On 2017 Apr 22, Alessandro Rasman commented:

Aldo Bruno MD, Pietro M. Bavera MD, Aldo d'Alessandro MD, Giampiero Avruscio MD, Pietro Cecconi MD, Massimiliano Farina MD, Raffaello Pagani MD, Pierluigi Stimamiglio MD, Arnaldo Toffon MD and Alessandro Rasman

We read with interest this study by Zakaria et al. titled "Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency".(1) Unfortunately the authors ligated the external jugular veins of the rats and not the internal jugular veins. Dr, Zamboni's theory on chronic cerebrospinal venous insufficiency is based on the internal jugular veins and not on external jugular veins.(2) Maybe the authors can read the two papers from Dr. Mancini et al. (3) and (4). So, in our opinion the title of this study is absolutely not correct.

References: 1. Zakaria, Maha MA, et al. "Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency." Folia Neuropathologica 55.1 (2017): 49-59. 2. Zamboni, Paolo, et al. "Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis." Journal of Neurology, Neurosurgery & Psychiatry 80.4 (2009): 392-399. 3. Mancini, Marcello, et al. "Head and neck veins of the mouse. A magnetic resonance, micro computed tomography and high frequency color Doppler ultrasound study." PloS one 10.6 (2015): e0129912. 4. Auletta, Luigi, et al. "Feasibility and safety of two surgical techniques for the development of an animal model of jugular vein occlusion." Experimental Biology and Medicine 242.1 (2017): 22-28.

On 2017 Apr 22, Alessandro Rasman commented:

Aldo Bruno MD, Pietro M. Bavera MD, Aldo d'Alessandro MD, Giampiero Avruscio MD, Pietro Cecconi MD, Massimiliano Farina MD, Raffaello Pagani MD, Pierluigi Stimamiglio MD, Arnaldo Toffon MD and Alessandro Rasman

We read with interest this study by Zakaria et al. titled "Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency".(1) Unfortunately the authors ligated the external jugular veins of the rats and not the internal jugular veins. Dr, Zamboni's theory on chronic cerebrospinal venous insufficiency is based on the internal jugular veins and not on external jugular veins.(2) Maybe the authors can read the two papers from Dr. Mancini et al. (3) and (4). So, in our opinion the title of this study is absolutely not correct.

References: 1. Zakaria, Maha MA, et al. "Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency." Folia Neuropathologica 55.1 (2017): 49-59. 2. Zamboni, Paolo, et al. "Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis." Journal of Neurology, Neurosurgery & Psychiatry 80.4 (2009): 392-399. 3. Mancini, Marcello, et al. "Head and neck veins of the mouse. A magnetic resonance, micro computed tomography and high frequency color Doppler ultrasound study." PloS one 10.6 (2015): e0129912. 4. Auletta, Luigi, et al. "Feasibility and safety of two surgical techniques for the development of an animal model of jugular vein occlusion." Experimental Biology and Medicine 242.1 (2017): 22-28.