170 Matching Annotations
  1. Apr 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11008188/
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    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
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    1. scibot 05 Apr 2024
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    sciencedirect.com/science/article/pii/S1934590924000845
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    Sexual Dimorphism of Circadian Liver Transcriptome.
    1
    1. scibot 03 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973666/
  5. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    1. scibot 27 Feb 2024
      Cell Signaling Technology#2211

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    sciencedirect.com/science/article/pii/S2589004224003420
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
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    1. scibot 03 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830855/
  8. Jan 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    1. scibot 05 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  10. Dec 2023
  11. www.sciencedirect.com www.sciencedirect.com
    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
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    1. scibot 15 Dec 2023
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    sciencedirect.com/science/article/pii/S0969996123003868
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    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
    1
    1. scibot 02 Dec 2023
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  14. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276523008547
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    1. scibot 02 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723012639
  17. Oct 2023
  18. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    1. scibot 13 Oct 2023
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    sciencedirect.com/science/article/pii/S1535610823003185
  20. Sep 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
    1
    1. scibot 20 Sep 2023
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      DOI: 10.4103/1673-5374.379051

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    ncbi.nlm.nih.gov/pmc/articles/PMC10503613/
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    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.chembiol.2023.08.007

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    sciencedirect.com/science/article/abs/pii/S2451945623002799
  23. Aug 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1158/1940-6207.CAPR-22-0275

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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  25. Jul 2023
  26. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    1. scibot 27 Jul 2023
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    sciencedirect.com/science/article/pii/S2211124723008793
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    Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis
    3
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112802

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      DOI: 10.1016/j.celrep.2023.112802

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    sciencedirect.com/science/article/pii/S2211124723008136
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
    1
    1. scibot 06 Jul 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
  29. Jun 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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      DOI: 10.1016/j.cell.2023.05.043

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    sciencedirect.com/science/article/pii/S0092867423005950
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
    1
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    sciencedirect.com/science/article/pii/S2666379123001921
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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      DOI: 10.1016/j.isci.2023.106895

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    sciencedirect.com/science/article/pii/S2589004223009720
  34. May 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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    1. scibot 25 May 2023
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    sciencedirect.com/science/article/pii/S155041312300178X
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    1. scibot 20 May 2023
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      DOI: 10.1016/j.celrep.2023.112530

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    sciencedirect.com/science/article/pii/S2211124723005417
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    LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
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    sciencedirect.com/science/article/pii/S1097276523002885
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
    1
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      DOI: 10.1016/j.celrep.2022.111092

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    sciencedirect.com/science/article/pii/S2211124722008944
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
    1
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      DOI: 10.1016/j.celrep.2022.111085

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    sciencedirect.com/science/article/pii/S2211124722008877
  40. 52.53.155.43 52.53.155.43
    Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model
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      DOI: 10.36922/an.v1i3.153

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    52.53.155.43/438598aeab07baaec772d6c22da43b4baf80f7c8/202211301546121b45a6671-html.html
  41. Apr 2023
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    NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
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    sciencedirect.com/science/article/pii/S2211124723003832
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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    sciencedirect.com/science/article/pii/S1550413123001249
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S266637912300112X
  45. Mar 2023
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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      DOI: 10.1016/j.cell.2023.02.037

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    sciencedirect.com/science/article/pii/S0092867423002155
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    A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans
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    sciencedirect.com/science/article/pii/S1074761323000948
  48. Feb 2023
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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      DOI: 10.1111/jnc.15771

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    onlinelibrary.wiley.com/doi/epdf/10.1111/jnc.15771
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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      DOI: 10.1016/j.isci.2023.105962

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  51. Jan 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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      DOI: 10.1158/1078-0432.CCR-22-0421

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    ncbi.nlm.nih.gov/pmc/articles/PMC9306355/
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    A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
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    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
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    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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      DOI: 10.1096/fj.201902305R

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  157. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
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      Phospho-S6 Ribosomal Protein (Ser235/236)

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  158. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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      RRID:AB_331679

      DOI: 10.1016/j.celrep.2020.107568

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  159. Jan 2020
  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
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      DOI: 10.1002/yea.3351

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    Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
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    Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma
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  163. www.frontiersin.org www.frontiersin.org
    KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae
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  164. www.eneuro.org www.eneuro.org
    Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury
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    Mechanisms of Convergent Egg Provisioning in Poison Frogs
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  166. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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  167. www.sciencedirect.com www.sciencedirect.com
    Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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      RRID:AB_331679

      DOI: 10.1016/j.ccell.2018.10.001

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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.cell.2019.01.017

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      DOI: 10.1016/j.cmet.2019.04.003

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  176. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
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      RRID:AB_331679

      DOI: 10.1016/j.neuron.2019.02.018

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    PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress
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      DOI: 10.1016/j.stem.2019.03.019

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    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
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      RRID:AB_331679

      DOI: 10.1016/j.cmet.2018.10.005

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    sciencedirect.com/science/article/pii/S1550413118306375
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      DOI: 10.1016/j.cell.2018.11.030

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  180. Nov 2018
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    Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
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    The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
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    Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice
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  191. www.ebiomedicine.com www.ebiomedicine.com
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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  193. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  197. Nov 2017
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  199. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
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      RRID:AB_331679

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    sciencedirect.com/science/article/pii/S1534580717305968
  200. www.jneurosci.org www.jneurosci.org
    Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration
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    jneurosci.org/content/37/28/6786
  201. www.sciencedirect.com www.sciencedirect.com
    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
    1
    1. scibot 08 Nov 2017
      Rabbit anti-phospho-S6 Ribosomal Protein (Ser235/236)Cell Signaling TechnologyCat#2211

      Curator: @Jmenke

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      RRID:AB_331679 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417304282
  202. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517304914
  203. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
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    1. scibot 08 Nov 2017
      AB_331679

      Curator: @chewbeccax

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14096/full
  205. www.sciencedirect.com www.sciencedirect.com
    Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation
    1
    1. scibot 08 Nov 2017
      AB_331679

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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    sciencedirect.com/science/article/pii/S1550413117303005
  206. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082
  207. elifesciences.org elifesciences.org
    Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors
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    1. scibot 08 Nov 2017
      Cell Signaling Technology Cat# 2211, RRID: AB_331679

      Curator: @bandrow

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      RRID:AB_331679
    2. scibot 08 Nov 2017
      AB_331679

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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    elifesciences.org/content/5/e17111