On 2017 May 22, NephJC - Nephrology Journal Club commented:

This trial on the comparison of peritoneal dialysis versus furosemide in pediatric post-operative acute kidney injury, was discussed on May 23rd and 24th 2017 on #NephJC, the open online nephrology journal club. Introductory comments written by Michelle Rheault are available at the NephJC website here The discussion was quite detailed, with over 90 participants, including pediatric and adult nephrologists and fellows, and joined by author Dave Kwiatkowski. The highlights of the tweetchat were:

• The authors should be commended for designing and conducting this important trial, with funding received from the American Heart Association–Great Rivers Affiliate and the Cincinnati Children’s Hospital Medical Center

• Overall, it was thought to be a well-designed and well-conducted trial, with possible weaknesses being the use of bolus (rather than continuous infusion) of furosemide in the control arm, and the importance of negative fluid balance at day 1 as an important outcome being possible weaknesses

• The results were thought to be quite valid and important, and given the not uncommon risk of acute kidney injury and fluid overload in this setting, that preemptive peritoneal dialysis catheters should be considered more often in children at high risk Transcripts of the tweetchats, and curated versions as storify are available from the NephJC website. Interested individuals can track and join in the conversation by following @NephJC or #NephJC on twitter, liking @NephJC on facebook, signing up for the mailing list, or just visit the webpage at NephJC.com.

On 2017 May 22, NephJC - Nephrology Journal Club commented:

This trial on the comparison of peritoneal dialysis versus furosemide in pediatric post-operative acute kidney injury, was discussed on May 23rd and 24th 2017 on #NephJC, the open online nephrology journal club. Introductory comments written by Michelle Rheault are available at the NephJC website here The discussion was quite detailed, with over 90 participants, including pediatric and adult nephrologists and fellows, and joined by author Dave Kwiatkowski. The highlights of the tweetchat were:

• The authors should be commended for designing and conducting this important trial, with funding received from the American Heart Association–Great Rivers Affiliate and the Cincinnati Children’s Hospital Medical Center

• Overall, it was thought to be a well-designed and well-conducted trial, with possible weaknesses being the use of bolus (rather than continuous infusion) of furosemide in the control arm, and the importance of negative fluid balance at day 1 as an important outcome being possible weaknesses

• The results were thought to be quite valid and important, and given the not uncommon risk of acute kidney injury and fluid overload in this setting, that preemptive peritoneal dialysis catheters should be considered more often in children at high risk Transcripts of the tweetchats, and curated versions as storify are available from the NephJC website. Interested individuals can track and join in the conversation by following @NephJC or #NephJC on twitter, liking @NephJC on facebook, signing up for the mailing list, or just visit the webpage at NephJC.com.