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Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis

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  DOI: 10.1016/j.cmet.2025.09.015
  
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Oct 2025
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2025.09.25.678487v1.full-html.html

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  DOI: 10.1101/2025.09.25.678487
  
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CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis

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  DOI: 10.1016/j.celrep.2025.116351
  
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Sep 2025
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2025.09.03.674035v1.full-html.html

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52.53.155.43/37963928bc5aea98c91b74412d9eea47b89c8e40/2025.09.03.674035v1.full-html.html
Aug 2025
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Design of multi-target peptide modulators for protein chaperone networks

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  DOI: 10.1016/j.str.2025.07.021
  
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sciencedirect.com/science/article/pii/S0969212625002692
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YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

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  DOI: 10.1016/j.celrep.2025.116188
  
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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  DOI: 10.1016/j.devcel.2025.07.016
  
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Jul 2025
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Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity

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Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html

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52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
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Site-resolved assessment of targeted protein degradation

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  DOI: 10.1016/j.chembiol.2025.06.002
  
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Jun 2025
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Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation

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  DOI: 10.1152/ajpcell.00776.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12168846/
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Pyruvate kinase M2 (PKM2) tetramerization protects against hepatic stellate cell activation and liver fibrosis

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Apr 2025
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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.015
  
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Mar 2025
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Sphingolipids Regulate Neuromuscular Synapse Structure and function in Drosophila

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  DOI: 10.1002/cne.24466
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6175220/
Dec 2024
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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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1. scibot 11 Dec 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01495
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11624864/
Nov 2024
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SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release

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1. scibot 14 Nov 2024
  
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  DOI: 10.1038/s44319-024-00250-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11549447/
Sep 2024
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Su(var)2-10 and the SUMO Pathway Link piRNA-Guided Target Recognition to Chromatin Silencing

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sciencedirect.com/science/article/pii/S109727651930841X
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Multiple direct and indirect roles of the Paf1 complex in transcription elongation, splicing, and histone modifications

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Aug 2024
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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sciencedirect.com/science/article/pii/S1074761324003595
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Untitled document

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  DOI: 10.21769\u002FBioProtoc.2222
  
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Jun 2024
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Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity

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  DOI: 10.1016/j.chom.2024.04.012
  
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May 2024
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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

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Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma

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  DOI: 10.1016/j.xcrm.2024.101519
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00188-5
Apr 2024
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Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

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  DOI: 10.7554/eLife.92243
  
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Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury

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Generation of human cerebral organoids with a structured outer subventricular zone

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Mar 2024
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Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

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  DOI: 10.7554/eLife.92342
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10957175/
Jan 2024
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Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis

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  DOI: 10.1002/ptr.8130
  
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onlinelibrary.wiley.com/doi/10.1002/ptr.8130
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Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting

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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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  DOI: 10.1158/2159-8290.CD-22-1301
  
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aacrjournals.org/cancerdiscovery/article/13/12/2566/731588/Formate-Supplementation-Enhances-Antitumor-CD8-T
Dec 2023
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Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae

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  DOI: 10.1016/j.celrep.2023.113599
  
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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

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  DOI: 10.1016/j.chembiol.2023.11.010
  
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cd-22-1301-html.html

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  DOI: 10.1158/2159-8290.cd-22-1301
  
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Sep 2023
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Essential role of the amino-terminal region of Drosha for the Microprocessor function

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Aug 2023
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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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Jul 2023
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Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

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Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice

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Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery

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Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response

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Mar 2023
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An optimized protocol to detect protein ubiquitination and activation by ubiquitination assay in vivo and CCK-8 assay

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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes

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Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

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Mechanism of IFT-A polymerization into trains for ciliary transport

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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

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Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury

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Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

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Methionine metabolism controls the B cell EBV epigenome and viral latency

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Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin-expressing interneurons, and inhibitory function in the auditory cortex

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A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand

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Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice

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β-catenin links cell seeding density to global gene expression during mouse embryonic stem cell differentiation

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Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

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PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

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Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Untitled document

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Untitled document

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Jul 2021
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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

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TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.

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The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

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Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms

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A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form

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Constitutive androstane receptor induced-hepatomegaly is partially via yes-associated protein activation

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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

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FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

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Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease

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E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

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Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

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Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

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Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

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Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

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Molecular Basis of Zinc-Dependent Endocytosis of Human ZIP4 Transceptor

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Donepezil‐induced oligodendrocyte differentiation is mediated through estrogen receptors

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

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Efficient Generation of Multi-gene Knockout Cell Lines and ...

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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

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Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

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Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9 —BIO-PROTOCOL

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Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

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