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    Comprehensive proteogenomic characterization of rare kidney tumors
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      Cell Signaling TechnologyCatalog: 4376

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    sciencedirect.com/science/article/pii/S2666379124002398
  3. Apr 2024
  4. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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      AB_331772

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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S1534580724001837
  6. Mar 2024
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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  8. Nov 2023
  9. dx.doi.org dx.doi.org
    Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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  12. Oct 2023
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    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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    Regulation of ERK2 activity by dynamic S-acylation
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    sciencedirect.com/science/article/pii/S2211124723011476
  15. Sep 2023
  16. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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  17. Jul 2023
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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  19. Jun 2023
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    aacrjournals.org/cancerres/article/83/7/1128/718992/ROS-Induction-Targets-Persister-Cancer-Cells-with
  23. aacrjournals.org aacrjournals.org
    Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities
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    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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  25. May 2023
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    NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells
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  27. Apr 2023
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    ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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  30. Jan 2023
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    Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice
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      AB_331772

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  32. Dec 2022
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    sciencedirect.com/science/article/pii/S2211124722017296
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
  35. Nov 2022
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    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
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  38. Oct 2022
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    K+ channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation
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  40. journals.lww.com journals.lww.com
    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.344952

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  41. Sep 2022
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    NS5806 inhibits ERK activation to attenuate pain induced by peripheral nerve injury
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    PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
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      DOI: 10.1158/2159-8290.CD-21-0694

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904293/
  44. Aug 2022
  45. www.nature.com www.nature.com
    Molecular neurobiological markers in the onset of sodium appetite
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      DOI: 10.1038/s41598-022-18220-w

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    nature.com/articles/s41598-022-18220-w
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    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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    sciencedirect.com/science/article/pii/S2211124722009809
  47. Jul 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610822002756
  49. Jun 2022
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  51. Apr 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    sciencedirect.com/science/article/pii/S2589004222004813
  53. www.sciencedirect.com www.sciencedirect.com
    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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    sciencedirect.com/science/article/pii/S221112472200393X
  54. Mar 2022
  55. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.14558

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14558
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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      DOI: 10.1038/s41598-022-07600-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33947
  58. Feb 2022
  59. www.sciencedirect.com www.sciencedirect.com
    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
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    sciencedirect.com/science/article/pii/S221112472200095X
  60. www.embopress.org www.embopress.org
    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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      DOI: 10.15252/emmm.202114876

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  61. Jan 2022
  62. academic.oup.com academic.oup.com
    Regulation of mouse primordial follicle formation by signaling through the PI3K pathway
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      DOI: 10.1093/biolre/ioab204

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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      DOI: 10.1016/j.ccell.2019.04.011

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  64. Nov 2021
  65. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  66. Sep 2021
  67. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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      4376

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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
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  69. Aug 2021
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  71. academic.oup.com academic.oup.com
    TSH activates macrophage inflammation by G13 and G15-dependent pathways
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  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response
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  73. Jul 2021
  74. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways
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  75. www.nature.com www.nature.com
    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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      Phospho-Erk 1/2

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
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  78. www.sciencedirect.com www.sciencedirect.com
    Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
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  79. Jun 2021
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    TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways
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    D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling
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  82. Apr 2021
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    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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  86. Mar 2021
  87. www.sciencedirect.com www.sciencedirect.com
    Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs
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  88. Feb 2021
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    Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
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  90. Jan 2021
  91. link.springer.com link.springer.com
    Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitro
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  92. Oct 2020
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin
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      DOI: 10.1186/s12974-020-01965-4

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  94. Sep 2020
  95. www.sciencedirect.com www.sciencedirect.com
    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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      DOI: 10.1016/j.celrep.2020.107835

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    Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics
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  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling
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    The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation
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      Rabbit monoclonal anti- phospho-p44/42 MAPK

      DOI: 10.1016/j.celrep.2020.107781

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  99. Jan 2020
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    GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
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      RRID:AB_331772

      DOI: 10.1016/j.stem.2019.06.004

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    A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
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    Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection
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      DOI: 10.1111/jnc.14476

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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  115. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Protein inhibitor of activated STAT1 Ser503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice
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    Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    Adenosine A2A receptors are required for Glutamate mGluR5‐ and Dopamine D1 receptor‐evoked ERK1/2 phosphorylation in rat Hippocampus: Involvement of NMDA receptor
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    Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR
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    Inhibition of A-Type K+ Channels by Urotensin-II Induces Sensory Neuronal Hyperexcitability Through the PKCα-ERK Pathway
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    An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
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  128. Nov 2017
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    Mechanisms of Enhanced Phrenic Long-Term Facilitation in <i>SOD1<sup>G93A</sup></i> Rats
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    Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma
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