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Domain-autonomous MKLP1 modules divergently regulate mitotic fidelity and polyploidy in a holocentric system

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  DOI: 10.1016/j.isci.2026.117149
  
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Sep 2026
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HRAS promotes mutant NRAS–driven transformation with codon and allele specificity

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1. scibot 12 Sep 2026
  
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  DOI: 10.1126/scisignal.aej6209
  
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Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosis

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Aug 2026
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The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models

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Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma

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1. scibot 27 Aug 2026
  
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54.241.53.176/ac55aaa7dd054e10d1ec78375f1460fa75afc780/2025.11.11.687869.full-html.html
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EGFR inhibition promotes functional engraftment and graft survival via donor-derived CHI3L1 in fetal RPE suspension transplantation

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Repurposing simeprevir uncovers a druggable KPNB1-p65-BCL2 survival axis in cancer

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Jul 2026
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Investigating the role of baseline gut Akkermansia muciniphila and its co-metabolite palmitoleic acid in BCG vaccine efficacy: a preclinical study

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ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment

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IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

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1. scibot 12 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-2313
  
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aacrjournals.org/cancerres/article/86/8/2004/782636/IDH1-Reprograms-Nucleotide-Metabolism-by-Inducing
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DDIT3, OTUB2, and ASS1 regulate arginine biosynthesis in colorectal cancer cells under arginine deficiency

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Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

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1. scibot 11 Jul 2026
  
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aacrjournals.org/cancerres/article/85/18/3416/764453/Mitochondrial-Calcium-Uniporter-Links-Acetyl-CoA
Jun 2026
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Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathies

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1. scibot 26 Jun 2026
  
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  DOI: 10.64898/2026.06.10.731336
  
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DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma

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  DOI: 10.1038/s41388-026-03845-2
  
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An X-to-autosome-to-Y chromosome amplified retrogene family functions in spermatids

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1. scibot 10 Jun 2026
  
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  DOI: 10.1016/j.cub.2026.04.045
  
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3-Hydroxypropionic acid converts inflammatory macrophage glycolysis into mitochondrial oxidation through GAPDH carboxyethylation

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  DOI: 10.1016/j.isci.2026.116258
  
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STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer

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1. scibot 05 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102844
  
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A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer

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AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling

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  DOI: 10.1016/j.celrep.2026.117394
  
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May 2026
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Design principles of a membrane-spanning ubiquitin ligase

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Farnesylation-driven KRAS phase separation promotes colon tumor growth

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Dual proximity-based interactome mapping of FKBP51 and FKBP52 uncovers shared metabolic networks

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ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling

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1. scibot 22 May 2026
  
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Protein craving links larval signals to food provisioning in honey bees

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  DOI: 10.1126/sciadv.aec3855
  
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Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

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DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3728
  
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The key regulator circ_0003295 promotes arsenic-induced lung carcinogenesis and progression by enhancing mitochondrial function

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  DOI: 10.1016/j.ecoenv.2026.120233
  
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Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity

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Apr 2026
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Supplementary file-html.html

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  DOI: 10.1158/2159-8290.CD-25-1123
  
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EYA4 promotes cellular senescence by enhancing P21 transcription through interaction with SIX2

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  DOI: 10.1007/s44307-026-00109-8
  
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Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function

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  DOI: 10.1016/j.isci.2026.115398
  
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Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin

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Chaperonin TRiC bridges radial spokes for folding locally translated proteins to sustain mammalian sperm flagellar motility

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Mar 2026
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Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers

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1. scibot 18 Mar 2026
  
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  DOI: 10.1126/scisignal.adx5186
  
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AARS1-mediated lactylation of STAT1 drives immune evasion

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117094
  
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Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

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Regulation of mitophagy by Fis1 and Fascin1-organized actin

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HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer

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Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer

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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

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HMOX1 drives dihydroartemisinin-sensitized ferroptosis antagonized by mitochondrial fusion

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A gut-secreted histidine methyltransferase enforces cross-kingdom catalytic antifungal defense

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METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer

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Identification of ATG7 as a protein ATG8ylation substrate

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Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

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A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics

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HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer

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Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response

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Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface

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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression

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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice

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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes

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PKA-mediated BMAL1 phosphorylation promotes β1-adrenoceptor autoantibody-induced cardiomyocyte death

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Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain

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Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression

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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

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Mechanobiological mechanism of cyclic stretch-induced cell columnarization

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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity

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Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body

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Feb 2025
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Downregulation of BASP1 promotes temozolomide resistance in gliomas via epigenetic activation of the FBXO32/NF-κB/MGMT axis

1
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  RRID:AB_11042766
  
  DOI: 10.1158/1541-7786.MCR-22-1012
  
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Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP

1
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  DOI: 10.1016/j.celrep.2025.115297
  
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Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma

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  DOI: 10.1158/0008-5472.CAN-24-1095
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004225002330-main-html.html

1
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  DOI: 10.1016/j.isci.2025.111973
  
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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  DOI: 10.1016/j.celrep.2025.115250
  
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Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming

1
1. scibot 24 Jan 2025
  
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  RRID:AB_11042766
  
  DOI: 10.1242/dev.204329
  
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1-s2.0-S2589004225001142-main-html.html

1
1. scibot 23 Jan 2025
  
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  RRID:AB_110427
  
  DOI: 10.1016/j.isci.2025.111854
  
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Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

1
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  RRID:AB_11042766
  
  DOI: 10.7554/eLife.100205
  
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Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer

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  DOI: 10.1016/j.isci.2024.111612
  
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Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3

1
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  DOI: 10.1016/j.immuni.2024.11.020
  
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

1
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  DOI: 10.1038/s41586-024-08348-2
  
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1-s2.0-S2589004224028670-main-html.html

1
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  AB_11042766
  
  DOI: 10.1016/j.isci.2024.111640
  
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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

1
1. scibot 05 Dec 2024
  
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  RRID:AB_11042766
  
  DOI: 10.1038/s44318-024-00276-1
  
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Opposing roles for AMPK in regulating distinct mitophagy pathways

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  DOI: 10.1016/j.molcel.2024.10.025
  
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The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

1
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  DOI: 10.7554/eLife.94657
  
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Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

1
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  RRID:AB_11042766
  
  DOI: 10.3390/cells13191654
  
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Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females

1
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  AB_11042766
  
  DOI: 10.1210/endocr/bqae045
  
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Sep 2024
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PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2687491
  
  DOI: 10.1016/j.celrep.2020.108312
  
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Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis

1
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  RRID:AB_477593
  
  DOI: 10.1016/j.celrep.2019.10.127
  
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EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells

1
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  DOI: 10.3390/ijms25168595
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11354993/
Aug 2024
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Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

1
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  DOI: 10.7554/eLife.92826
  
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Acetate enables metabolic fitness and cognitive performance during sleep disruption

1
1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.019
  
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Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model

1
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  DOI: 10.1016/j.neuron.2024.07.013
  
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Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients

1
1. scibot 02 Aug 2024
  
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  66031
  
  DOI: 10.1186/s13046-021-02166-4
  
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Jul 2024
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Assembly mechanism of Integrator’s RNA cleavage module

1
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  DOI: 10.1016/j.molcel.2024.06.032
  
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52.53.155.43 52.53.155.43

Cancer-associated endocrine cells participate in pancreatic carcinogenesis

1
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  RRID:AB_11042766
  
  DOI: 10.1053/j.gastro.2024.07.016
  
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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

1
1. scibot 18 Jul 2024
  
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  RRID:AB_11042766
  
  DOI: 10.1038/s41422-024-00985-6
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004224017310-main-html.html

1
1. scibot 16 Jul 2024
  
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  AB_11042766
  
  DOI: 10.1016/j.isci.2024.110506
  
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A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer’s disease

1
1. scibot 10 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.109778
  
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Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

1
1. scibot 03 Jul 2024
  
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  RRID:AB_28834830
  
  DOI: 10.3389/fonc.2024.1394653
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
Jun 2024
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O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy

1
1. scibot 22 Jun 2024
  
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  RRID:AB_11042766
  
  DOI: 10.3390/ijms25116286
  
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IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance

1
1. scibot 08 Jun 2024
  
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  RRID:AB_11042766
  
  DOI: 10.1016/j.isci.2024.109917
  
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May 2024
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Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release

1
1. scibot 19 May 2024
  
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  RRID:AB_11042766
  
  DOI: 10.1126/sciadv.adi7024
  
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

1
1. scibot 17 May 2024
  
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  RRID:AB_11042766
  
  DOI: 10.1016/j.molcel.2024.04.009
  
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Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

1
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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins

1
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Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

1
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The activation of LBH-CRYAB signaling promotes cardiac protection against ischemia-reperfusion injury by inhibiting apoptosis and ferroptosis

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Genetic interactions reveal distinct biological and therapeutic implications in breast cancer

1
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Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy

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Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways

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p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

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ULK phosphorylation of STX17 controls autophagosome maturation via FLNA

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Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells

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Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation

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FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation

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can-23-1065-html.html

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Oct 2023
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Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

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Aug 2023
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PIIS221112472300952X-html.html

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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy

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The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury

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Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

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Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice

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Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics

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  DOI: 10.15252/embr.202256538
  
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Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin

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IL-17C neutralization protects the kidney against acute injury and chronic injury

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May 2023
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mcr-22-1012-html.html

1
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Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus

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  DOI: 10.1038/s41420-023-01445-7
  
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Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus

1
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Mar 2023
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Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates

1
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Jan 2023
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Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion

1
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Dec 2022
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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

2
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  DOI: 10.15252/embj.2022111961
  
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  DOI: 10.15252/embj.2022111961
  
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Nov 2022
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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease

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  DOI: 10.1016/j.neuron.2022.10.021
  
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Oct 2022
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D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia

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  DOI: 10.1016/j.isci.2022.105263
  
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Sep 2022
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Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity

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Aug 2022
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Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis

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May 2022
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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

1
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Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

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Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function

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Hexokinase 1 cellular localization regulates the metabolic fate of glucose

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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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Recycling of autophagosomal components from autolysosomes by the recycler complex

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Mar 2022
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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

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Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

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Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium

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Methylation of dual-specificity phosphatase 4 controls cell differentiation

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Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low‐dose cisplatin exposure

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Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense

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  Anti-Tubulin
  
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Jun 2021
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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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May 2021
journals.biologists.com journals.biologists.com

Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor

1
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Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis

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Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

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Dec 2020
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CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes

1
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  DOI: 10.1016/j.phrs.2020.105333
  
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Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation

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Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer

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MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

1
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Hepatic HKDC1 Expression Contributes to Liver Metabolism

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Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

1
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  DOI: 10.7554/eLife.50850
  
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Untitled document

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Untitled document

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BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

1
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Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

1
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AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity

1
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sciencedirect.com/science/article/pii/S1550413118301323
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5807059/
europepmc.org europepmc.org

Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:AB_11042766
  
  Curator: @evieth
  
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europepmc.org/articles/PMC5739542/
Nov 2017
academic.oup.com academic.oup.com

IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells

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1. scibot 08 Nov 2017
  
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  Curator: @patriciaelyse_
  
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academic.oup.com/endo/article/158/10/3281/3885816/IL-1-Upregulates-StAR-and-Progesterone-Production

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