70 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
    1
    1. scibot 15 Nov 2024
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      DOI: 10.1016/j.isci.2024.111283

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    sciencedirect.com/science/article/pii/S2589004224025082
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
    1
    1. scibot 25 Sep 2024
      RRID:AB_1904178

      DOI: 10.1016/j.cell.2019.05.036

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    sciencedirect.com/science/article/pii/S0092867419305641
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    Protein UFMylation regulates early events during ribosomal DNA-damage response
    1
    1. scibot 17 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114738

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    sciencedirect.com/science/article/pii/S2211124724010891
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    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.013

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    sciencedirect.com/science/article/pii/S0092867424009048
  7. Jul 2024
  8. www.cell.com www.cell.com
    Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
    1
    1. scibot 23 Jul 2024
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2024.114497

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    cell.com/cell-reports/fulltext/S2211-1247(24)00826-X
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
    1
    1. scibot 14 Jul 2024
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      DOI: 10.1016/j.isci.2024.110144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
  10. Jun 2024
  11. www.sciencedirect.com www.sciencedirect.com
    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
    1
    1. scibot 21 Jun 2024
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2024.114366

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    sciencedirect.com/science/article/pii/S2211124724006946
  12. May 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
    1
    1. scibot 02 May 2024
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      DOI: 10.1016/j.xgen.2024.100550

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
  14. Apr 2024
  15. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
    1. scibot 25 Apr 2024
      RRID:AB_2062659

      DOI: 10.1083/jcb.202303141

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    2. scibot 25 Apr 2024
      RRID:AB_2062659

      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  16. Mar 2024
  17. www.sciencedirect.com www.sciencedirect.com
    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
    2
    1. scibot 22 Mar 2024
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2024.113975

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      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
    1
    1. scibot 16 Mar 2024
      RRID:AB_2062659

      DOI: 10.1038/s44319-024-00089-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  19. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2024.02.010

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    2. scibot 08 Mar 2024
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
  20. Feb 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
    1. scibot 08 Feb 2024
      RRID:AB_2062659

      DOI: 10.1016/j.isci.2024.108925

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  22. www.sciencedirect.com www.sciencedirect.com
    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
    1
    1. scibot 02 Feb 2024
      RRID:AB_2062659

      DOI: 10.1016/j.biopha.2024.116217

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    sciencedirect.com/science/article/pii/S0753332224000982
  23. Jan 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    1
    1. scibot 19 Jan 2024
      RRID:AB_2062659

      DOI: 10.1016/j.xcrm.2023.101376

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    sciencedirect.com/science/article/pii/S2666379123006055
  25. Dec 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
      RRID:AB_2062659

      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  27. Nov 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia
    1
    1. scibot 17 Nov 2023
      RRID:AB_2062659

      DOI: 10.1016/j.scr.2023.103247

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    sciencedirect.com/science/article/pii/S1873506123002337
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    ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
    1
    1. scibot 17 Nov 2023
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2023.113402

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    sciencedirect.com/science/article/pii/S2211124723014146
  30. Oct 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
    1
    1. scibot 13 Oct 2023
      RRID:AB_2062659

      DOI: 10.1016/j.phymed.2023.155126

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    sciencedirect.com/science/article/pii/S0944711323004865
  32. Aug 2023
  33. 52.53.155.43 52.53.155.43
    SSRN-id4513724-html.html
    1
    1. scibot 10 Aug 2023
      RRID:AB_2062659

      DOI: 10.2139/ssrn.4513724

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    52.53.155.43/5f78fb6f419d1fcb5e4cfbd3ef5a02650af33ba6/SSRN-id4513724-html.html
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
    1
    1. scibot 21 Jul 2023
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2023.06.025

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    sciencedirect.com/science/article/pii/S1097276523004720
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    1. scibot 14 Jul 2023
      RRID:AB_2062659

      DOI: 10.1016/j.ccell.2023.06.007

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    sciencedirect.com/science/article/pii/S1535610823002179
  37. Apr 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
    1
    1. scibot 20 Apr 2023
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2023.112400

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    sciencedirect.com/science/article/pii/S2211124723004114
  39. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
    1
    1. scibot 19 Apr 2023
      RRID:AB_2062659

      DOI: 10.1016/j.xcrm.2023.101015

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    sciencedirect.com/science/article/pii/S2666379123001258
  40. Mar 2023
  41. link.springer.com link.springer.com
    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
    1
    1. scibot 17 Mar 2023
      RRID:AB_2062659

      DOI: 10.1007/s13402-023-00793-x

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    link.springer.com/article/10.1007/s13402-023-00793-x
  42. Nov 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
    1
    1. scibot 09 Nov 2022
      RRID:AB_2062659

      DOI: 10.1016/j.isci.2022.105342

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    ncbi.nlm.nih.gov/pmc/articles/PMC9633742/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
    1
    1. scibot 04 Nov 2022
      RRID:AB_2062659

      DOI: 10.1016/j.isci.2022.105352

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    ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
  45. Oct 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
    1
    1. scibot 12 Oct 2022
      RRID:AB_2062659

      DOI: 10.1128/jvi.02028-21

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    ncbi.nlm.nih.gov/pmc/articles/PMC9044952/
  47. May 2022
  48. www.sciencedirect.com www.sciencedirect.com
    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
    1
    1. scibot 20 May 2022
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
  49. www.cell.com www.cell.com
    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
    1
    1. scibot 05 May 2022
      RRID:AB_2062659

      DOI: 10.1016/j.cell.2022.04.014

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    cell.com/cell/fulltext/S0092-8674(22)00461-5
  50. Apr 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
    1
    1. scibot 27 Apr 2022
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2022.03.034

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    sciencedirect.com/science/article/pii/S1097276522002908
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
    1
    1. scibot 05 Apr 2022
      RRID:AB_2062659

      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  53. Mar 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
    1
    1. scibot 09 Mar 2022
      RRID:AB_2062659

      DOI: 10.1016/j.isci.2022.103912

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    sciencedirect.com/science/article/pii/S2589004222001821
  55. Jan 2022
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
    1
    1. scibot 22 Jan 2022
      RRID:AB_2062659

      DOI: 10.3390/cancers14020326

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
    1. scibot 05 Jan 2022
      RRID:AB_2062659

      DOI: 10.1016/j.ccell.2019.04.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  58. Dec 2021
  59. www.sciencedirect.com www.sciencedirect.com
    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
    1
    1. scibot 22 Dec 2021
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2021.110138

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    sciencedirect.com/science/article/pii/S221112472101634X
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
    1
    1. scibot 01 Dec 2021
      RRID:AB_20662659

      DOI: 10.1016/j.celrep.2021.110060

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      Curator comments: Rabbit Anti-ATM Monoclonal Antibody, Unconjugated, Clone D2E2 Cell Signaling Technology Cat# 2873

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  61. Nov 2021
  62. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation
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      DOI: 10.7554/eLife.64695

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  64. Aug 2021
  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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      DOI: 10.1002/advs.202100779

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  68. Jul 2021
  69. www.sciencedirect.com www.sciencedirect.com
    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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  70. Jun 2021
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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  72. www.sciencedirect.com www.sciencedirect.com
    Bacterial genotoxins induce T cell senescence
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  73. Apr 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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  75. Mar 2021
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    Systematic characterization of mutations altering protein degradation in human cancers
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    Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness
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    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  80. Feb 2021
  81. www.sciencedirect.com www.sciencedirect.com
    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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  82. Sep 2020
  83. academic.oup.com academic.oup.com
    Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
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      DOI: 10.1093/nar/gkaa733

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  84. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
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      DOI: 10.1158/2159-8290.CD-19-1228

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  85. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
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      DOI: 10.1016/j.celrep.2020.01.052

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  86. www.sciencedirect.com www.sciencedirect.com
    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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      DOI: 10.1016/j.celrep.2019.12.032

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  87. www.cell.com www.cell.com
    Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
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      DOI: 10.1016/j.molcel.2018.11.001

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    cell.com/molecular-cell/abstract/S1097-2765(18)30943-2
  88. Jan 2020
  89. www.sciencedirect.com www.sciencedirect.com
    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
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      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2019.06.043

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
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      DOI: 10.1016/j.celrep.2019.08.085

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  91. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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      DOI: 10.1016/j.ccell.2019.01.020

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  93. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1097276518309432
  94. Nov 2018
  95. www.sciencedirect.com www.sciencedirect.com
    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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  99. Nov 2017
  100. www.jneurosci.org www.jneurosci.org
    DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis
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