127 Matching Annotations
  1. May 2026
  2. www.sciencedirect.com www.sciencedirect.com
    A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1535610826001753
  3. Apr 2026
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    Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer
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    aacrjournals.org/mct/article/25/4/599/776467/Mosperafenib-a-Novel-Paradox-Breaker-BRAF
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MiR-1202 increases radioresistance in nasopharyngeal carcinoma by targeting NAIF1/MAPK/ERK pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13053778/
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    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
  7. Mar 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13016079/
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    IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members
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    sciencedirect.com/science/article/pii/S2211124726001324
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12946193/
  11. Dec 2025
  12. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Immunohistochemical distribution of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the rat carotid body
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    sciencedirect.com:5037/science/article/pii/S0040816625005294
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    RAS(ON) multi-selective inhibition drives antitumor immunity in preclinical models of NRAS-mutant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12666865/
  14. Nov 2025
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    Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
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    sciencedirect.com/science/article/pii/S0092867425012516
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    EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12479099/
  17. Oct 2025
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281470/
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    The immune response against cancer is modulated by stromal cell fibronectin
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    sciencedirect.com/science/article/pii/S1476558625000764
  22. Apr 2025
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  24. Mar 2025
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    GEF-H1 drives breast cancer cells to tumor progression
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    sciencedirect.com/science/article/pii/S0925443925001619
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    The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors
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    sciencedirect.com/science/article/pii/S0026895X24120111
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    Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines
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    cell.com/cell-reports/fulltext/S2211-1247(25)00123-8
  28. Feb 2025
  29. academic.oup.com academic.oup.com
    Overexpression of NR1D1 portends disease recurrence in thyroid cancer
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae687/7808457
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    The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells
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  31. Sep 2024
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    Functional Regeneration of the Sensory Root via Axonal Invasion
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    Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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  35. Aug 2024
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11305140/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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  39. May 2024
  40. dx.doi.org dx.doi.org
    The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway
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    dx.doi.org/10.1210/endocr/bqae039
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    Comprehensive proteogenomic characterization of rare kidney tumors
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  43. Apr 2024
  44. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    dx.doi.org/10.1210/endocr/bqae044
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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  46. Mar 2024
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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  48. Nov 2023
  49. dx.doi.org dx.doi.org
    Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice
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    dx.doi.org/10.1210/endocr/bqad173
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10644579/
  52. Oct 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
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    Regulation of ERK2 activity by dynamic S-acylation
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  55. Sep 2023
  56. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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    embopress.org/doi/full/10.15252/embr.202356948
  57. Jul 2023
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
  59. Jun 2023
  60. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  61. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    science.org/doi/10.1126/sciadv.ade1155
  62. aacrjournals.org aacrjournals.org
    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    aacrjournals.org/cancerres/article/83/7/1128/718992/ROS-Induction-Targets-Persister-Cancer-Cells-with
  63. aacrjournals.org aacrjournals.org
    Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities
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    aacrjournals.org/cancerres/article/83/6/890/718574/Olig1-2-Expressing-Intermediate-Lineage
  64. www.sciencedirect.com www.sciencedirect.com
    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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    sciencedirect.com/science/article/pii/S2589004223009914
  65. May 2023
  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells
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    onlinelibrary.wiley.com/doi/10.1002/ejp.2123
  67. Apr 2023
  68. www.biorxiv.org www.biorxiv.org
    ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    biorxiv.org/content/10.1101/2023.03.22.533821v1
  69. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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    embopress.org/doi/10.15252/emmm.202217078
  70. Jan 2023
  71. academic.oup.com academic.oup.com
    Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice
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    academic.oup.com/endo/article/164/3/bqac214/6969391
  72. Dec 2022
  73. www.sciencedirect.com www.sciencedirect.com
    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    sciencedirect.com/science/article/pii/S2211124722017296
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
  75. Nov 2022
  76. www.mdpi.com www.mdpi.com
    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
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    mdpi.com/2073-4409/11/22/3665
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
  78. Oct 2022
  79. onlinelibrary.wiley.com onlinelibrary.wiley.com
    K+ channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation
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    onlinelibrary.wiley.com/doi/10.1002/ejp.2038
  80. journals.lww.com journals.lww.com
    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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  81. Sep 2022
  82. www.sciencedirect.com www.sciencedirect.com
    NS5806 inhibits ERK activation to attenuate pain induced by peripheral nerve injury
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8904293/
  84. Aug 2022
  85. www.nature.com www.nature.com
    Molecular neurobiological markers in the onset of sodium appetite
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    nature.com/articles/s41598-022-18220-w
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    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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  87. Jul 2022
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    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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  89. Jun 2022
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  91. Apr 2022
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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  94. Mar 2022
  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14558
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
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    Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33947
  98. Feb 2022
  99. www.sciencedirect.com www.sciencedirect.com
    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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    embopress.org/doi/abs/10.15252/emmm.202114876
  101. Jan 2022
  102. academic.oup.com academic.oup.com
    Regulation of mouse primordial follicle formation by signaling through the PI3K pathway
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioab204/6414948
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  104. Nov 2021
  105. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  106. Sep 2021
  107. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC8431595/
  109. Aug 2021
  110. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    TSH activates macrophage inflammation by G13 and G15-dependent pathways
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    academic.oup.com/endo/article/162/8/bqab077/6225351
  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23996/full
  113. Jul 2021
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways
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    onlinelibrary.wiley.com/doi/full/10.1002/jnr.24324
  115. www.nature.com www.nature.com
    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC6218484/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
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    ncbi.nlm.nih.gov/pmc/articles/PMC8238509/
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    Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
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  119. Jun 2021
  120. www.sciencedirect.com www.sciencedirect.com
    TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways
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    sciencedirect.com/science/article/pii/S2352396421001638
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    D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling
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  122. Apr 2021
  123. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0092867420313222
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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