145 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts
    1
    1. scibot 09 Oct 2024
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      DOI: 10.1016/j.molcel.2024.09.020

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    sciencedirect.com/science/article/pii/S1097276524007767
  3. Sep 2024
  4. www.jneurosci.org www.jneurosci.org
    Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia
    1
    1. scibot 25 Sep 2024
      RRID:AB_10015219

      DOI: 10.1523/JNEUROSCI.2724-18.2019

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    jneurosci.org/content/39/29/5794
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.molcel.2024.07.018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1038/s41388-024-03094-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
  8. www.sciencedirect.com www.sciencedirect.com
    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114594

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    sciencedirect.com/science/article/pii/S2211124724009239
  9. Jul 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.jbc.2024.107492

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    sciencedirect.com/science/article/pii/S0021925824019938
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
    1. scibot 17 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114464

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    sciencedirect.com/science/article/pii/S2211124724007939
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
    1
    1. scibot 05 Jul 2024
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      DOI: 10.7554/eLife.83712

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    ncbi.nlm.nih.gov/pmc/articles/PMC11219039/
  13. May 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
    1
    1. scibot 17 May 2024
      RRID:AB_400326

      DOI: 10.3389/fncel.2024.1396780

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    ncbi.nlm.nih.gov/pmc/articles/PMC11091264/
  15. 52.53.155.43 52.53.155.43
    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.02.05.578390

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  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.molcel.2024.04.004

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    sciencedirect.com/science/article/pii/S109727652400282X
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
    1
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114006

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    ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
  19. Mar 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1038/s41467-024-45947-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  21. Feb 2024
  22. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1158/1078-0432.CCR-23-2005

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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  23. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113845

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    sciencedirect.com/science/article/pii/S2211124724001736
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA combing versus DNA spreading and the separation of sister chromatids
    2
    1. scibot 08 Feb 2024
      RRID: AB_400326

      DOI: 10.1083/jcb.202305082

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      DOI: 10.1083/jcb.202305082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
  25. Jan 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    1. scibot 24 Jan 2024
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      DOI: 10.1126/science.adi3448

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  27. www.sciencedirect.com www.sciencedirect.com
    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.025

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    sciencedirect.com/science/article/pii/S1097276523010717
  28. Dec 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
    1
    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.022

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    sciencedirect.com/science/article/pii/S009286742301276X
  30. www.sciencedirect.com www.sciencedirect.com
    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
    1
    1. scibot 21 Dec 2023
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      DOI: 10.1016/j.isci.2023.108564

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    sciencedirect.com/science/article/pii/S258900422302641X
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
    1
    1. scibot 13 Dec 2023
      RRID:AB_400326

      DOI: 10.7554/eLife.91263

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    ncbi.nlm.nih.gov/pmc/articles/PMC10712957/
  32. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1158/1078-0432.ccr-23-2005

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    52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
  33. Nov 2023
  34. link.springer.com link.springer.com
    Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli
    1
    1. scibot 25 Nov 2023
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      DOI: 10.1007/s12035-023-03746-5

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    link.springer.com/article/10.1007/s12035-023-03746-5
  35. Oct 2023
  36. www.sciencedirect.com www.sciencedirect.com
    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.isci.2023.108103

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    sciencedirect.com/science/article/pii/S2589004223021806
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.112845

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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  38. Aug 2023
  39. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    1. scibot 29 Aug 2023
      RRID:AB_400326

      DOI: 10.1126/science.adi3448

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    science.org/doi/10.1126/science.adi3448
  40. www.biorxiv.org www.biorxiv.org
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
    1
    1. scibot 27 Aug 2023
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      DOI: 10.1101/2023.08.21.554173

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    biorxiv.org/content/10.1101/2023.08.21.554173v1
  41. www.sciencedirect.com www.sciencedirect.com
    Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1
    1
    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.001

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    sciencedirect.com/science/article/abs/pii/S1097276523005154
  42. Jun 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
    1
    1. scibot 16 Jun 2023
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      DOI: 10.1016/j.molcel.2023.05.026

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    sciencedirect.com/science/article/pii/S1097276523003829
  44. May 2023
  45. www.science.org www.science.org
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
    1
    1. scibot 18 May 2023
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      DOI: 10.1126/sciadv.add8023

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    science.org/doi/10.1126/sciadv.add8023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
    1
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      DOI: 10.1126/sciadv.add8023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10171824/
  47. www.biorxiv.org www.biorxiv.org
    DNA Combing versus DNA Spreading and the Separation of Sister Chromatids
    3
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      DOI: 10.1101/2023.05.02.539129

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    biorxiv.org/content/10.1101/2023.05.02.539129v1
  48. www.sciencedirect.com www.sciencedirect.com
    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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      DOI: 10.1016/j.cell.2022.06.028

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    sciencedirect.com/science/article/pii/S0092867422007802
  49. Apr 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
    1
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      DOI: 10.1126/sciadv.ade7997

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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
  51. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
    1
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      DOI: 10.1126/sciadv.ade7997

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    science.org/doi/10.1126/sciadv.ade7997
  52. Jan 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.molcel.2022.12.034

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    sciencedirect.com/science/article/pii/S1097276522012175
  54. Dec 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
    1
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      DOI: 10.1126/sciadv.abq0648

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    ncbi.nlm.nih.gov/pmc/articles/PMC9733930/
  56. www.science.org www.science.org
    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
    1
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      DOI: 10.1126/sciadv.abq0648

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  57. Nov 2022
  58. www.sciencedirect.com www.sciencedirect.com
    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
    1
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    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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  61. Jul 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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  66. Mar 2022
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  72. Dec 2021
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    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  76. Nov 2021
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    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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  78. Oct 2021
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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  85. Aug 2021
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    PTENα regulates endocytosis and modulates olfactory function
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  90. Jul 2021
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    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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  102. May 2021
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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    Homology-directed repair protects the replicating genome from metabolic assaults
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  108. Feb 2021
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells
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    Role of GnRH isoforms in paracrine/autocrine control of zebrafish ( Danio rerio ) spermatogenesis
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    DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
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    EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
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  136. Jan 2020
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    Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    nature.com/articles/s41418-018-0225-1
  159. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
    1
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      RRID:AB_400326

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    sciencedirect.com/science/article/pii/S1097276518307858
  160. www.sciencedirect.com www.sciencedirect.com
    The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection
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      RRID:AB_400326

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  161. www.sciencedirect.com www.sciencedirect.com
    BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
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    sciencedirect.com/science/article/pii/S2211124718314050
  162. www.sciencedirect.com www.sciencedirect.com
    Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse
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    sciencedirect.com/science/article/pii/S009286741830905X
  163. www.sciencedirect.com www.sciencedirect.com
    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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    Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates
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    sciencedirect.com/science/article/pii/S2405471218302291
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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  166. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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  168. www.sciencedirect.com www.sciencedirect.com
    Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity
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  169. Nov 2017
  170. www.sciencedirect.com www.sciencedirect.com
    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
    1
    1. scibot 08 Nov 2017
      Mouse anti-BrdU Clone B44BD Transduction LaboratoriesCat# 347580

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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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  172. www.sciencedirect.com www.sciencedirect.com
    Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells
    1
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    sciencedirect.com/science/article/pii/S0896627317303057
  173. www.sciencedirect.com www.sciencedirect.com
    Serotonergic Projections Govern Postnatal Neuroblast Migration
    1
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      AB_400326

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  174. www.sciencedirect.com www.sciencedirect.com
    Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
    1
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      AB_400326

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  175. elifesciences.org elifesciences.org
    Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice
    1
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  176. www.jneurosci.org www.jneurosci.org
    In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation
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    jneurosci.org/content/36/42/10908.long
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two subunits of human ORC are dispensable for DNA replication and proliferation
    1
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      AB_400326

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC5245961/
  178. www.sciencedirect.com www.sciencedirect.com
    Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord
    1
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      AB_400326

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1044743116301579
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum
    1
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      AB_400326

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC4157608/
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wls Provides a New Compartmental View of the Rhombic Lip in Mouse Cerebellar Development
    1
    1. scibot 08 Nov 2017
      AB_400326

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC4160781/