- Jul 2018
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europepmc.org europepmc.org
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On 2018 Jan 30, Jim Woodgett commented:
Characterization of a novel GSK3-like kinase (GlkA) in slime mold that is related to GskA and (similarly to GskA) acts downstream of cAMP in regulating chemotaxis. Rescue data show increased expression of GskA in glkA nulls is unable to complement (unlike re-expression of GlkA) and vice versa. Paper includes comparisons with mammalian isoforms (GSK-3 alpha and beta) and finds GskA target, Daydreamer, is also targeted by GlkA. A huge amount of data in this study including iTRAQ comparative proteomics. Would be good to know if lithium inhibits glkA.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2018 Jan 30, Jim Woodgett commented:
Characterization of a novel GSK3-like kinase (GlkA) in slime mold that is related to GskA and (similarly to GskA) acts downstream of cAMP in regulating chemotaxis. Rescue data show increased expression of GskA in glkA nulls is unable to complement (unlike re-expression of GlkA) and vice versa. Paper includes comparisons with mammalian isoforms (GSK-3 alpha and beta) and finds GskA target, Daydreamer, is also targeted by GlkA. A huge amount of data in this study including iTRAQ comparative proteomics. Would be good to know if lithium inhibits glkA.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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