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Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

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1. scibot 10 Sep 2025
  
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  DOI: 10.7554/eLife.104138
  
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Ketone body β-Hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome

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1. scibot 07 Sep 2025
  
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  DOI: 10.1152/ajpcell.00453.2025
  
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Aug 2025
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Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116177
  
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Type I interferon signaling promotes kainic acid-induced seizures through mTOR activation

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110634
  
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

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Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

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1. scibot 13 Aug 2025
  
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Olfactory Nerve Transection Transiently Activates Olfactory Ensheathing Cells in Xenopus laevis Larvae

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1. scibot 05 Aug 2025
  
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  DOI: 10.1111/ejn.70211
  
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aryal-et-al-2025-ketone-body--hydroxybutyrate-mediated-histone--hydroxybutyrylation-upregulates-lipolysis-and-html.html

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1. scibot 01 Aug 2025
  
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  DOI: 10.6084/m9.figshare.29545829.v1
  
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Jul 2025
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 25 Jul 2025
  
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1-s2.0-S2589004225014555-main-html.html

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1. scibot 25 Jul 2025
  
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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1. scibot 16 Jul 2025
  
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The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

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1. scibot 02 Jul 2025
  
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  DOI: 10.1210/endocr/bqae041
  
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dx.doi.org/10.1210/endocr/bqae041
Jun 2025
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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115851
  
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RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis

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1. scibot 12 Jun 2025
  
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  DOI: 10.1186/s12964-025-02278-w
  
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Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2767-9764.CRC-23-0506
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141995/
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.003
  
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Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors

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1. scibot 20 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.041
  
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The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110487
  
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sciencedirect.com/science/article/pii/S0028390825001935
Mar 2025
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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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1. scibot 26 Mar 2025
  
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  DOI: 10.1101/2025.03.20.644389
  
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Vagal pathway activation links chronic stress to decline in intestinal stem cell function

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  DOI: 10.1016/j.stem.2025.02.016
  
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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Safety and Efficacy of Copanlisib in Combination with Nivolumab: A Phase Ib Study in Patients with Advanced Solid Tumors

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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

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  DOI: 10.1016/j.ccell.2025.02.018
  
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Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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  DOI: 10.1016/j.celrep.2025.115340
  
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Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy

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  DOI: 10.1016/j.xpro.2024.103587
  
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Jan 2025
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Lactate homeostasis is maintained through regulation of glycolysis and lipolysis

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  DOI: 10.1016/j.cmet.2024.12.009
  
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Postprandial parasympathetic signals promote lung type 2 immunity

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  DOI: 10.1016/j.neuron.2024.12.020
  
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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  DOI: 10.1016/j.celrep.2024.115179
  
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Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer

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  DOI: 10.1016/j.celrep.2024.115128
  
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Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

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  DOI: 10.7554/eLife.97654
  
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Bone marrow mesenchymal stromal cells support translation in refractory acute myeloid leukemia

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  DOI: 10.1016/j.celrep.2024.115151
  
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Dec 2024
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PDF-html.html

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

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1. scibot 11 Dec 2024
  
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  DOI: 10.1371/journal.pone.0314858
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
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Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells

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  DOI: 10.1016/j.devcel.2024.11.007
  
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sciencedirect.com/science/article/pii/S1534580724006725
Nov 2024
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Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R

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PTEN deletion in the adult dentate gyrus induces epilepsy

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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis

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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels

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mTOR activity paces human blastocyst stage developmental progression

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Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

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Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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A mouse model of endometriosis mimicking the natural spread of invasive endometrium

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Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

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PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY

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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients

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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease

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Hyperactive mTORC1 Disrupts Habenula Function and Light Preference in Zebrafish Model of Tuberous Sclerosis Complex

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC

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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model

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12958_2024_1204_MOESM1_ESM-html.html

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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway

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An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

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GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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An oncogenic phenoscape of colonic stem cell polarization

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Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses

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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

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Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest

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s11684-022-0959-5 (1)-html.html

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Brain regions controlling courtship behavior in the bluehead wrasse

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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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Synergistic effect of chemogenetic activation of corticospinal motoneurons and physical exercise in promoting functional recovery after spinal cord injury

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FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia

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RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

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A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.

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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

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Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

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FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress

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Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases

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cd-23-0475-html.html

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IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months

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Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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May 2023
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s11684-022-0959-5-html.html

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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  DOI: 10.4049/jimmunol.2200351
  
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The p-rpS6-zone delineates wounding responses and the healing process

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

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Mar 2023
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Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers

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Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells

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Feb 2023
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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

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Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

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Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells

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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

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Satellite glia modulate sympathetic neuron survival, activity, and autonomic function

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Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

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Aug 2022
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can-21-2908-html.html

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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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Jul 2022
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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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Context-dependent regulation of ferroptosis sensitivity

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Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response

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Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model

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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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Translational Strategies for Repotrectinib in Neuroblastoma

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Apr 2022
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IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide

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Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

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Coordinated changes in glycosylation regulate the germinal center through CD22

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice

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Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

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AKT signaling downstream of KGF is necessary and sufficient for blocking cyclophosphamide bladder injury

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Mosaic dysfunction of mitophagy in mitochondrial muscle disease

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases

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Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice

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The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

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Oxytocin-like receptor expression in evolutionarily conserved nodes of a vocal network associated with male courtship in a teleost fish

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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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A Role for Translational Regulation by S6 Kinase and a Downstream Target in Inflammatory Pain

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Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

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Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2

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Involvement of multiple scavenger receptors in advanced glycation end product-induced vessel tube formation in endothelial cells

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Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

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Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

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Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study

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Untitled document

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer

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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model

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Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

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A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat.

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

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Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells

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TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis

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