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Jul 2026
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Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117708
  
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
Jun 2026
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The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma

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  DOI: 10.1016/j.isci.2026.116500
  
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Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117580
  
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Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple-Negative Breast Cancer to PD-1 Blockade

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  DOI: 10.1002/advs.202521541
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521541
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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
May 2026
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STING signaling in vestibular macrophages underlies Ménière’s disease pathogenesis

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1. scibot 27 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13200447/
Apr 2026
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ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing

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1. scibot 17 Apr 2026
  
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  DOI: 10.64898/2026.04.11.717899
  
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biorxiv.org/content/10.64898/2026.04.11.717899v1
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Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma

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HSPA2 modulates antiviral immunity by inhibiting TBK1 activation

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1. scibot 07 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117222
  
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Mar 2026
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Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102714
  
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Feb 2026
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The Role of STING-Mediated Activation of the Integrated Stress Response in Inflammation-Induced Depletion of Ovarian Reserve

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1. scibot 27 Feb 2026
  
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  DOI: 10.1096/fj.202502370RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502370RR
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Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis

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1. scibot 12 Feb 2026
  
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  DOI: 10.1152/ajpheart.00589.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12889003/
Jan 2026
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Cysteine allostery and autoinhibition govern human STING oligomer functionality

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1. scibot 22 Jan 2026
  
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  DOI: 10.1038/s41589-025-01951-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12810159/
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lucero-et-al-2026-cardiomyocyte--arrestins-mediate-inflammation-and-cgas-sting-activation-in-cvb3-viral-myocarditis-html.html

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1. scibot 10 Jan 2026
  
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  DOI: 10.6084/m9.figshare.30598013
  
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54.241.53.176/230152961d72a3d5781220ef3dcdb60ea10cf9d0/lucero-et-al-2026-cardiomyocyte--arrestins-mediate-inflammation-and-cgas-sting-activation-in-cvb3-viral-myocarditis-html.html
Nov 2025
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Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116581
  
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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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1. scibot 18 Nov 2025
  
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  DOI: 10.1186/s13046-025-03566-6
  
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UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance

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1. scibot 18 Nov 2025
  
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ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation

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  DOI: 10.1016/j.celrep.2025.116547
  
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Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

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Oct 2025
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Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity

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  DOI: 10.1016/j.celrep.2025.116462
  
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Sep 2025
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Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization

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  DOI: 10.1016/j.celrep.2025.116350
  
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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Aug 2025
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IRE1α-XBP1s axis is required for BCG-induced trained immunity against viral infection by inhibiting AHR signaling

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1. scibot 30 Aug 2025
  
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  DOI: 10.1101/2025.08.21.671435
  
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biorxiv.org/content/10.1101/2025.08.21.671435v1
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TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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jeccr.biomedcentral.com/articles/10.1186/s13046-025-03513-5
Jun 2025
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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
May 2025
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GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.033
  
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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Apr 2025
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Mar 2025
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ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

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  DOI: 10.7554/eLife.101973
  
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.014
  
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Feb 2025
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Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.21.614248
  
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Jan 2025
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

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  DOI: 10.1016/j.cmet.2024.11.014
  
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Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

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Dec 2024
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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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  DOI: 10.1016/j.molcel.2024.08.026
  
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

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InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity

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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

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Jul 2024
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development

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Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment

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Mar 2024
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Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

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  DOI: 10.7554/eLife.88122
  
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A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation

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Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation

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  DOI: 10.1016/j.celrep.2024.113945
  
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AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

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  DOI: 10.1016/j.chembiol.2023.10.008
  
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Oct 2023
52.53.155.43 52.53.155.43

Blocking oligomerization is the most viable strategy to inhibit STING

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  DOI: 10.1101/2023.08.11.553045
  
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Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells

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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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Jun 2023
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A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

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  DOI: 10.1073/pnas.2210623120
  
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Apr 2023
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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Mar 2023
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Resurrection of endogenous retroviruses during aging reinforces senescence

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Oct 2022
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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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Sep 2022
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cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

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Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

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  DOI: 10.1002/jcla.24631
  
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Aug 2022
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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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Jul 2022
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LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination

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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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BPS Publications

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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

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SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

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ER-directed TREX1 limits cGAS activation at micronuclei

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Evasion of type-I interferon by SARS-CoV-2

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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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Evasion of type-I interferon by SARS-CoV-2

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs

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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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Untitled document

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