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  1. Last 7 days
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    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
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    1. scibot 02 May 2024
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  3. Apr 2024
  4. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  5. Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    sciencedirect.com/science/article/pii/S2211124724003036
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    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
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    1. scibot 16 Mar 2024
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    1. scibot 08 Mar 2024
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  9. Feb 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
  12. Jan 2024
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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      DOI: 10.1016/j.xcrm.2023.101376

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    sciencedirect.com/science/article/pii/S2666379123006055
  14. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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  16. Nov 2023
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    Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia
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    1. scibot 17 Nov 2023
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    sciencedirect.com/science/article/pii/S1873506123002337
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    ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
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    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113402

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    sciencedirect.com/science/article/pii/S2211124723014146
  19. Oct 2023
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    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
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  21. Aug 2023
  22. 52.53.155.43 52.53.155.43
    SSRN-id4513724-html.html
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      DOI: 10.2139/ssrn.4513724

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  23. Jul 2023
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    sciencedirect.com/science/article/pii/S1535610823002179
  26. Apr 2023
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    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
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    sciencedirect.com/science/article/pii/S2211124723004114
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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  29. Mar 2023
  30. link.springer.com link.springer.com
    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
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      DOI: 10.1007/s13402-023-00793-x

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    link.springer.com/article/10.1007/s13402-023-00793-x
  31. Nov 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633742/
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    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
  34. Oct 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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      DOI: 10.1128/jvi.02028-21

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  36. May 2022
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    sciencedirect.com/science/article/pii/S1097276522003938
  38. www.cell.com www.cell.com
    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
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    cell.com/cell/fulltext/S0092-8674(22)00461-5
  39. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  42. Mar 2022
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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    sciencedirect.com/science/article/pii/S2589004222001821
  44. Jan 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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      DOI: 10.3390/cancers14020326

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  47. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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      DOI: 10.1016/j.celrep.2021.110138

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    sciencedirect.com/science/article/pii/S221112472101634X
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  50. Nov 2021
  51. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation
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      DOI: 10.7554/eLife.64695

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    ncbi.nlm.nih.gov/pmc/articles/PMC8601662/
  53. Aug 2021
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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      DOI: 10.1002/advs.202100779

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    onlinelibrary.wiley.com/doi/10.1002/advs.202100779
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1523/JNEUROSCI.4213-15.2016

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    ncbi.nlm.nih.gov/pmc/articles/PMC5296783/
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      DOI: 10.1016/j.molcel.2018.11.001

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    ncbi.nlm.nih.gov/pmc/articles/PMC6344341/
  57. Jul 2021
  58. www.sciencedirect.com www.sciencedirect.com
    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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      DOI: 10.1016/j.devcel.2021.06.010

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    sciencedirect.com/science/article/pii/S1534580721005177
  59. Jun 2021
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
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    Bacterial genotoxins induce T cell senescence
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    1. scibot 09 Jun 2021
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2021.109220

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    sciencedirect.com/science/article/pii/S2211124721005714
  62. Apr 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
    1
    1. scibot 12 Apr 2021
      RRID:AB_2062659

      DOI: 10.1016/j.cell.2021.01.041

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    sciencedirect.com/science/article/pii/S0092867421000842
  64. Mar 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Systematic characterization of mutations altering protein degradation in human cancers
    1
    1. scibot 29 Mar 2021
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2021.01.020

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    sciencedirect.com/science/article/pii/S109727652100040X
  66. www.sciencedirect.com www.sciencedirect.com
    Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness
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    1. scibot 08 Mar 2021
      RRID:AB_2062659

      DOI: 10.1016/j.chembiol.2021.01.001

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    sciencedirect.com/science/article/pii/S2451945621000015
  67. www.sciencedirect.com www.sciencedirect.com
    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
    1
    1. scibot 03 Mar 2021
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2021.108808

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    sciencedirect.com/science/article/pii/S2211124721001224
  68. www.sciencedirect.com www.sciencedirect.com
    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
    1
    1. scibot 01 Mar 2021
      RRID:AB_2062659

      DOI: 10.1016/j.ccell.2020.12.010

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    sciencedirect.com/science/article/pii/S1535610820306589
  69. Feb 2021
  70. www.sciencedirect.com www.sciencedirect.com
    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    1. scibot 27 Feb 2021
      RRID:AB_2062659

      DOI: 10.1016/j.cell.2020.11.042

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    sciencedirect.com/science/article/pii/S0092867420316147
  71. Sep 2020
  72. academic.oup.com academic.oup.com
    Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
    1
    1. scibot 13 Sep 2020
      ATM

      DOI: 10.1093/nar/gkaa733

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa733/5902436
  73. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
    1
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      ATM

      DOI: 10.1158/2159-8290.CD-19-1228

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  74. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
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    1. scibot 09 Sep 2020
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2020.01.052

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    sciencedirect.com/science/article/pii/S2211124720300772
  75. www.sciencedirect.com www.sciencedirect.com
    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    1. scibot 07 Sep 2020
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2019.12.032

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    sciencedirect.com/science/article/pii/S2211124719316821
  76. www.cell.com www.cell.com
    Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
    1
    1. scibot 04 Sep 2020
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2018.11.001

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    cell.com/molecular-cell/abstract/S1097-2765(18)30943-2
  77. Jan 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
    1
    1. scibot 13 Jan 2020
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2019.06.043

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    sciencedirect.com/science/article/pii/S2211124719308162
  79. www.sciencedirect.com www.sciencedirect.com
    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2062659

      DOI: 10.1016/j.celrep.2019.08.085

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    sciencedirect.com/science/article/pii/S2211124719311477
  80. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
    1
    1. scibot 13 Jan 2020
      AB_2062659

      DOI: 10.1016/j.ccell.2019.09.004

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    sciencedirect.com/science/article/pii/S1535610819304246
  81. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
    1. scibot 13 Jan 2020
      RRID:AB_2062659

      DOI: 10.1016/j.ccell.2019.01.020

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    sciencedirect.com/science/article/pii/S1535610819300546
  82. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2062659

      DOI: 10.1016/j.molcel.2018.11.001

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    sciencedirect.com/science/article/pii/S1097276518309432
  83. Nov 2018
  84. www.sciencedirect.com www.sciencedirect.com
    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
    1
    1. scibot 05 Nov 2018
      RRID:AB_2062659

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867418310997
  85. www.sciencedirect.com www.sciencedirect.com
    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
    1
    1. scibot 05 Nov 2018
      RRID:AB_2062659

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    sciencedirect.com/science/article/pii/S1535610818302691
  86. www.sciencedirect.com www.sciencedirect.com
    The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_2062659

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518300601
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
    1
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      RRID:AB_2062659

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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  88. Nov 2017
  89. www.jneurosci.org www.jneurosci.org
    DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis
    2
    1. scibot 08 Nov 2017
      AB_2062659

      Curator: @chewbeccax

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    2. scibot 08 Nov 2017
      AB_2062659

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    jneurosci.org/content/37/4/893.long