On 2017 Aug 16, Deepa Bhartiya commented:

Authors report primitive, rare Oct-4 positive neural stem cells (pNSCs) in adult mouse brain that form spheres in vitro and also participate in endogenous regeneration. The pNSCs are activated in response to a stress produced by treatment with an antimitotic agent. Authors claim credit for pNSC to be the only adult stem cell to express OCT-4. But this is not true.

We have similarly reported that rare, small sized, pluripotent OCT-4 positive stem cells exist in adult testis, survive chemotherapy (https://www.ncbi.nlm.nih.gov/pubmed/27663915) and rather get activated in response to stress produced by busulphan treatment. Similarly OCT-4 expressing stem cells in adult bone marrow survive and are activated after radiotherapy (https://www.ncbi.nlm.nih.gov/pubmed/21034791) and chemotherapy (https://www.ncbi.nlm.nih.gov/pubmed/27095238). OCT-4 positive stem cells exist in all adult organs and are not limited to only the adult brain as claimed by the authors of this study. This needs to be corrected and a bigger picture of existence of pluripotent OCT-4 positive stem cells in various adult tissues needs to emerge.

On 2017 Aug 16, Deepa Bhartiya commented:

Authors report primitive, rare Oct-4 positive neural stem cells (pNSCs) in adult mouse brain that form spheres in vitro and also participate in endogenous regeneration. The pNSCs are activated in response to a stress produced by treatment with an antimitotic agent. Authors claim credit for pNSC to be the only adult stem cell to express OCT-4. But this is not true.

We have similarly reported that rare, small sized, pluripotent OCT-4 positive stem cells exist in adult testis, survive chemotherapy (https://www.ncbi.nlm.nih.gov/pubmed/27663915) and rather get activated in response to stress produced by busulphan treatment. Similarly OCT-4 expressing stem cells in adult bone marrow survive and are activated after radiotherapy (https://www.ncbi.nlm.nih.gov/pubmed/21034791) and chemotherapy (https://www.ncbi.nlm.nih.gov/pubmed/27095238). OCT-4 positive stem cells exist in all adult organs and are not limited to only the adult brain as claimed by the authors of this study. This needs to be corrected and a bigger picture of existence of pluripotent OCT-4 positive stem cells in various adult tissues needs to emerge.