186 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    1. scibot 02 Oct 2024
      AB_331679

      DOI: 10.1016/j.xcrm.2024.101752

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    sciencedirect.com/science/article/pii/S2666379124004828
  3. Sep 2024
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy
    1
    1. scibot 27 Sep 2024
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      DOI: 10.1002/glia.24612

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    onlinelibrary.wiley.com/doi/10.1002/glia.24612
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    1. scibot 26 Sep 2024
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      DOI: 10.1038/s44319-024-00217-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
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    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    1. scibot 25 Sep 2024
      RRID:AB_331679

      DOI: 10.14814/phy2.70044

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    ncbi.nlm.nih.gov/pmc/articles/PMC11410559/
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    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114606

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    ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
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    “β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease”
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.isci.2024.110773

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    sciencedirect.com/science/article/pii/S2589004224019989
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
    1
    1. scibot 25 Sep 2024
      RRID:AB_916156

      DOI: 10.1016/j.celrep.2021.108796

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    sciencedirect.com/science/article/pii/S2211124721001108
  10. Aug 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1038/s41598-024-69749-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11319469/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 21 Aug 2024
      RRID:AB_331679

      DOI: 10.1126/science.adk0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  13. Jul 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
    1
    1. scibot 31 Jul 2024
      RRID:AB_331679

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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
  15. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 18 Jul 2024
      RRID:AB_331679

      DOI: 10.1126/science.adk0775

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  16. Jun 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
    1. scibot 03 Jun 2024
      RRID:AB_331679

      DOI: 10.1016/j.isci.2024.109983

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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  18. May 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.immuni.2024.04.024

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    sciencedirect.com/science/article/pii/S1074761324002292
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hypo-responsiveness
    1
    1. scibot 15 May 2024
      RRID:AB_331679

      DOI: 10.1016/j.isci.2024.109767

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    ncbi.nlm.nih.gov/pmc/articles/PMC11088342/
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
    1
    1. scibot 10 May 2024
      RRID:AB_331679

      DOI: 10.1016/j.xcrm.2024.101552

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    sciencedirect.com/science/article/pii/S2666379124002441
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
    1
    1. scibot 03 May 2024
      RRID:AB_331679

      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  23. Apr 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia
    2
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      DOI: 10.1016/j.ccell.2024.03.003

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    2. scibot 09 Apr 2024
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      DOI: 10.1016/j.ccell.2024.03.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC11008188/
  25. www.sciencedirect.com www.sciencedirect.com
    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
    1
    1. scibot 05 Apr 2024
      RRID:AB_331679

      DOI: 10.1016/j.stem.2024.03.003

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    sciencedirect.com/science/article/pii/S1934590924000845
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sexual Dimorphism of Circadian Liver Transcriptome.
    1
    1. scibot 03 Apr 2024
      RRID:AB_331679

      DOI: 10.1016/j.isci.2024.109483

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973666/
  27. Feb 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
    1
    1. scibot 27 Feb 2024
      Cell Signaling Technology#2211

      DOI: 10.1016/j.isci.2024.109121

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    sciencedirect.com/science/article/pii/S2589004224003420
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
    1
    1. scibot 03 Feb 2024
      RRID:AB_21

      DOI: 10.1016/j.isci.2024.108857

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830855/
  30. Jan 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
    1
    1. scibot 05 Jan 2024
      RRID:AB_331679

      DOI: 10.1158/1535-7163.MCT-23-0026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
    1
    1. scibot 15 Dec 2023
      RRID:AB_331679

      DOI: 10.1016/j.nbd.2023.106370

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    sciencedirect.com/science/article/pii/S0969996123003868
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
    1
    1. scibot 02 Dec 2023
      RRID:AB_331679

      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
    1
    1. scibot 02 Dec 2023
      RRID:AB_331679

      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
  36. Nov 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
    1
    1. scibot 28 Nov 2023
      RRID:AB_331679

      DOI: 10.1016/j.molcel.2023.10.017

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    sciencedirect.com/science/article/pii/S1097276523008547
  38. www.sciencedirect.com www.sciencedirect.com
    Insulin receptor loss impairs mammary tumorigenesis in mice
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113251

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    sciencedirect.com/science/article/pii/S2211124723012639
  39. Oct 2023
  40. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
      RRID:AB_331679

      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  41. www.sciencedirect.com www.sciencedirect.com
    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.001

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    sciencedirect.com/science/article/pii/S1535610823003185
  42. Sep 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
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      DOI: 10.4103/1673-5374.379051

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    ncbi.nlm.nih.gov/pmc/articles/PMC10503613/
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    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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      DOI: 10.1016/j.chembiol.2023.08.007

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    sciencedirect.com/science/article/abs/pii/S2451945623002799
  45. Aug 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
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      DOI: 10.1158/1940-6207.CAPR-22-0275

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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  47. Jul 2023
  48. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
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    Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis
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      DOI: 10.1016/j.celrep.2023.112802

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      RRID:cAB_331679

      DOI: 10.1016/j.celrep.2023.112802

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    sciencedirect.com/science/article/pii/S2211124723008136
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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      AB_331679

      DOI: 10.1158/1535-7163.MCT-22-0147

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
  51. Jun 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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      RRID:AB_331679

      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
  53. www.sciencedirect.com www.sciencedirect.com
    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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      DOI: 10.1016/j.cell.2023.05.043

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    sciencedirect.com/science/article/pii/S0092867423005950
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
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      DOI: 10.1016/j.xcrm.2023.101073

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  108. Mar 2022
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  112. Dec 2021
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  114. Nov 2021
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  120. Sep 2021
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  124. Aug 2021
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    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
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  135. Jul 2021
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    Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice - ScienceDirect
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    Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function
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  139. Jun 2021
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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  141. May 2021
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    Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
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    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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  146. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
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  152. Feb 2021
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    ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation - Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok, 2021
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    Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome
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  157. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms
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  204. www.sciencedirect.com www.sciencedirect.com
    The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
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  207. academic.oup.com academic.oup.com
    Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    sciencedirect.com/science/article/pii/S2211124718310453
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    sciencedirect.com/science/article/pii/S1534580717308249
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    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice
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  213. www.ebiomedicine.com www.ebiomedicine.com
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    ebiomedicine.com/article/S2352-3964(18)30152-X/abstract
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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  215. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
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    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  219. Nov 2017
  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
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    Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration
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    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
    1
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      Rabbit anti-phospho-S6 Ribosomal Protein (Ser235/236)Cell Signaling TechnologyCat#2211

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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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  225. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  226. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14096/full
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    Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors
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      Cell Signaling Technology Cat# 2211, RRID: AB_331679

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      AB_331679

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