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Jul 2025
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Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression

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  DOI: 10.1016/j.celrep.2024.115183
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12180712/
Jun 2025
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Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

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nature.com/articles/s41418-025-01532-5
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Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids

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pmc.ncbi.nlm.nih.gov/articles/PMC12294511/
May 2025
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CD47-blocking antibody confers metabolic benefits against obesity

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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00162-4
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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sciencedirect.com/science/article/pii/S2211124725004991
Apr 2025
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Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

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sciencedirect.com/science/article/pii/S1550413125001160
Feb 2025
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice

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physoc.onlinelibrary.wiley.com/doi/10.1113/JP287592
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RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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sciencedirect.com/science/article/pii/S266637912500014X
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Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk

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Jan 2025
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1-s2.0-S2212877824002229-main-html.html

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52.53.155.43/ff53ca808409e557edfcd52846690258be8d728c/1-s2.0-S2212877824002229-main-html.html
Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
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Lithocholic acid phenocopies anti-ageing effects of calorie restriction

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1. scibot 21 Dec 2024
  
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faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle

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faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202401145RR
Nov 2024
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Opposing roles for AMPK in regulating distinct mitophagy pathways

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sciencedirect.com/science/article/pii/S1097276524008657
Sep 2024
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.102
  
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sciencedirect.com/science/article/pii/S2211124719302888
Aug 2024
www.pnas.org www.pnas.org

Highly specific σ<sub>2</sub>R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response

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1. scibot 13 Aug 2024
  
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  Cell Signaling #3661
  
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pnas.org/doi/10.1073/pnas.2306090120
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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.molcel.2020.12.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30900-X
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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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  ACC p-Ser79
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jul 2024
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The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

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  DOI: 10.1016/j.isci.2024.110290
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11263643/
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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  DOI: 10.1038/s41422-024-00985-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
Jun 2024
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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

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sciencedirect.com/science/article/pii/S1550413124001864
May 2024
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

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sciencedirect.com/science/article/pii/S1097276524003241
Apr 2024
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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  DOI: 10.1093/narcan/zcae018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
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AMPK activation modulates IL-36-induced inflammatory responses by regulating IκBζ expression in the skin

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  DOI: 10.1111/bph.16354
  
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  DOI: 10.1111/bph.16354
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16354
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Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction

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  DOI: 10.1038/s44324-024-00006-5
  
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nature.com/articles/s44324-024-00006-5
Mar 2024
www.biorxiv.org www.biorxiv.org

Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis

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  DOI: 10.1101/2024.02.29.582877
  
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biorxiv.org/content/10.1101/2024.02.29.582877v1
Feb 2024
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Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice

2
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  DOI: 10.1101/2023.09.01.555935
  
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  DOI: 10.1101/2023.09.01.555935
  
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52.53.155.43/fd6bbeebd50ae2c0912f6e8604e8bc905b0c2518/2023.09.01.555935v1.full-html.html
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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC10897550/
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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

3
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  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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biorxiv.org/content/10.1101/2023.12.05.570182v1
Jan 2024
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CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue

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1. scibot 26 Jan 2024
  
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  DOI: 10.3389/fimmu.2023.1308456
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10803534/
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WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

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  DOI: 10.1158/2767-9764.CRC-23-0275
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10793200/
Dec 2023
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Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner

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1. scibot 13 Dec 2023
  
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  DOI: 10.1038/s41467-023-44039-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10710518/
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MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle

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Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

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Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

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Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity

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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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Aug 2023
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LINC00116-Encoded Microprotein Mitoregulin Regulates Fatty Acid Metabolism at the Mitochondrial Outer Membrane

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Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner

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Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects

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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

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Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis

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Neuronal blockade of thyroid hormone signaling increases sensitivity to diet-induced obesity in adult male mice

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Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD

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Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

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Histone malonylation is regulated by SIRT5 and KAT2A

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Feb 2023
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Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis

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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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Protein signaling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle

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Manipulating bovine granulosa cell energy metabolism limits inflammation

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Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

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May 2022
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Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

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Mar 2022
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Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

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Feb 2022
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Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy

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Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin

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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function

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Jan 2022
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The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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japplphysiol.00107.2021-html.html

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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

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A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

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Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

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AMPK ACTIVATION AMELIORATES KIDNEY VASCULAR DYSFUNCTION, OXIDATIVE STRESS AND INFLAMMATION IN OBESITY

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Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner

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Untitled document

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Untitled document

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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

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  Rabbit polyclonal Anti-pACC/TotACC
  
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

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Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

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Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis

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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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PKA and AMPK Signaling Pathways Differentially Regulate Luteal Steroidogenesis

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AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

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ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

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Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

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AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

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Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

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JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding

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Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice

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Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation

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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

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Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism

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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport

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CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

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The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth

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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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BPS Publications

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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

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Untitled document

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Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

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The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling

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Untitled document

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Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

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Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis

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Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4

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ERRATUM FOR “α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet–Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling”

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α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet–Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling

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academic.oup.com/endo/article/159/2/931/4764022
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PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs

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sciencedirect.com/science/article/pii/S1550413117305570
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Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice

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academic.oup.com/endo/article/158/10/3090/4082873/Antibody-Mediated-Targeting-of-the-FGFR1c-Isoform
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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

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ncbi.nlm.nih.gov/pmc/articles/PMC5501726/table/undtbl1/
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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

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1. scibot 08 Nov 2017
  
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  AB_330337
  
  Curator: @chewbeccax
  
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3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice

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1. scibot 08 Nov 2017
  
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  AB_330337
  
  Curator: @bandrow
  
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academic.oup.com/endo/article/158/6/1977/3078999/3-Iodothyronamine-Induces-Tail-Vasodilation
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S2405471216304082
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

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1. scibot 08 Nov 2017
  
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  AB_330337
  
  Curator: @gabimpine
  
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sciencedirect.com/science/article/pii/S1550413117302139
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

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1. scibot 08 Nov 2017
  
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  3661
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4931344/
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SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

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1. scibot 08 Nov 2017
  
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  AB_330337
  
  Curator: @gabimpine
  
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elifesciences.org/articles/18206
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Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

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1. scibot 08 Nov 2017
  
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  AB_330337
  
  Curator: @jcabotaj
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4502912/

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