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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    1. scibot 18 Jul 2024
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  3. Jun 2024
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    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  5. May 2024
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    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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    Glutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hypo-responsiveness
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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      DOI: 10.7554/eLife.89100

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  10. Apr 2024
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    Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia
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    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
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    Sexual Dimorphism of Circadian Liver Transcriptome.
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  14. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
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  17. Jan 2024
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    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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  19. Dec 2023
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    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
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    sciencedirect.com/science/article/pii/S0969996123003868
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    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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    1. scibot 02 Dec 2023
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      DOI: 10.1152/japplphysiol.00247.2022

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    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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  23. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124723012639
  26. Oct 2023
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    sciencedirect.com/science/article/pii/S1535610823003185
  29. Sep 2023
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    Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
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      DOI: 10.4103/1673-5374.379051

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    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    sciencedirect.com/science/article/abs/pii/S2451945623002799
  32. Aug 2023
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    Short-term PI3K inhibition prevents breast cancer in preclinical models
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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  34. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis
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    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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  38. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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    sciencedirect.com/science/article/pii/S0092867423005950
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
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    sciencedirect.com/science/article/pii/S2666379123001921
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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  43. May 2023
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    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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    sciencedirect.com/science/article/pii/S155041312300178X
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    sciencedirect.com/science/article/pii/S2211124723005417
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    LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
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    sciencedirect.com/science/article/pii/S1097276523002885
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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    sciencedirect.com/science/article/pii/S2211124722008944
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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    sciencedirect.com/science/article/pii/S2211124722008877
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    Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model
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  50. Apr 2023
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    NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
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    sciencedirect.com/science/article/pii/S2211124723003832
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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    sciencedirect.com/science/article/pii/S1550413123001249
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
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    Regulation of Hippocampal Memory by mTORC1 in Somatostatin Interneurons
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation
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    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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      RRID:AB_331679

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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      RRID:AB_331679
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
    1
    1. scibot 05 Nov 2018
      AB_331679

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
  203. www.jneurosci.org www.jneurosci.org
    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
    1
    1. scibot 05 Nov 2018
      331679

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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    jneurosci.org/content/38/11/2780
  204. www.sciencedirect.com www.sciencedirect.com
    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
    1
    1. scibot 05 Nov 2018
      RRID:AB_331679

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    sciencedirect.com/science/article/pii/S1535610817305159
  205. www.sciencedirect.com www.sciencedirect.com
    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
    1
    1. scibot 05 Nov 2018
      RRID:AB_331679

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    sciencedirect.com/science/article/pii/S0092867417312631
  206. Nov 2017
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
    1
    1. scibot 08 Nov 2017
      RRID:AB_331679

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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  208. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_331679

      Curator: @Jmenke

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      RRID:AB_331679 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717305968
  209. www.jneurosci.org www.jneurosci.org
    Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration
    1
    1. scibot 08 Nov 2017
      RRID:AB_331679

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    jneurosci.org/content/37/28/6786
  210. www.sciencedirect.com www.sciencedirect.com
    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
    1
    1. scibot 08 Nov 2017
      Rabbit anti-phospho-S6 Ribosomal Protein (Ser235/236)Cell Signaling TechnologyCat#2211

      Curator: @Jmenke

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      RRID:AB_331679 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417304282
  211. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
    1. scibot 08 Nov 2017
      RRID:AB_331679

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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      RRID:AB_331679 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517304914
  212. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
    1
    1. scibot 08 Nov 2017
      AB_331679

      Curator: @chewbeccax

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      RRID:AB_331679 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  213. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance
    1
    1. scibot 08 Nov 2017
      AB_331679

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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      RRID:AB_331679 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14096/full
  214. www.sciencedirect.com www.sciencedirect.com
    Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation
    1
    1. scibot 08 Nov 2017
      AB_331679

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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      RRID:AB_331679 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413117303005
  215. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
    1
    1. scibot 08 Nov 2017
      AB_331679

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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    sciencedirect.com/science/article/pii/S2405471216304082
  216. elifesciences.org elifesciences.org
    Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors
    2
    1. scibot 08 Nov 2017
      Cell Signaling Technology Cat# 2211, RRID: AB_331679

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

      SciCrunch record: RRID:AB_331679

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      RRID:AB_331679
    2. scibot 08 Nov 2017
      AB_331679

      Resource used:

      (Cell Signaling Technology Cat# 2211, RRID:AB_331679)

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      RRID:AB_331679
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    elifesciences.org/content/5/e17111