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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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  DOI: 10.1016/j.cell.2025.12.012
  
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sciencedirect.com/science/article/pii/S0092867425014254
Sep 2025
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2025.09.04.674092v1.full-html.html

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  DOI: 10.1101/2025.09.04.674092
  
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52.53.155.43/d4c9c6086efb06675e63a3077fc191784844b6fa/2025.09.04.674092v1.full-html.html
Aug 2025
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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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1. scibot 12 Aug 2025
  
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  DOI: 10.1038/s41467-025-62379-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12335601/
Jun 2025
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Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

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  DOI: 10.1038/s41593-025-01973-8
  
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nature.com/articles/s41593-025-01973-8
May 2025
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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

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sciencedirect.com/science/article/pii/S1550413125002530
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IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

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  DOI: 10.1016/j.celrep.2025.115694
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00465-6
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ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

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  DOI: 10.1016/j.celrep.2025.115691
  
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sciencedirect.com/science/article/pii/S2211124725004620
Apr 2025
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Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis

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  DOI: 10.21203/rs.3.rs-6010379/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957193/
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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

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1. scibot 08 Apr 2025
  
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sciencedirect.com/science/article/pii/S2211124725003067
Feb 2025
52.53.155.43 52.53.155.43

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.22.614256
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Aug 2024
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Quantitative proteomics unveils known and previously unrecognized alterations in neuropathic nerves

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1. scibot 19 Aug 2024
  
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  DOI: 10.1111/jnc.16189
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16189
Jul 2024
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Aging Differentially Affects Axonal Autophagosome Formation and Maturation

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1. scibot 20 Jul 2024
  
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  DOI: 10.1080/15548627.2023.2236485
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621248/
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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.devcel.2020.07.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
Jun 2024
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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114316
  
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sciencedirect.com/science/article/pii/S2211124724006442
May 2024
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No Evidence of Sensory Neuropathy in a Traditional Mouse Model of Idiopathic Parkinson’s Disease

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1. scibot 30 May 2024
  
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  DOI: 10.3390/cells13100799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11120514/
52.53.155.43 52.53.155.43

No Evidence Of Sensory Neuropathy In A Traditional Mouse Model Of Idiopathic Parkinson’s Disease

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1. scibot 17 May 2024
  
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  DOI: 10.20944/preprints202403.0625.v1
  
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52.53.155.43/d331407b38b5ae3727f61a4bfd2545dc01b879fe/preprints202403.0625.v1-html.html
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114149
  
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sciencedirect.com/science/article/pii/S2211124724004777
Mar 2024
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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

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  DOI: 10.1016/j.molcel.2024.02.006
  
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sciencedirect.com/science/article/pii/S1097276524001254
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Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

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  DOI: 10.7554/eLife.89453
  
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2. scibot 01 Mar 2024
  
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  DOI: 10.7554/eLife.89453
  
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elifesciences.org/articles/89453
Dec 2023
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Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy

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  DOI: 10.1016/j.celrep.2023.113529
  
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sciencedirect.com/science/article/pii/S2211124723015413
Nov 2023
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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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  DOI: 10.1016/j.celrep.2023.113436
  
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sciencedirect.com/science/article/pii/S2211124723014481
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Deciphering the mechanism of action of VP343, an antileishmanial drug candidate, in Leishmania infantum

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108144
  
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sciencedirect.com/science/article/pii/S2589004223022216
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

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1. scibot 31 Oct 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10604681/
Sep 2023
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Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice

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  DOI: 10.1038/s41467-023-41502-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10505217/
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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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sciencedirect.com/science/article/pii/S2211124723010537
May 2023
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DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

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  DOI: 10.1016/j.celrep.2023.112575
  
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sciencedirect.com/science/article/pii/S2211124723005867
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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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  DOI: 10.1016/j.ccell.2023.04.016
  
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sciencedirect.com/science/article/pii/S1535610823001423
insight.jci.org insight.jci.org

Immune landscape of a genetically engineered murine model of glioma compared to human glioma by single-cell sequencing

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  DOI: 10.1172/jci.insight.148990
  
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insight.jci.org/articles/view/148990
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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  DOI: 10.1016/j.isci.2023.106375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
Dec 2022
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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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  DOI: 10.1016/j.celrep.2022.111862
  
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sciencedirect.com/science/article/pii/S2211124722017582
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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  DOI: 10.3389/fnmol.2022.1069122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9749902/
Nov 2022
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Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events and slow maturation

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  DOI: 10.1091/mbc.E22-03-0111
  
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molbiolcell.org/doi/10.1091/mbc.E22-03-0111
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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

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  DOI: 10.1016/j.neuron.2022.10.022
  
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sciencedirect.com/science/article/pii/S0896627322009552
May 2022
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p57Kip2 imposes the reserve stem cell state of gastric chief cells

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  DOI: 10.1016/j.stem.2022.04.001
  
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Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion

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Stabilin receptors clear LPS and control systemic inflammation

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A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication

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Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

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Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus

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A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication

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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

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CREG1 promotes lysosomal biogenesis and function

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Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme

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Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection

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14,15-epoxyeicosatrienoic acid alleviates pathology in a mouse model of Alzheimer’s disease

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The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

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Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

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Hemozoin produced by mammals confers heme tolerance

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Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

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A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

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ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

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  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Validated
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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
www.jneurosci.org www.jneurosci.org

The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2134500
  
  DOI: 10.1523/JNEUROSCI.2811-18.2019
  
  Resource: (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Validated
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URL

jneurosci.org/content/39/18/3376
Nov 2018
www.nature.com www.nature.com

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

1
1. scibot 05 Nov 2018
  
  in Public
  
  AB_528127
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  Originally identified as: RRID:AB_528127
  
  SciCrunch record: RRID:AB_528127
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2134500
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nature.com/articles/ncb3631
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2134500
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500
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sciencedirect.com/science/article/pii/S2211124718315250
www.sciencedirect.com www.sciencedirect.com

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2134500
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500
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sciencedirect.com/science/article/pii/S1550413118303309
onlinelibrary.wiley.com onlinelibrary.wiley.com

Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2134500
  
  Curator: @evieth
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2134500 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/full/10.1111/tra.12552
academic.oup.com academic.oup.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2134500
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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academic.oup.com/hmg/article/26/22/4352/4082708
Nov 2017
academic.oup.com academic.oup.com

Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:AB_2134500
  
  Curator: @patriciaelyse_
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Validated
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academic.oup.com/hmg/article/doi/10.1093/hmg/ddx321/4082708/Impaired-axonal-retrograde-trafficking-of-the
www.sciencedirect.com www.sciencedirect.com

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_2134500
  
  Curator: @chewbeccax
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627317304750
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

1
1. scibot 08 Nov 2017
  
  in Public
  
  anti-LAMP1
  
  Curator: @chewbeccax
  
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  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC5127638/
www.sciencedirect.com www.sciencedirect.com

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_2134500
  
  Curator: @chewbeccax
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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sciencedirect.com/science/article/pii/S0896627317300430
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_2134500
  
  Curator: @gabimpine
  
  Resource used:
  
  (DSHB Cat# 1d4b, RRID:AB_2134500)
  
  SciCrunch record: RRID:AB_2134500
  
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  RRID:AB_2134500 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC4388928/
Dec 2015
www.jneurosci.org www.jneurosci.org

Untitled document

1
1. judell 21 Dec 2015
  
  in Public
  
  AB_2134500
  
  Antibody ID: AB_2134500
  Target Antigen: Lamp1 See NCBI gene
  Vendor: DSHB
  Cat Num: 1D4B
  Proper Citation: (DSHB Cat# 1D4B, RRID:AB_2134500)
  Reference: PMID:21344404
  Clonality: monoclonal antibody
  Clone ID: None
  Host Organism: rat
  Comments: Useful for western blot mouse
  resolver lookup
  
  RRID:AB_2134500
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jneurosci.org/content/35/14/5724.long
www.jneurosci.org www.jneurosci.org

Untitled document

1
1. judell 17 Dec 2015
  
  in Public
  
  AB_2134500
  
  Antibody ID: AB_2134500
  Target Antigen: Lamp1 See NCBI gene
  Vendor: DSHB
  Cat Num: 1D4B
  Proper Citation: (DSHB Cat# 1D4B, RRID:AB_2134500)
  Reference: PMID:21344404
  Clonality: monoclonal antibody
  Clone ID: None
  Host Organism: rat
  Comments: Useful for western blot mouse
  resolver lookup
  
  RRID:AB_2134500
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jneurosci.org/content/35/14/5724.full

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