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  1. Last 7 days
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    Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices
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    sciencedirect.com/science/article/pii/S266729012400024X
  3. Apr 2024
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    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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      DOI: 10.1101/2024.04.07.588476

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    biorxiv.org/content/10.1101/2024.04.07.588476v1
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
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    2. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004017
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    Conditional dependency of LP-184 on prostaglandin reductase 1 is synthetic lethal in pancreatic cancers with DNA damage repair deficiencies.
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    1. scibot 03 Apr 2024
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      DOI: 10.1158/1535-7163.MCT-22-0818

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592171/
  7. Mar 2024
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    Female mice display sex-specific differences in cerebrovascular function and subarachnoid haemorrhage-induced injury
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    1. scibot 20 Mar 2024
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      DOI: 10.1016/j.ebiom.2024.105058

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    2. scibot 20 Mar 2024
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00093-8/abstract
  9. 52.53.155.43 52.53.155.43
    Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin
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      DOI: 10.1007/s11427-023-2444-5

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    52.53.155.43/87ec0518c5224f0fd07557d79aa684b0e2f086c0/s11427-023-2444-5 (1)-html.html
  10. Feb 2024
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    Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development
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    sciencedirect.com/science/article/pii/S2589004224004012
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    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.immuni.2024.02.002

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    sciencedirect.com/science/article/pii/S1074761324000773
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    1. scibot 16 Feb 2024
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
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    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
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    1. scibot 14 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724000664
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    Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation
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    1. scibot 09 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724000743
  16. Jan 2024
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    1. scibot 11 Jan 2024
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    sciencedirect.com/science/article/pii/S1097276523010298
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    Cytoneme signaling provides essential contributions to mammalian tissue patterning
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    sciencedirect.com/science/article/pii/S0092867423013338
  19. Dec 2023
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    sciencedirect.com/science/article/pii/S245194562300421X
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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    sciencedirect.com/science/article/pii/S221112472301553X
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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      DOI: 10.1016/j.immuni.2023.11.002

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    sciencedirect.com/science/article/pii/S1074761323004831
  23. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276523008547
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    Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells
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      DOI: 10.1101/2023.11.12.566736

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    biorxiv.org/content/10.1101/2023.11.12.566736v1
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    The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing
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    1. scibot 03 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113347

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    sciencedirect.com/science/article/pii/S2211124723013591
  27. Sep 2023
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    TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
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      DOI: 10.1016/j.stem.2023.07.001

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    sciencedirect.com/science/article/pii/S1934590923002461
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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      DOI: 10.1016/j.celrep.2023.113070

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    sciencedirect.com/science/article/pii/S2211124723010811
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development
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      DOI: 10.1016/j.isci.2023.107474

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    ncbi.nlm.nih.gov/pmc/articles/PMC10424150/
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enzymatic assay for UDP-GlcNAc and its application in the parallel assessment of substrate availability and protein O-GlcNAcylation
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      DOI: 10.1016/j.crmeth.2023.100518

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    ncbi.nlm.nih.gov/pmc/articles/PMC10391344/
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals
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      DOI: 10.1016/j.xgen.2023.100349

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    sciencedirect.com/science/article/pii/S2666979X23001246
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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      DOI: 10.1111/jnc.15877

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15877
  37. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
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    MAP4K4 is involved in the neuronal development of retinal photoreceptors
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    1. scibot 08 Jun 2023
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    sciencedirect.com/science/article/pii/S0014483523001458
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    Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models
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      DOI: 10.1016/j.xcrm.2023.101070

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    sciencedirect.com/science/article/pii/S2666379123001891
  40. May 2023
  41. www.sciencedirect.com www.sciencedirect.com
    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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      DOI: 10.1016/j.celrep.2023.112496

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    sciencedirect.com/science/article/pii/S2211124723005077
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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      DOI: 10.1016/j.celrep.2023.112447

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    sciencedirect.com/science/article/pii/S2211124723004588
  43. Apr 2023
  44. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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      DOI: 10.1016/j.xcrm.2023.101015

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    sciencedirect.com/science/article/pii/S2666379123001258
  45. 52.53.155.43 52.53.155.43
    Boosting BDNF in muscle rescues impaired in vivo axonal transport in a mouse model of DI-CMTC peripheral neuropathy
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    52.53.155.43/ba037e3ddb407a632c90700d00589d963ca410f7/2023.04.09.536152v1.full-html.html
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10054615/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation
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      DOI: 10.1016/j.isci.2023.106314

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    ncbi.nlm.nih.gov/pmc/articles/PMC10064239/
  48. Mar 2023
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
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      DOI: 10.1016/j.isci.2023.106297

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    ncbi.nlm.nih.gov/pmc/articles/PMC10025987/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
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    1. scibot 16 Mar 2023
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      DOI: 10.7554/eLife.84708

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    ncbi.nlm.nih.gov/pmc/articles/PMC9998091/
  51. www.biorxiv.org www.biorxiv.org
    Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models
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      DOI: 10.1101/2023.02.23.529773

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    biorxiv.org/content/10.1101/2023.02.23.529773v1
  52. Feb 2023
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    Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
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    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
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    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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  56. Jan 2023
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    Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
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  58. Dec 2022
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors
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  61. Nov 2022
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    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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  65. Oct 2022
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    Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway
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    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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    Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
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    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
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  70. Sep 2022
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    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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  72. Aug 2022
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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  82. May 2022
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    EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
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  88. Mar 2022
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    Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response
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  93. Jan 2022
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    Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
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    The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
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  97. Dec 2021
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  99. Oct 2021
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    MEC17 Induced α-tubulin Acetylation Restores Mitochondrial Transport Function and Alleviates Axonal Injury after Intracerebral Hemorrhage in Mice
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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  104. Aug 2021
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    Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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  136. Feb 2021
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  144. Sep 2020
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  149. Jan 2020
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    The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
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    Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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    ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
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    Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
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    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
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    Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer
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  183. Nov 2017
  184. www.sciencedirect.com www.sciencedirect.com
    GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia
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    Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
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    Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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    Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation
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    ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation
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