156 Matching Annotations
  1. Last 7 days
  2. www.cell.com www.cell.com
    Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver
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    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114400

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    cell.com/cell-reports/abstract/S2211-1247(24)00728-9
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    RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
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    sciencedirect.com/science/article/pii/S1097276524005306
  4. Jun 2024
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    Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response
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    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114287

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    sciencedirect.com/science/article/pii/S2211124724006156
  6. May 2024
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    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
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    1. scibot 23 May 2024
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      DOI: 10.1016/j.redox.2024.103202

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    sciencedirect.com/science/article/pii/S2213231724001800
  8. Apr 2024
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    1. scibot 26 Apr 2024
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      DOI: 10.1016/j.ccell.2024.04.004

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    sciencedirect.com/science/article/pii/S1535610824001284
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    Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
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    1. scibot 25 Apr 2024
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      DOI: 10.1016/j.medj.2024.03.018

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    sciencedirect.com/science/article/pii/S2666634024001302
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    ISGylation by HERCs facilitates STING activation
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    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114135

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    sciencedirect.com/science/article/pii/S2211124724004637
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114114

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    sciencedirect.com/science/article/pii/S221112472400442X
  13. Mar 2024
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    1. scibot 12 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724001165
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  16. Feb 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.immuni.2024.02.002

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    sciencedirect.com/science/article/pii/S1074761324000773
  18. aacrjournals.org aacrjournals.org
    RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion
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    1. scibot 23 Feb 2024
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      DOI: 10.1158/0008-5472.CAN-23-2049

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      DOI: 10.1158/0008-5472.CAN-23-2049

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    aacrjournals.org/cancerres/article/84/3/405/733849/RNA-Methyltransferase-FTSJ3-Regulates-the-Type-I
  19. Jan 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.isci.2024.108808

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    sciencedirect.com/science/article/pii/S2589004224000294
  21. Dec 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro
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    1. scibot 21 Dec 2023
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      DOI: 10.1016/j.isci.2023.108620

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    sciencedirect.com/science/article/pii/S2589004223026974
  23. Nov 2023
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    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113358

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    sciencedirect.com/science/article/pii/S2211124723013700
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.immuni.2023.09.012

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    sciencedirect.com/science/article/abs/pii/S107476132300417X
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    Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.abb.2023.109808

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    sciencedirect.com/science/article/abs/pii/S0003986123003077
  27. Oct 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  29. www.embopress.org www.embopress.org
    Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children
    1
    1. scibot 13 Oct 2023
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      DOI: 10.15252/embr.202357912

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    embopress.org/doi/full/10.15252/embr.202357912
  30. Sep 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
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    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.isci.2023.107705

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    sciencedirect.com/science/article/pii/S2589004223017820
  33. Aug 2023
  34. www.sciencedirect.com www.sciencedirect.com
    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
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    1. scibot 25 Aug 2023
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      DOI: 10.1016/j.celrep.2023.113040

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    sciencedirect.com/science/article/pii/S2211124723010513
  35. Jul 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 04 Jul 2023
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      DOI: 10.1101/2023.06.03.543579

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    ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
  37. Jun 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107090

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    sciencedirect.com/science/article/pii/S2589004223011677
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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    1. scibot 03 Jun 2023
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      DOI: 10.1158/1078-0432.CCR-22-3836

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    ncbi.nlm.nih.gov/pmc/articles/PMC10233356/
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112586

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    sciencedirect.com/science/article/pii/S2211124723005971
  41. May 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    1. scibot 18 May 2023
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      DOI: 10.1016/j.isci.2023.106758

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    sciencedirect.com/science/article/pii/S2589004223008350
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    1. scibot 12 May 2023
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      DOI: 10.1016/j.celrep.2023.112508

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    sciencedirect.com/science/article/pii/S2211124723005193
  44. Apr 2023
  45. www.sciencedirect.com www.sciencedirect.com
    C9ORF72 suppresses JAK-STAT mediated inflammation
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      DOI: 10.1016/j.isci.2023.106579

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    sciencedirect.com/science/article/pii/S2589004223006569
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    Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
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      DOI: 10.1016/j.isci.2023.106613

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    sciencedirect.com/science/article/pii/S2589004223006909
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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      DOI: 10.1016/j.devcel.2023.03.015

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    sciencedirect.com/science/article/pii/S1534580723001314
  48. www.sciencedirect.com www.sciencedirect.com
    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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      DOI: 10.1016/j.celrep.2023.112341

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    sciencedirect.com/science/article/pii/S2211124723003522
  49. Mar 2023
  50. europepmc.org europepmc.org
    Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
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      DOI: 10.1016/j.celrep.2023.112303

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    europepmc.org/article/med/36952341
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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      DOI: 10.1016/j.celrep.2023.112309

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    sciencedirect.com/science/article/pii/S2211124723003200
  52. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
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      DOI: 10.1016/j.celrep.2023.112275

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    europepmc.org/article/med/36943864
  53. www.sciencedirect.com www.sciencedirect.com
    ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING
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      DOI: 10.1016/j.immuni.2023.02.004

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    sciencedirect.com/science/article/pii/S107476132300078X
  54. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
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      DOI: 10.1016/j.celrep.2023.112185

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    sciencedirect.com/science/article/pii/S2211124723001961
  55. Feb 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
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      DOI: 10.1016/j.immuni.2023.01.001

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    sciencedirect.com/science/article/pii/S1074761323000110
  57. Jan 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response
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  59. Dec 2022
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
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  65. Nov 2022
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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  67. Oct 2022
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    Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade
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    Glycolaldehyde-derived advanced glycation end products suppress STING/TBK1/IRF3 signaling via CD36
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    Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
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  71. Sep 2022
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    Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
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  73. Aug 2022
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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  79. Jul 2022
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    Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation
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  81. Jun 2022
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    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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  87. May 2022
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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  93. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site
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  96. Mar 2022
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  99. Jan 2022
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  101. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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  103. Nov 2021
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    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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  105. Oct 2021
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    ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
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    Differential effects of viral nucleic acid sensor signaling pathways on testicular Sertoli and Leydig cells
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  108. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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    A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP
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  112. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  119. Jul 2021
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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  126. Jun 2021
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    Translation stress and collided ribosomes are co-activators of cGAS
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  129. May 2021
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation
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  135. Apr 2021
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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  138. Mar 2021
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  144. Dec 2020
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    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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  146. Sep 2020
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    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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    Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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    Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling
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  156. Jan 2020
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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    MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
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    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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    The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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    An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
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    Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication
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    Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
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    The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling
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    Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
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    Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
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    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
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    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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