- Jul 2018
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europepmc.org europepmc.org
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On 2017 Oct 31, Lise Bankir commented:
About osmoles and osmolytes
It is important to use the right words to ensure an unambiguous understanding of the diverse aspects of scientific studies. Thus, I would like to draw attention to the difference between "osmolytes" and "osmoles".
The word "osmolyte" is misused in this paper and should be replaced throughout by "osmole".
Osmoles (e.g. sodium, potassium, chloride, urea, glucose) are substances that increase the osmolarity of the fluid in which they are dissolved.<br> Osmolytes (e.g. betaine, sorbitol, myoinositol, glycine, taurine, methyamines) are substances that accumulate inside cells to protect them from a high ambient osmolarity.
See definition of osmolytes in the two encyclopedia below.
http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/osmolyte
https://en.wiktionary.org/wiki/osmolyte
See also reviews about osmolytes (two examples given below).
J Exp Biol. 2005 Aug;208(Pt 15):2819-30. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Yancey PH
Curr Opin Nephrol Hypertens. 1997 Sep;6(5):430-3. Renal osmoregulatory transport of compatible organic osmolytes. Burg MB
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY. -
On 2017 Aug 28, NephJC - Nephrology Journal Club commented:
The controversial and thought-provoking paper “Increased salt consumption induces body water conservation and decreases fluid intake.” was discussed on June 6th and 7th 2017 on #NephJC, the open online nephrology journal club.
Introductory comments written by Joel Topf are available at the NephJC website here
181 people participated in the discussion with nearly 1000 tweets. We were delighted that Paul Welling, an expert in renal physiology also joined in the chat.
The highlights of the tweetchat were:
Nephrologists were surprised that the ‘basic tenet’ of Nephrology that is steady state sodium balance is now in dispute.
The methodology of this study was very impressive with the simulated Mars missions Mars105 and Mars 520 providing a unique opportunity to do prolonged metabolic balance studies, albeit in only 10 subjects.
It was unclear if the salt content was blinded or not and this may limit result interpretation.
It’s interesting that cortisol may have a more important role in sodium/water balance than previously thought via its stimulation of protein catabolism to generate more urea for urine concentration, however its overall significance is still thought to be considerably less than that of ADH/aldosterone.
Transcripts of the tweetchats, and curated versions as storify are available from the NephJC website.
Interested individuals can track and join in the conversation by following @NephJC or #NephJC on twitter, liking @NephJC on facebook, signing up for the mailing list, or just visit the webpage at NephJC.com.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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On 2017 Aug 28, NephJC - Nephrology Journal Club commented:
The controversial and thought-provoking paper “Increased salt consumption induces body water conservation and decreases fluid intake.” was discussed on June 6th and 7th 2017 on #NephJC, the open online nephrology journal club.
Introductory comments written by Joel Topf are available at the NephJC website here
181 people participated in the discussion with nearly 1000 tweets. We were delighted that Paul Welling, an expert in renal physiology also joined in the chat.
The highlights of the tweetchat were:
Nephrologists were surprised that the ‘basic tenet’ of Nephrology that is steady state sodium balance is now in dispute.
The methodology of this study was very impressive with the simulated Mars missions Mars105 and Mars 520 providing a unique opportunity to do prolonged metabolic balance studies, albeit in only 10 subjects.
It was unclear if the salt content was blinded or not and this may limit result interpretation.
It’s interesting that cortisol may have a more important role in sodium/water balance than previously thought via its stimulation of protein catabolism to generate more urea for urine concentration, however its overall significance is still thought to be considerably less than that of ADH/aldosterone.
Transcripts of the tweetchats, and curated versions as storify are available from the NephJC website.
Interested individuals can track and join in the conversation by following @NephJC or #NephJC on twitter, liking @NephJC on facebook, signing up for the mailing list, or just visit the webpage at NephJC.com.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY. -
On 2017 Oct 31, Lise Bankir commented:
About osmoles and osmolytes
It is important to use the right words to ensure an unambiguous understanding of the diverse aspects of scientific studies. Thus, I would like to draw attention to the difference between "osmolytes" and "osmoles".
The word "osmolyte" is misused in this paper and should be replaced throughout by "osmole".
Osmoles (e.g. sodium, potassium, chloride, urea, glucose) are substances that increase the osmolarity of the fluid in which they are dissolved.<br> Osmolytes (e.g. betaine, sorbitol, myoinositol, glycine, taurine, methyamines) are substances that accumulate inside cells to protect them from a high ambient osmolarity.
See definition of osmolytes in the two encyclopedia below.
http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/osmolyte
https://en.wiktionary.org/wiki/osmolyte
See also reviews about osmolytes (two examples given below).
J Exp Biol. 2005 Aug;208(Pt 15):2819-30. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Yancey PH
Curr Opin Nephrol Hypertens. 1997 Sep;6(5):430-3. Renal osmoregulatory transport of compatible organic osmolytes. Burg MB
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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