dijk commented:

CAUTION: Something went terribly wrong during the peer-review process of this manuscript

The study by Molfino et al., (2017, 10.1002/jcsm.12156) included extremely small samples (n=9 and n=4 for patient groups and n=2 for the control group).

According to the text of the manuscript, BOLD fMRI data that was collected did not undergo any pre-processing to remove noise but raw values from a hand-drawn region of interest were exported from the Siemens scanner console and imported into Microsoft Excel.

No statistical analysis was applied to measure contrast between different conditions, but raw BOLD values before (during time frames 0-50), during (time frames 51-261), and after (single time frame 262) nutritional ingestion values were calculated/extracted.

I recommend the authors and readers who want to learn more about BOLD fMRI data collection and analyses to read "Handbook of Functional MRI Data Analysis" by Poldrack, Mumford, and Nichols.

DISCLAIMER: I am an employee of Pfizer. The statements or opinions expressed on this site are my own and do not necessarily represent those of Pfizer.