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Jun 2025
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Functional assessment of all ATM SNVs using prime editing and deep learning

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.046
  
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Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss

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1. scibot 23 Jun 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0506
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12179588/
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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2767-9764.crc-24-0506
  
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52.53.155.43/57fca004bcca4ef73bc4f20824e92935b6a3b58f/PDF-html.html
May 2025
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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jare.2025.04.033
  
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sciencedirect.com/science/article/pii/S2090123225002772
Apr 2025
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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1. scibot 16 Apr 2025
  
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  DOI: 10.1038/s41419-025-07624-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
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Halting hepatocellular carcinoma: Identifying intercellular crosstalk in HBV-driven disease

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115457
  
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sciencedirect.com/science/article/pii/S2211124725002281
Mar 2025
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 14 Mar 2025
  
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  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

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1. scibot 08 Mar 2025
  
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  DOI: 10.1038/s41467-025-57229-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882782/
Jan 2025
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

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1. scibot 15 Jan 2025
  
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  DOI: 10.1038/s41467-024-55667-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11711318/
Dec 2024
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Mapping functional elements of the DNA damage response through base editor screens

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115047
  
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sciencedirect.com/science/article/pii/S2211124724013986
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

1
1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111283
  
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sciencedirect.com/science/article/pii/S2589004224025082
Sep 2024
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

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1. scibot 25 Sep 2024
  
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  RRID:AB_1904178
  
  DOI: 10.1016/j.cell.2019.05.036
  
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sciencedirect.com/science/article/pii/S0092867419305641
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Protein UFMylation regulates early events during ribosomal DNA-damage response

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114738
  
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sciencedirect.com/science/article/pii/S2211124724010891
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Jul 2024
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Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

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1. scibot 23 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114497
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00826-X
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
Jun 2024
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The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114366
  
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sciencedirect.com/science/article/pii/S2211124724006946
May 2024
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

1
1. scibot 02 May 2024
  
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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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1. scibot 25 Apr 2024
  
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  DOI: 10.1083/jcb.202303141
  
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2. scibot 25 Apr 2024
  
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  RRID:AB_2062659
  
  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
Mar 2024
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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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1. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113975
  
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2. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113975
  
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sciencedirect.com/science/article/pii/S2211124724003036
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Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00089-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

2
1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.010
  
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2. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.010
  
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sciencedirect.com/science/article/pii/S1097276524001291
Feb 2024
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RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108925
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.biopha.2024.116217
  
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sciencedirect.com/science/article/pii/S0753332224000982
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101376
  
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sciencedirect.com/science/article/pii/S2666379123006055
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108659
  
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sciencedirect.com/science/article/pii/S2589004223027360
Nov 2023
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Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.scr.2023.103247
  
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sciencedirect.com/science/article/pii/S1873506123002337
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ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress

1
1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113402
  
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sciencedirect.com/science/article/pii/S2211124723014146
Oct 2023
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Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.phymed.2023.155126
  
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sciencedirect.com/science/article/pii/S0944711323004865
Aug 2023
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SSRN-id4513724-html.html

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1. scibot 10 Aug 2023
  
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  DOI: 10.2139/ssrn.4513724
  
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52.53.155.43/5f78fb6f419d1fcb5e4cfbd3ef5a02650af33ba6/SSRN-id4513724-html.html
Jul 2023
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.025
  
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sciencedirect.com/science/article/pii/S1097276523004720
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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.007
  
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sciencedirect.com/science/article/pii/S1535610823002179
Apr 2023
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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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1. scibot 20 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112400
  
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway

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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

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CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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Untitled document

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Untitled document

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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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Bacterial genotoxins induce T cell senescence

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Functional interrogation of DNA damage response variants with base editing screens

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Systematic characterization of mutations altering protein degradation in human cancers

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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness

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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

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MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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  DOI: 10.1016/j.ccell.2019.09.004
  
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  DOI: 10.1016/j.ccell.2019.01.020
  
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Untitled document

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  DOI: 10.1016/j.molcel.2018.11.001
  
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Nov 2018
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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells

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1. scibot 05 Nov 2018
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

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Nov 2017
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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

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