273 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
    1
    1. scibot 08 Nov 2024
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      DOI: 10.1158/0008-5472.CAN-24-0134

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
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    1. scibot 25 Sep 2024
      RRID:AB_1001296

      DOI: 10.1016/j.chembiol.2019.12.006

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    sciencedirect.com/science/article/pii/S2451945619304027
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    Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis
    1
    1. scibot 25 Sep 2024
      RRID:AB_2616028

      DOI: 10.1016/j.celrep.2019.10.127

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    sciencedirect.com/science/article/pii/S2211124719314603
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells
    1
    1. scibot 13 Sep 2024
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      DOI: 10.3390/ijms25168595

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    ncbi.nlm.nih.gov/pmc/articles/PMC11354993/
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    Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway
    1
    1. scibot 12 Sep 2024
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      DOI: 10.1016/j.abb.2024.110153

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    sciencedirect.com/science/article/pii/S0003986124002753
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    A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2451945624003234
  9. Aug 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
    1
    1. scibot 28 Aug 2024
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    sciencedirect.com/science/article/pii/S1534580724004866
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    Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
    1
    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1074761324003686
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    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2589004224017759
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
    1
    1. scibot 21 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
    1
    1. scibot 18 Aug 2024
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  15. Jul 2024
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    Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells
    1
    1. scibot 26 Jul 2024
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      DOI: 10.1016/j.devcel.2024.06.015

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    sciencedirect.com/science/article/pii/S1534580724003939
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    Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.stem.2024.06.015

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    sciencedirect.com/science/article/pii/S1934590924002509
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.molcel.2020.09.028

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    ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
    1
    1. scibot 14 Jul 2024
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      DOI: 10.1016/j.isci.2024.110144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
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    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
    1
    1. scibot 12 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114477

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    sciencedirect.com/science/article/pii/S2211124724008064
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization
    1
    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.05.597552

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    ncbi.nlm.nih.gov/pmc/articles/PMC11185714/
  22. Jun 2024
  23. link.springer.com link.springer.com
    Electro-elution-based purification of covalent DNA–protein cross-links
    1
    1. scibot 28 Jun 2024
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      DOI: 10.1038/s41596-024-01004-z

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    link.springer.com/article/10.1038/s41596-024-01004-z
  24. www.sciencedirect.com www.sciencedirect.com
    Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.009

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    sciencedirect.com/science/article/pii/S1534580724003265
  25. May 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
    2
    1. scibot 31 May 2024
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      DOI: 10.1016/j.immuni.2024.05.006

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    2. scibot 31 May 2024
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      DOI: 10.1016/j.immuni.2024.05.006

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    sciencedirect.com/science/article/pii/S1074761324002590
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    Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response
    1
    1. scibot 30 May 2024
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      DOI: 10.1016/j.ebiom.2024.105162

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    sciencedirect.com/science/article/pii/S235239642400197X
  28. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
    1
    1. scibot 30 May 2024
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      DOI: 10.1038/s41416-024-02697-5

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    nature.com/articles/s41416-024-02697-5
  29. www.sciencedirect.com www.sciencedirect.com
    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
    1
    1. scibot 27 May 2024
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      DOI: 10.1016/j.celrep.2021.108891

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    sciencedirect.com/science/article/pii/S2211124721002059
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes
    1
    1. scibot 17 May 2024
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      DOI: 10.1038/s44319-024-00140-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094177/
  31. www.sciencedirect.com www.sciencedirect.com
    Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration
    1
    1. scibot 03 May 2024
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      DOI: 10.1016/j.cell.2024.04.005

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    sciencedirect.com/science/article/pii/S0092867424004008
  32. Apr 2024
  33. www.sciencedirect.com www.sciencedirect.com
    6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model
    1
    1. scibot 23 Apr 2024
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    sciencedirect.com/science/article/pii/S0006295224002132
  34. aacrjournals.org aacrjournals.org
    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-1459

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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
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    1. scibot 05 Apr 2024
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      DOI: 10.1038/s41598-024-57926-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10994939/
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    Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114065

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    sciencedirect.com/science/article/pii/S2211124724003930
  37. Mar 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases
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      DOI: 10.1158/2767-9764.CRC-23-0090

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    ncbi.nlm.nih.gov/pmc/articles/PMC10977041/
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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      DOI: 10.1016/j.xcrm.2024.101468

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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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      DOI: 10.4103/1673-5374.389302

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    ncbi.nlm.nih.gov/pmc/articles/PMC10960275/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate
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      DOI: 10.7554/eLife.89015

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957176/
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    sciencedirect.com/science/article/pii/S1550413124000500
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  44. Feb 2024
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    Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons
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      DOI: 10.1016/j.isci.2024.109166

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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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  143. Jun 2022
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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    Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
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    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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    High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
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  151. May 2022
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    H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer
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    Mucus sialylation determines intestinal host-commensal homeostasis
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion
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    Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
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    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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    TRIB3 is highly expressed in the adipose tissue of obese patients and is associated with insulin resistance
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    KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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    MATISSE: An analysis protocol for combining imaging mass cytometry with fluorescence microscopy to generate single-cell data
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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    Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment
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    Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
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    Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation
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    Cell geometry, signal dampening, and a bimodal transcriptional response underlie the spatial precision of an ERK-mediated embryonic induction
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      DOI: 10.1016/j.cell.2021.03.032

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      DOI: 10.1016/j.mce.2021.111264

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      DOI: 10.1016/j.molcel.2021.03.009

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