160 Matching Annotations
  1. Oct 2025
  2. www.science.org www.science.org
    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
  3. www.sciencedirect.com www.sciencedirect.com
    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
  4. Sep 2025
  5. www.sciencedirect.com www.sciencedirect.com
    RAD51 is chromatin enriched and targetable in BRCA1-deficient cells
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    sciencedirect.com/science/article/pii/S1097276525007026
  6. Aug 2025
  7. www.sciencedirect.com www.sciencedirect.com
    PARP inhibitors potentiate proton therapy end-of-range effects by accelerating replication forks and promoting transcription conflict
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    sciencedirect.com/science/article/pii/S0360301625061978
  8. 52.53.155.43 52.53.155.43
    2025.08.06.668996v1.full-html.html
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    52.53.155.43/9762f0542a12c1b879bb3817e6abf20525e5b06e/2025.08.06.668996v1.full-html.html
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331980/
  10. Jul 2025
  11. www.nature.com www.nature.com
    Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases
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    nature.com/articles/s41419-025-07812-9
  12. Jun 2025
  13. www.sciencedirect.com www.sciencedirect.com
    The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
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    sciencedirect.com/science/article/pii/S1097276525005027
  14. Apr 2025
  15. www.sciencedirect.com www.sciencedirect.com
    ASCL1 protein domains with distinct functions in neuronal differentiation and subtype specification
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    sciencedirect.com/science/article/pii/S0012160625000880
  16. www.sciencedirect.com www.sciencedirect.com
    Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis
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    sciencedirect.com/science/article/pii/S104474312500017X
  17. Dec 2024
  18. www.cell.com www.cell.com
    Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries
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    cell.com/cell-reports/fulltext/S2211-1247(24)01444-X
  19. www.sciencedirect.com www.sciencedirect.com
    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    sciencedirect.com/science/article/pii/S1097276524009894
  20. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
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    Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells
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    sciencedirect.com/science/article/pii/S153458072400697X
  22. Oct 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts
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    sciencedirect.com/science/article/pii/S1097276524007767
  24. Sep 2024
  25. www.jneurosci.org www.jneurosci.org
    Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia
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    jneurosci.org/content/39/29/5794
  26. Aug 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
  29. www.sciencedirect.com www.sciencedirect.com
    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
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    sciencedirect.com/science/article/pii/S2211124724009239
  30. Jul 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation
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    sciencedirect.com/science/article/pii/S0021925824019938
  32. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    sciencedirect.com/science/article/pii/S2211124724007939
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11219039/
  34. May 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11091264/
  36. 52.53.155.43 52.53.155.43
    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
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    52.53.155.43/d52a41e1a3d17093378781ca7887483638d670e8/2024.02.05.578390.full-html.html
  37. Apr 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S109727652400282X
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
  40. Mar 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  42. Feb 2024
  43. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  44. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA combing versus DNA spreading and the separation of sister chromatids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
  46. Jan 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  48. www.sciencedirect.com www.sciencedirect.com
    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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    sciencedirect.com/science/article/pii/S1097276523010717
  49. Dec 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    sciencedirect.com/science/article/pii/S009286742301276X
  51. www.sciencedirect.com www.sciencedirect.com
    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    sciencedirect.com/science/article/pii/S258900422302641X
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC10712957/
  53. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
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    52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
  54. Nov 2023
  55. link.springer.com link.springer.com
    Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli
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    link.springer.com/article/10.1007/s12035-023-03746-5
  56. Oct 2023
  57. www.sciencedirect.com www.sciencedirect.com
    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    sciencedirect.com/science/article/pii/S2589004223021806
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  59. Aug 2023
  60. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    science.org/doi/10.1126/science.adi3448
  61. www.biorxiv.org www.biorxiv.org
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
    1
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    biorxiv.org/content/10.1101/2023.08.21.554173v1
  62. www.sciencedirect.com www.sciencedirect.com
    Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1
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    sciencedirect.com/science/article/abs/pii/S1097276523005154
  63. Jun 2023
  64. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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    sciencedirect.com/science/article/pii/S1097276523003829
  65. May 2023
  66. www.science.org www.science.org
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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    science.org/doi/10.1126/sciadv.add8023
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10171824/
  68. www.biorxiv.org www.biorxiv.org
    DNA Combing versus DNA Spreading and the Separation of Sister Chromatids
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    biorxiv.org/content/10.1101/2023.05.02.539129v1
  69. www.sciencedirect.com www.sciencedirect.com
    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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    sciencedirect.com/science/article/pii/S0092867422007802
  70. Apr 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
  72. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    science.org/doi/10.1126/sciadv.ade7997
  73. Jan 2023
  74. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    sciencedirect.com/science/article/pii/S1097276522012175
  75. Dec 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9733930/
  77. www.science.org www.science.org
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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    science.org/doi/10.1126/sciadv.abq0648
  78. Nov 2022
  79. www.sciencedirect.com www.sciencedirect.com
    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    sciencedirect.com/science/article/pii/S1097276522009029
  80. www.sciencedirect.com www.sciencedirect.com
    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    sciencedirect.com/science/article/pii/S2211124722015443
  81. academic.oup.com academic.oup.com
    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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    academic.oup.com/narcancer/article/4/4/zcac036/6825304
  82. Jul 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow
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    ncbi.nlm.nih.gov/pmc/articles/PMC9271443/
  84. link.springer.com link.springer.com
    Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex
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    link.springer.com/article/10.1007/s12035-022-02936-x
  85. May 2022
  86. www.sciencedirect.com www.sciencedirect.com
    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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    sciencedirect.com/science/article/pii/S109727652200394X
  87. Mar 2022
  88. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    PTENα regulates endocytosis and modulates olfactory function
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201900588RR
  89. link.springer.com link.springer.com
    Partial p53 reactivation is sufficient to induce cancer regression
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    link.springer.com/article/10.1186/s13046-022-02269-6
  90. Jan 2022
  91. www.sciencedirect.com www.sciencedirect.com
    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    sciencedirect.com/science/article/pii/S2211124721017733
  92. www.sciencedirect.com www.sciencedirect.com
    Adaptive differentiation promotes intestinal villus recovery
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    sciencedirect.com/science/article/abs/pii/S1534580721010327
  93. Dec 2021
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
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    ncbi.nlm.nih.gov/pmc/articles/PMC8668188/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
  96. www.sciencedirect.com www.sciencedirect.com
    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    sciencedirect.com/science/article/pii/S2211124721015710
  97. Nov 2021
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8565929/
  99. Oct 2021
  100. link.springer.com link.springer.com
    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    link.springer.com/article/10.1186/s13046-021-02124-0
  101. www.sciencedirect.com www.sciencedirect.com
    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    sciencedirect.com/science/article/pii/S1097276521007474
  102. www.sciencedirect.com www.sciencedirect.com
    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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    sciencedirect.com/science/article/pii/S2211124721012304
  103. Sep 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521007395
  105. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521006833
  106. Aug 2021
  107. www.frontiersin.org www.frontiersin.org
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    frontiersin.org/article/10.3389/fnana.2014.00088/full
  108. www.cell.com www.cell.com
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    cell.com/molecular-cell/abstract/S1097-2765(17)30607-X
  109. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24683
  110. www.fasebj.org www.fasebj.org
    PTENα regulates endocytosis and modulates olfactory function
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    fasebj.org/doi/abs/10.1096/fj.201900588RR
  111. Jul 2021
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC6459675/
  113. www.sciencedirect.com www.sciencedirect.com
    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    sciencedirect.com/science/article/pii/S0896627319301151
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24683
  115. www.jneurosci.org www.jneurosci.org
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    jneurosci.org/content/34/37/12527
  116. www.sciencedirect.com www.sciencedirect.com
    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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    sciencedirect.com/science/article/pii/S2211124719311854
  117. www.sciencedirect.com www.sciencedirect.com
    The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
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    sciencedirect.com/science/article/pii/S1534580718307810
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5594246/
  119. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/160/4/827/5320257
  120. www.cell.com www.cell.com
    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00458-5
  121. Jun 2021
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
  123. May 2021
  124. www.sciencedirect.com www.sciencedirect.com
    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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