2 Matching Annotations
- Jul 2018
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europepmc.org europepmc.org
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On 2017 Sep 12, Ryan Jajosky commented:
For trainees, knowing that Bernard-Soulier syndrome protects against TTP can help you remember the pathogenesis of these conditions.
Ultra-large vWF multimers bind to GP Ib-IX-V on platelets and cause TTP, but patients with Bernard-Soulier syndrome have deficient / defective GP Ib-IX-V, so the disease process is blocked.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
-
europepmc.org europepmc.org
-
On 2017 Sep 12, Ryan Jajosky commented:
For trainees, knowing that Bernard-Soulier syndrome protects against TTP can help you remember the pathogenesis of these conditions.
Ultra-large vWF multimers bind to GP Ib-IX-V on platelets and cause TTP, but patients with Bernard-Soulier syndrome have deficient / defective GP Ib-IX-V, so the disease process is blocked.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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