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Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade

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  DOI: 10.1038/s41418-026-01672-2
  
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nature.com/articles/s41418-026-01672-2
Nov 2025
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Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice

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1. scibot 26 Nov 2025
  
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  DOI: 10.1038/s42255-025-01402-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12638252/
Oct 2025
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Glutamate decreases oxidative stress and lipid droplet formation in astrocytes

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1. scibot 23 Oct 2025
  
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  DOI: 10.1242/jcs.263983
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12539204/
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

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1. scibot 08 Oct 2025
  
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sciencedirect.com/science/article/pii/S1550413125003894
Sep 2025
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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  DOI: 10.1016/j.molcel.2025.08.035
  
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sciencedirect.com/science/article/pii/S1097276525007415
Aug 2025
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High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis

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  DOI: 10.1016/j.celrep.2025.116207
  
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sciencedirect.com/science/article/pii/S2211124725009787
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

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  DOI: 10.1016/j.cell.2025.07.041
  
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sciencedirect.com/science/article/pii/S0092867425008633
Jun 2025
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Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

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nature.com/articles/s41418-025-01532-5
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Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00236-8
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Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure

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sciencedirect.com/science/article/pii/S2772976125001783
May 2025
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CD47-blocking antibody confers metabolic benefits against obesity

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1. scibot 19 May 2025
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00162-4
Apr 2025
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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling

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1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.015
  
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sciencedirect.com/science/article/pii/S1550413125002074
Mar 2025
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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1. scibot 23 Mar 2025
  
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  DOI: 10.1101/2025.02.17.638704
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870510/
Feb 2025
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Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice

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1. scibot 27 Feb 2025
  
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  DOI: 10.1113/JP287592
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP287592
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101941
  
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The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice

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1. scibot 07 Feb 2025
  
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  DOI: 10.1101/2024.11.26.625441
  
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52.53.155.43/0ad10a4b143da766a0796a5cae53ba79e7ffc8ca/2024.11.26.625441.full-html.html
Jan 2025
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.002
  
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sciencedirect.com/science/article/pii/S2451945625000029
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
Dec 2024
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The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle

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1. scibot 05 Dec 2024
  
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  DOI: 10.1096/fj.202401145RR
  
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faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202401145RR
Nov 2024
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Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

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1. scibot 10 Nov 2024
  
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  DOI: 10.3389/fphar.2024.1496639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11537861/
Sep 2024
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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.102
  
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Intravenous lipid emulsions designed to meet preterm infant requirements increase plasma and tissue levels of docosahexaenoic acid and arachidonic acid in mice

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Crosstalk between butyrate oxidation in colonocyte and butyrate-producing bacteria

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sciencedirect.com/science/article/pii/S2589004224020789
May 2024
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Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle

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1. scibot 24 May 2024
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP285719
Apr 2024
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Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction

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  DOI: 10.1038/s44324-024-00006-5
  
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nature.com/articles/s44324-024-00006-5
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Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation

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ncbi.nlm.nih.gov/pmc/articles/PMC10983109/
Mar 2024
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Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

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  DOI: 10.1016/j.celrep.2024.113868
  
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sciencedirect.com/science/article/pii/S2211124724001967
Dec 2023
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Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

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1. scibot 28 Dec 2023
  
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  DOI: 10.3389/fnmol.2023.1323431
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
Oct 2023
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Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine

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1. scibot 12 Oct 2023
  
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  DOI: 10.3892/ol.2023.14067
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.112790
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10528745/
Jul 2023
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Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects

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Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression

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Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission

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Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

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Histone malonylation is regulated by SIRT5 and KAT2A

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Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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A simplified and defined serum-free medium for cultivating fat across species

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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis

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The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations

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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Drosophila STING protein has a role in lipid metabolism

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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

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A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

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Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

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The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

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The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding

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Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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Theaflavin TF3 relieves hepatocyte lipid deposition through activating AMPK signaling pathway by targeting plasma kallikrein

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Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle

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Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor

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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

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Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding

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Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

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Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism

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BPS Publications

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

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Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

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BPS Publications

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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

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A Metabolic Basis for Endothelial-to-Mesenchymal Transition

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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

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Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity

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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

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