168 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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    1. scibot 09 Oct 2024
      AB_823547

      DOI: 10.1016/j.immuni.2024.09.004

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    sciencedirect.com/science/article/pii/S1074761324004485
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
    1
    1. scibot 09 Oct 2024
      AB_823547

      DOI: 10.1016/j.cell.2024.09.024

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    sciencedirect.com/science/article/pii/S0092867424010729
  4. Sep 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
    1
    1. scibot 26 Sep 2024
      RRID:AB_823547

      DOI: 10.1016/j.isci.2024.110693

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
  6. www.sciencedirect.com www.sciencedirect.com
    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
    1
    1. scibot 25 Sep 2024
      RRID:AB_823547

      DOI: 10.1016/j.chom.2019.02.013

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    sciencedirect.com/science/article/pii/S193131281930109X
  7. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
    1
    1. scibot 25 Sep 2024
      RRID:AB_823547

      DOI: 10.1186/s12915-018-0507-6

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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0507-6
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    E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS
    1
    1. scibot 04 Sep 2024
      AB_823547

      DOI: 10.1016/j.celrep.2024.114687

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    sciencedirect.com/science/article/pii/S2211124724010386
  9. Aug 2024
  10. www.sciencedirect.com www.sciencedirect.com
    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
    1
    1. scibot 20 Aug 2024
      AB_823547

      DOI: 10.1016/j.celrep.2024.114608

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    sciencedirect.com/science/article/pii/S2211124724009586
  11. www.science.org www.science.org
    SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways
    1
    1. scibot 02 Aug 2024
      4947S

      DOI: 10.1126/scisignal.abc7611

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    science.org/doi/10.1126/scisignal.abc7611
  12. Jul 2024
  13. www.sciencedirect.com www.sciencedirect.com
    A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1
    1
    1. scibot 31 Jul 2024
      AB_823547

      DOI: 10.1016/j.chom.2024.07.003

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    sciencedirect.com/science/article/pii/S1931312824002622
  14. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
    1
    1. scibot 24 Jul 2024
      AB_823547

      DOI: 10.1016/j.molcel.2024.06.001

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    sciencedirect.com/science/article/pii/S1097276524004799
  15. www.sciencedirect.com www.sciencedirect.com
    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
    2
    1. scibot 23 Jul 2024
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      DOI: 10.1016/j.molcel.2024.05.030

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    2. scibot 23 Jul 2024
      AB_823547

      DOI: 10.1016/j.molcel.2024.05.030

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    sciencedirect.com/science/article/pii/S1097276524004775
  16. www.cell.com www.cell.com
    Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver
    1
    1. scibot 19 Jul 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.114400

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    cell.com/cell-reports/abstract/S2211-1247(24)00728-9
  17. www.sciencedirect.com www.sciencedirect.com
    RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
    1
    1. scibot 17 Jul 2024
      AB_823547

      DOI: 10.1016/j.molcel.2024.06.023

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    sciencedirect.com/science/article/pii/S1097276524005306
  18. Jun 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response
    1
    1. scibot 04 Jun 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.114287

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    sciencedirect.com/science/article/pii/S2211124724006156
  20. May 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
    1
    1. scibot 23 May 2024
      RRID:AB_823547

      DOI: 10.1016/j.redox.2024.103202

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    sciencedirect.com/science/article/pii/S2213231724001800
  22. Apr 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
    1
    1. scibot 26 Apr 2024
      RRID:AB_823547

      DOI: 10.1016/j.ccell.2024.04.004

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    sciencedirect.com/science/article/pii/S1535610824001284
  24. www.sciencedirect.com www.sciencedirect.com
    Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
    1
    1. scibot 25 Apr 2024
      RRID:AB_823547

      DOI: 10.1016/j.medj.2024.03.018

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    sciencedirect.com/science/article/pii/S2666634024001302
  25. www.sciencedirect.com www.sciencedirect.com
    ISGylation by HERCs facilitates STING activation
    1
    1. scibot 23 Apr 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.114135

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    sciencedirect.com/science/article/pii/S2211124724004637
  26. www.sciencedirect.com www.sciencedirect.com
    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
    1
    1. scibot 19 Apr 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.114114

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    sciencedirect.com/science/article/pii/S221112472400442X
  27. Mar 2024
  28. www.sciencedirect.com www.sciencedirect.com
    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
    1
    1. scibot 12 Mar 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.113788

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    sciencedirect.com/science/article/pii/S2211124724001165
  29. www.sciencedirect.com www.sciencedirect.com
    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
    2
    1. scibot 01 Mar 2024
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.113870

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      RRID:AB_823547

      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  30. Feb 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
    1
    1. scibot 29 Feb 2024
      RRID:AB_823547

      DOI: 10.1016/j.immuni.2024.02.002

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    sciencedirect.com/science/article/pii/S1074761324000773
  32. aacrjournals.org aacrjournals.org
    RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion
    2
    1. scibot 23 Feb 2024
      RRID:AB_823547

      DOI: 10.1158/0008-5472.CAN-23-2049

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      RRID:AB_823547

      DOI: 10.1158/0008-5472.CAN-23-2049

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    aacrjournals.org/cancerres/article/84/3/405/733849/RNA-Methyltransferase-FTSJ3-Regulates-the-Type-I
  33. Jan 2024
  34. www.sciencedirect.com www.sciencedirect.com
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 19 Jan 2024
      RRID:AB_823547

      DOI: 10.1016/j.isci.2024.108808

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    sciencedirect.com/science/article/pii/S2589004224000294
  35. Dec 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro
    1
    1. scibot 21 Dec 2023
      RRID:AB_823547

      DOI: 10.1016/j.isci.2023.108620

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    sciencedirect.com/science/article/pii/S2589004223026974
  37. Nov 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
    1
    1. scibot 03 Nov 2023
      RRID:AB_823547

      DOI: 10.1016/j.celrep.2023.113358

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    sciencedirect.com/science/article/pii/S2211124723013700
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
    1
    1. scibot 02 Nov 2023
      RRID:AB_823547

      DOI: 10.1016/j.immuni.2023.09.012

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    sciencedirect.com/science/article/abs/pii/S107476132300417X
  40. www.sciencedirect.com www.sciencedirect.com
    Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products
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    1. scibot 02 Nov 2023
      RRID:AB_823547

      DOI: 10.1016/j.abb.2023.109808

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    sciencedirect.com/science/article/abs/pii/S0003986123003077
  41. Oct 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  43. www.embopress.org www.embopress.org
    Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children
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    1. scibot 13 Oct 2023
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      DOI: 10.15252/embr.202357912

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    embopress.org/doi/full/10.15252/embr.202357912
  44. Sep 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
  46. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
    1
    1. scibot 07 Sep 2023
      RRID:AB_823547

      DOI: 10.1016/j.isci.2023.107705

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    sciencedirect.com/science/article/pii/S2589004223017820
  47. Aug 2023
  48. www.sciencedirect.com www.sciencedirect.com
    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
    1
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      RRID:AB_823547

      DOI: 10.1016/j.celrep.2023.113040

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    sciencedirect.com/science/article/pii/S2211124723010513
  49. Jul 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 04 Jul 2023
      RRID:AB_823547

      DOI: 10.1101/2023.06.03.543579

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    ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
  51. Jun 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107090

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    sciencedirect.com/science/article/pii/S2589004223011677
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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    1. scibot 03 Jun 2023
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      DOI: 10.1158/1078-0432.CCR-22-3836

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    ncbi.nlm.nih.gov/pmc/articles/PMC10233356/
  54. www.sciencedirect.com www.sciencedirect.com
    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
    1
    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112586

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    sciencedirect.com/science/article/pii/S2211124723005971
  55. May 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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  58. Apr 2023
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    C9ORF72 suppresses JAK-STAT mediated inflammation
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    Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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  63. Mar 2023
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    Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
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    ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING
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    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
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  69. Feb 2023
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    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
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  71. Jan 2023
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    Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response
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  73. Dec 2022
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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    Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade
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    Glycolaldehyde-derived advanced glycation end products suppress STING/TBK1/IRF3 signaling via CD36
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    Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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    Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation
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  95. Jun 2022
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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  101. May 2022
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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  107. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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  110. Mar 2022
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  113. Jan 2022
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  122. Sep 2021
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    A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  133. Jul 2021
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation
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  152. Mar 2021
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  154. Feb 2021
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  158. Dec 2020
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    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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  160. Sep 2020
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    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
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    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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    Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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  169. jvi.asm.org jvi.asm.org
    Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling
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  170. Jan 2020
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
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    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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    Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
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    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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  186. Nov 2018
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    Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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    The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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    An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
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    Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication
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    Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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    Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
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    Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Dampened STING-Dependent Interferon Activation in Bats
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    Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
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    The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling
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  204. Nov 2017
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    Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
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    SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
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  207. elifesciences.org elifesciences.org
    Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
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  208. www.sciencedirect.com www.sciencedirect.com
    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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  209. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
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  210. europepmc.org europepmc.org
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  212. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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  213. www.cell.com www.cell.com
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  214. www.sciencedirect.com www.sciencedirect.com
    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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