On 2017 Jan 15, Ashraf Nabhan commented:

I thank the authors for this elegant work. The Results are reassuring regarding the risk of congenital malformations after ACE inhibitor exposure during the first trimester. The authors made a wise note to caregivers that women on ACE-I during reproductive years should have a transition off of these medications early in pregnancy to avoid the known adverse fetal effects associated with late pregnancy exposure. This wise note should have appeared in the abstract, since we know that most readers only read the abstract as many do not have access to the full text and some only focus on the authors' conclusion.

On 2017 Jan 15, Ashraf Nabhan commented:

I thank the authors for this elegant work. The Results are reassuring regarding the risk of congenital malformations after ACE inhibitor exposure during the first trimester. The authors made a wise note to caregivers that women on ACE-I during reproductive years should have a transition off of these medications early in pregnancy to avoid the known adverse fetal effects associated with late pregnancy exposure. This wise note should have appeared in the abstract, since we know that most readers only read the abstract as many do not have access to the full text and some only focus on the authors' conclusion.