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Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.chembiol.2026.09.006
  
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sciencedirect.com/science/article/pii/S245194562600334X
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Targeting adaptive EGFR feedback enhances the therapeutic efficacy of RMC-6236 in cholangiocarcinoma

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1. scibot 06 Oct 2026
  
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  DOI: 10.1186/s40164-026-00835-8
  
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link.springer.com/article/10.1186/s40164-026-00835-8
Sep 2026
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Thirst reweights temperature preference through dual dopaminergic and endocrine modulation in Drosophila

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1. scibot 24 Sep 2026
  
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  DOI: 10.1016/j.cub.2026.08.062
  
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2. scibot 24 Sep 2026
  
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  DOI: 10.1016/j.cub.2026.08.062
  
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sciencedirect.com/science/article/pii/S0960982226011140
Jul 2026
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A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117668
  
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sciencedirect.com/science/article/pii/S2211124726007461
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Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior

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1. scibot 04 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116615
  
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sciencedirect.com/science/article/pii/S2589004226019917
Jun 2026
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The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116500
  
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sciencedirect.com/science/article/pii/S2589004226018754
May 2026
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A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.ccell.2026.03.021
  
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sciencedirect.com/science/article/pii/S1535610826001753
Apr 2026
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Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer

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1. scibot 12 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0562
  
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aacrjournals.org/mct/article/25/4/599/776467/Mosperafenib-a-Novel-Paradox-Breaker-BRAF
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MiR-1202 increases radioresistance in nasopharyngeal carcinoma by targeting NAIF1/MAPK/ERK pathway

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1. scibot 09 Apr 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13053778/
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Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases

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1. scibot 02 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-24-0618
  
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aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
Mar 2026
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MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

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1. scibot 27 Mar 2026
  
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  DOI: 10.1084/jem.20251497
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13016079/
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IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members

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1. scibot 06 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117054
  
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sciencedirect.com/science/article/pii/S2211124726001324
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Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis

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1. scibot 03 Mar 2026
  
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  DOI: 10.1038/s41467-026-69899-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12946193/
Dec 2025
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Immunohistochemical distribution of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the rat carotid body

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1. scibot 04 Dec 2025
  
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  DOI: 10.1016/j.tice.2025.103247
  
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sciencedirect.com:5037/science/article/pii/S0040816625005294
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RAS(ON) multi-selective inhibition drives antitumor immunity in preclinical models of NRAS-mutant melanoma

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1. scibot 03 Dec 2025
  
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  DOI: 10.1158/2326-6066.CIR-25-0744
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666865/
Nov 2025
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Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.11.002
  
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sciencedirect.com/science/article/pii/S0092867425012516
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EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

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1. scibot 23 Nov 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1417
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12479099/
Oct 2025
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Jul 2025
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RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma

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1. scibot 25 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3819
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281470/
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The immune response against cancer is modulated by stromal cell fibronectin

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  DOI: 10.1016/j.neo.2025.101196
  
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sciencedirect.com/science/article/pii/S1476558625000764
Apr 2025
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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115541
  
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sciencedirect.com/science/article/pii/S2211124725003122
Mar 2025
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GEF-H1 drives breast cancer cells to tumor progression

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.bbadis.2025.167816
  
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sciencedirect.com/science/article/pii/S0925443925001619
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The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors

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1. scibot 13 Mar 2025
  
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  DOI: 10.1124/molpharm.124.000939
  
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sciencedirect.com/science/article/pii/S0026895X24120111
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Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines

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1. scibot 05 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115352
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00123-8
Feb 2025
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Overexpression of NR1D1 portends disease recurrence in thyroid cancer

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/clinem/dgae687
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae687/7808457
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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115286
  
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sciencedirect.com/science/article/pii/S2211124725000579
Sep 2024
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Functional Regeneration of the Sensory Root via Axonal Invasion

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2019.12.008
  
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sciencedirect.com/science/article/pii/S221112471931647X
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Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma

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  DOI: 10.1016/j.isci.2024.110635
  
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H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response

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  DOI: 10.1016/j.celrep.2024.114686
  
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sciencedirect.com/science/article/pii/S2211124724010374
Aug 2024
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EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

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1. scibot 21 Aug 2024
  
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  DOI: 10.1371/journal.pbio.3000027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6231689/
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Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model

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1. scibot 21 Aug 2024
  
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  DOI: 10.1093/pnasnexus/pgae299
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11305140/
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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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1. scibot 02 Aug 2024
  
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  DOI: 10.1038/s41408-021-00603-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
May 2024
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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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1. scibot 09 May 2024
  
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  DOI: 10.1210/endocr/bqae039
  
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dx.doi.org/10.1210/endocr/bqae039
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bqae039-html.html

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1. scibot 09 May 2024
  
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  DOI: 10.6084/m9.figshare.24398467.v2
  
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2. scibot 09 May 2024
  
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  DOI: 10.1210/endocr/bqae039
  
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Comprehensive proteogenomic characterization of rare kidney tumors

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β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo

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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice

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HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

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ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis

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Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine

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Regulation of ERK2 activity by dynamic S-acylation

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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart

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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

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ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

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Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2

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NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells

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ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis

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RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis

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Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice

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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

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Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions

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A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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Oct 2022
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K+ channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation

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Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research

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Sep 2022
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NS5806 inhibits ERK activation to attenuate pain induced by peripheral nerve injury

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PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

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ncbi.nlm.nih.gov/pmc/articles/PMC8904293/
Aug 2022
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Molecular neurobiological markers in the onset of sodium appetite

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  DOI: 10.1038/s41598-022-18220-w
  
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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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Jun 2022
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Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
Apr 2022
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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

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Mar 2022
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BPS Publications

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Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist

1
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Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9

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BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer

1
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Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems

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Regulation of mouse primordial follicle formation by signaling through the PI3K pathway

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

1
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Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

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NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis

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Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway

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Untitled document

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TSH activates macrophage inflammation by G13 and G15-dependent pathways

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High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response

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Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways

2
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  RRID:AB_331772
  
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Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment

1
1. scibot 29 Jul 2021
  
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  Phospho-Erk 1/2
  
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Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

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Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

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TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways

1
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  y
  
  DOI: 10.1016/j.ebiom.2021.103370
  
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D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs

1
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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

1
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Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitro

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Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin

1
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Sep 2020
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Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice

1
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Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

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Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

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The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation

1
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  Rabbit monoclonal anti- phospho-p44/42 MAPK
  
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GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

1
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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

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  DOI: 10.1016/j.celrep.2019.07.070
  
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

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Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking

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Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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Protein inhibitor of activated STAT1 Ser503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice

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Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells

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CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

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Ouabain increases neuronal branching in hippocampus and improves spatial memory

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Adenosine A2A receptors are required for Glutamate mGluR5‐ and Dopamine D1 receptor‐evoked ERK1/2 phosphorylation in rat Hippocampus: Involvement of NMDA receptor

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Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR

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Inhibition of A-Type K+ Channels by Urotensin-II Induces Sensory Neuronal Hyperexcitability Through the PKCα-ERK Pathway

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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

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Discovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse

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Evidence for Pro-angiogenic Functions of VEGF-Ax

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Mechanisms of Enhanced Phrenic Long-Term Facilitation in <i>SOD1<sup>G93A</sup></i> Rats

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Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma

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