58 Matching Annotations
  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A TBK1-independent primordial function of STING in lysosomal biogenesis
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.molcel.2024.08.026

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    sciencedirect.com/science/article/pii/S1097276524007032
  3. www.sciencedirect.com www.sciencedirect.com
    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
    1
    1. scibot 25 Sep 2024
      AB_2773013

      DOI: 10.1016/j.cell.2019.05.036

      Resource: (Cell Signaling Technology Cat# 10327, RRID:AB_2797719)

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      Curator comments: Phospho-IRF-3 (Ser396) (D6O1M) Rabbit MAb (Alexa Fluor®647 Conjugate) Antibody Cell Signaling Technology Cat# 10327

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    sciencedirect.com/science/article/pii/S0092867419305641
  4. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
    1
    1. scibot 25 Sep 2024
      RRID:AB_823547

      DOI: 10.1186/s12915-018-0507-6

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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0507-6
  5. www.sciencedirect.com www.sciencedirect.com
    Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity
    1
    1. scibot 10 Sep 2024
      AB_2773013

      DOI: 10.1016/j.molcel.2024.08.014

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    sciencedirect.com/science/article/pii/S1097276524006683
  6. Jul 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
    1
    1. scibot 27 Jul 2024
      RRID:AB_2773013

      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
  8. www.sciencedirect.com www.sciencedirect.com
    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.medj.2024.06.002

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    sciencedirect.com/science/article/pii/S2666634024002484
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
    1
    1. scibot 14 Jul 2024
      RRID:AB_2773013

      DOI: 10.1016/j.isci.2024.110144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
  10. www.cell.com www.cell.com
    GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
    1
    1. scibot 11 Jul 2024
      RRID:AB_2773013

      DOI: 10.1016/j.devcel.2024.06.007

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    cell.com/developmental-cell/abstract/S1534-5807(24)00385-X
  11. Jun 2024
  12. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
    1
    1. scibot 21 Jun 2024
      RRID:AB_2773013

      DOI: 10.1016/j.cell.2024.05.031

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    sciencedirect.com/science/article/pii/S0092867424005762
  13. Apr 2024
  14. www.sciencedirect.com www.sciencedirect.com
    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
    1
    1. scibot 11 Apr 2024
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2024.114088

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    sciencedirect.com/science/article/pii/S2211124724004169
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment
    1
    1. scibot 03 Apr 2024
      AB_2773013

      DOI: 10.1158/0008-5472.CAN-23-0046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
  16. Mar 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
    1
    1. scibot 23 Mar 2024
      RRID:AB_2773013

      DOI: 10.7554/eLife.88122

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation
    1
    1. scibot 17 Mar 2024
      RRID:AB_2773013

      DOI: 10.1158/0008-5472.CAN-23-1237

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    ncbi.nlm.nih.gov/pmc/articles/PMC10940857/
  19. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
    1
    1. scibot 15 Mar 2024
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2024.113945

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    sciencedirect.com/science/article/pii/S2211124724002730
  20. Nov 2023
  21. www.sciencedirect.com www.sciencedirect.com
    AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms
    1
    1. scibot 28 Nov 2023
      RRID:AB_2773013

      DOI: 10.1016/j.chembiol.2023.10.008

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    sciencedirect.com/science/article/abs/pii/S2451945623003690
  22. Oct 2023
  23. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
    1
    1. scibot 20 Oct 2023
      AB_2773013

      DOI: 10.1101/2023.08.11.553045

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    52.53.155.43/b51af3efb3ab194b2ea96b77566b6b4cbbb36c40/2023.08.11.553045v1.full-html.html
  24. www.sciencedirect.com www.sciencedirect.com
    Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells
    1
    1. scibot 13 Oct 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.113213

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    sciencedirect.com/science/article/pii/S2211124723012251
  25. Jul 2023
  26. www.sciencedirect.com www.sciencedirect.com
    STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
    1
    1. scibot 29 Jul 2023
      RRID:AB_2773013

      DOI: 10.1016/j.isci.2023.107376

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    sciencedirect.com/science/article/pii/S2589004223014530
  27. www.sciencedirect.com www.sciencedirect.com
    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
    1
    1. scibot 27 Jul 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.112852

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    sciencedirect.com/science/article/pii/S221112472300863X
  28. Jun 2023
  29. www.sciencedirect.com www.sciencedirect.com
    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
    1
    1. scibot 21 Jun 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.112655

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    sciencedirect.com/science/article/pii/S2211124723006666
  30. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
    1. scibot 02 Jun 2023
      RRID:AB_2773013

      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
  31. May 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
    1
    1. scibot 26 May 2023
      RRID:AB_2773013

      DOI: 10.1016/j.ccell.2023.04.018

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    sciencedirect.com/science/article/pii/S1535610823001629
  33. www.pnas.org www.pnas.org
    A genome-wide optical pooled screen reveals regulators of cellular antiviral responses
    1
    1. scibot 18 May 2023
      RRID:AB_2773013

      DOI: 10.1073/pnas.2210623120

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    pnas.org/doi/abs/10.1073/pnas.2210623120
  34. Apr 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
    1
    1. scibot 26 Apr 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.112442

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    sciencedirect.com/science/article/pii/S2211124723004539
  36. Mar 2023
  37. www.sciencedirect.com www.sciencedirect.com
    4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
    1
    1. scibot 02 Mar 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.112145

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    sciencedirect.com/science/article/pii/S2211124723001560
  38. Jan 2023
  39. www.sciencedirect.com www.sciencedirect.com
    A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3
    1
    1. scibot 25 Jan 2023
      RRID:AB_2773013

      DOI: 10.1016/j.isci.2023.105935

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    sciencedirect.com/science/article/pii/S2589004223000123
  40. www.sciencedirect.com www.sciencedirect.com
    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
    1
    1. scibot 21 Jan 2023
      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2023.112002

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    sciencedirect.com/science/article/pii/S221112472300013X
  41. www.sciencedirect.com www.sciencedirect.com
    Resurrection of endogenous retroviruses during aging reinforces senescence
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    1. scibot 07 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.017

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    sciencedirect.com/science/article/pii/S0092867422015306
  42. Oct 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
    1
    1. scibot 05 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111434

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    sciencedirect.com/science/article/pii/S221112472201275X
  44. Sep 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
    1
    1. scibot 30 Sep 2022
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      DOI: 10.1016/j.isci.2022.105145

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
    1
    1. scibot 09 Sep 2022
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      DOI: 10.1002/jcla.24631

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    onlinelibrary.wiley.com/doi/10.1002/jcla.24631
  47. Aug 2022
  48. www.sciencedirect.com www.sciencedirect.com
    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
    1
    1. scibot 06 Aug 2022
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      DOI: 10.1016/j.immuni.2022.06.022

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    sciencedirect.com/science/article/pii/S1074761322002953
  49. Jul 2022
  50. www.sciencedirect.com www.sciencedirect.com
    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
    1
    1. scibot 08 Jul 2022
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      DOI: 10.1016/j.isci.2022.104607

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    sciencedirect.com/science/article/pii/S2589004222008793
  51. May 2022
  52. www.sciencedirect.com www.sciencedirect.com
    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    1. scibot 26 May 2022
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      DOI: 10.1016/j.celrep.2022.110838

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    sciencedirect.com/science/article/pii/S2211124722006118
  53. Feb 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
    1
    1. scibot 04 Feb 2022
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      DOI: 10.1016/j.ccell.2022.01.003

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    sciencedirect.com/science/article/pii/S1535610822000058
  55. Jan 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
    1
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      DOI: 10.1016/j.celrep.2022.110302

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    sciencedirect.com/science/article/pii/S2211124722000146
  57. Nov 2021
  58. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 23 Nov 2021
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      DOI: 10.1111/bph.15673

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15673
  59. Aug 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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      DOI: 10.1016/j.celrep.2021.109537

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    sciencedirect.com/science/article/pii/S2211124721009712
  61. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    1. scibot 16 Aug 2021
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      DOI: 10.1158/0008-5472.CAN-20-3738

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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
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  64. Jun 2021
  65. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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  66. May 2021
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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      DOI: 10.1016/j.stem.2020.06.022

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    sciencedirect.com/science/article/pii/S1934590920302897
  69. Apr 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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  71. Mar 2021
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    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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    ER-directed TREX1 limits cGAS activation at micronuclei
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  74. Feb 2021
  75. www.sciencedirect.com www.sciencedirect.com
    Evasion of type-I interferon by SARS-CoV-2
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    sciencedirect.com/science/article/pii/S2211124720312237
  76. Oct 2020
  77. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Evasion of type-I interferon by SARS-CoV-2
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  79. Sep 2020
  80. www.sciencedirect.com www.sciencedirect.com
    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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    SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
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      DOI: 10.1016/j.celrep.2020.02.112

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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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      DOI: 10.1016/j.immuni.2020.02.002

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  84. Jan 2020
  85. www.sciencedirect.com www.sciencedirect.com
    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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      DOI: 10.1016/j.molcel.2019.07.029

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    sciencedirect.com/science/article/pii/S1097276519305842
  86. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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      DOI: 10.1016/j.celrep.2019.09.050

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    cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
  87. www.sciencedirect.com www.sciencedirect.com
    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      RRID:AB_2773013

      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
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    Untitled document
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      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2019.01.030

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    sciencedirect.com/science/article/pii/S2211124719300397