135 Matching Annotations
  1. Last 7 days
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    RAD51 protects abasic sites to prevent replication fork breakage
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    1. scibot 23 Aug 2024
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      DOI: 10.1016/j.molcel.2024.07.004

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    sciencedirect.com/science/article/pii/S109727652400580X
  3. Aug 2024
  4. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
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    1. scibot 13 Aug 2024
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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  5. Jul 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterising replisome disassembly in human cells
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    1. scibot 19 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269944/
  7. Jun 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
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    sciencedirect.com/science/article/pii/S1534580724003277
  9. May 2024
  10. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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    1. scibot 16 May 2024
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      DOI: 10.1038/nature12362

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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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    sciencedirect.com/science/article/pii/S2211124724005333
  12. Apr 2024
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    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-1459

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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
    2
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114116

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      DOI: 10.1016/j.celrep.2024.114116

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    sciencedirect.com/science/article/pii/S2211124724004443
  15. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
    1. scibot 18 Apr 2024
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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
    1
    1. scibot 10 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114064

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      RRID:AB_10015219

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    sciencedirect.com/science/article/pii/S2211124724003929
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    1. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724003528
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.cell.2024.03.002

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    sciencedirect.com/science/article/pii/S0092867424002502
  20. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
    1
    1. scibot 29 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001758
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.celrep.2023.113637

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883656/
  23. Feb 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
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    1. scibot 16 Feb 2024
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      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
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    Specialized replication mechanisms maintain genome stability at human centromeres
    2
    1. scibot 15 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000546
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1016/j.dnarep.2024.103646

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    sciencedirect.com/science/article/pii/S1568786424000223
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    1. scibot 13 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001062
  28. www.nature.com www.nature.com
    A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
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      DOI: 10.1038/s41698-024-00500-5

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    nature.com/articles/s41698-024-00500-5
  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
    1
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      DOI: 10.1016/j.isci.2023.108655

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    ncbi.nlm.nih.gov/pmc/articles/PMC10783591/
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    Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis
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    1. scibot 11 Jan 2024
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    sciencedirect.com/science/article/pii/S0889159124000059
  32. www.sciencedirect.com www.sciencedirect.com
    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
    1
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      DOI: 10.1016/j.devcel.2023.12.002

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    sciencedirect.com/science/article/pii/S1534580723006524
  33. Dec 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe
    1
    1. scibot 23 Dec 2023
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      DOI: 10.1158/2767-9764.CRC-23-0306

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    ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line
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    1. scibot 23 Dec 2023
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      DOI: 10.1016/j.isci.2023.108678

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    ncbi.nlm.nih.gov/pmc/articles/PMC10776957/
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113523

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    sciencedirect.com/science/article/pii/S2211124723015358
  37. Nov 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
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    sciencedirect.com/science/article/pii/S2211124723013190
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Social withdrawal and anxiety-like behavior have an impact on zebrafish adult neurogenesis
    1
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      DOI: 10.3389/fnbeh.2023.1244075

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    ncbi.nlm.nih.gov/pmc/articles/PMC10614005/
  40. Oct 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
    1
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    sciencedirect.com/science/article/pii/S1550413123003716
  42. Sep 2023
  43. 52.53.155.43 52.53.155.43
    can-22-3646-html.html
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    52.53.155.43/7c5c0394bd7eaeefd5e70a237f23894cb3f7190b/can-22-3646-html.html
  44. Aug 2023
  45. www.nature.com www.nature.com
    Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
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      DOI: 10.1038/s41467-023-39873-9

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    nature.com/articles/s41467-023-39873-9
  46. Jul 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    sciencedirect.com/science/article/pii/S1097276523004720
  48. Jun 2023
  49. www.sciencedirect.com www.sciencedirect.com
    FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
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      DOI: 10.1016/j.celrep.2023.112668

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    sciencedirect.com/science/article/pii/S2211124723006794
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    1. scibot 09 Jun 2023
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      DOI: 10.1016/j.isci.2023.106951

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    sciencedirect.com/science/article/pii/S2589004223010283
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    Centromere/kinetochore is assembled through CENP-C oligomerization
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    sciencedirect.com/science/article/pii/S1097276523003799
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    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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    1. scibot 09 Jun 2023
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      DOI: 10.1016/j.molcel.2023.05.015

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    sciencedirect.com/science/article/pii/S1097276523003714
  53. May 2023
  54. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Developmental switch in the function of inhibitory commissural V0d interneurons in zebrafish
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  56. Apr 2023
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    Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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    Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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  60. Mar 2023
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
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  63. Feb 2023
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    A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs
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  66. Jan 2023
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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  70. Dec 2022
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    Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
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    POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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  73. Nov 2022
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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  77. Oct 2022
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    DNA-PKcs promotes fork reversal and chemoresistance
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells
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  86. Jul 2022
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    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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  92. May 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
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    Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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  108. Aug 2021
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    RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia
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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    Zic4-Lineage Cells Increase Their Contribution to Visual Thalamic Nuclei during Murine Embryogenesis If They Are Homozygous or Heterozygous for Loss of Pax6 Function
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  116. Jul 2021
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    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
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    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
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    EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
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    p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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  128. Mar 2021
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  132. Feb 2021
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    The integrated stress response induces R-loops and hinders replication fork progression
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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  136. Jan 2021
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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  139. Dec 2020
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    TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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  143. Nov 2020
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    Essentiality of CENP-A Depends on Its Binding Mode to HJURP
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  145. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance
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  146. Oct 2020
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  148. Sep 2020
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    HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation
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    BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
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    EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
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    Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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  154. Jan 2020
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    Na + /H + exchanger isoform 1 activity in AQP2-expressing cells can be either proliferative or anti-proliferative depending on extracellular pH
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    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development
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    GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis
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  161. Nov 2018
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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers
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    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
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    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance
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    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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    Eye Absence Does Not Regulate Planarian Stem Cells during Eye Regeneration
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    Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
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