45 Matching Annotations
  1. Jul 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
    1
    1. scibot 30 Jul 2024
      AB_398107

      DOI: 10.1016/j.neuron.2024.06.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  3. www.biorxiv.org www.biorxiv.org
    Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits
    1
    1. scibot 23 Jul 2024
      RRID:AB_398107

      DOI: 10.1101/2024.07.09.602700

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    biorxiv.org/content/10.1101/2024.07.09.602700v1
  4. May 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
    2
    1. scibot 24 May 2024
      RRID:AB_398107

      DOI: 10.1038/s41531-024-00679-1

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    2. scibot 24 May 2024
      RRID:AB_398107

      DOI: 10.1038/s41531-024-00679-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11109094/
  6. Jan 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
    1
    1. scibot 18 Jan 2024
      AB_398107

      DOI: 10.1016/j.ebiom.2023.104887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709029/
  8. Jun 2023
  9. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
      RRID:AB_398107

      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  10. Mar 2023
  11. www.sciencedirect.com www.sciencedirect.com
    Neuronal identity defines α-synuclein and tau toxicity
    1
    1. scibot 28 Mar 2023
      RRID:AB_398107

      DOI: 10.1016/j.neuron.2023.02.033

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    sciencedirect.com/science/article/pii/S0896627323001666
  12. Jan 2023
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions
    1
    1. scibot 19 Jan 2023
      RRID:AB_398107

      DOI: 10.1523/JNEUROSCI.0680-22.2022

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    pmc.ncbi.nlm.nih.gov/articles/PMC9864632/
  14. Nov 2022
  15. movementdisorders.onlinelibrary.wiley.com movementdisorders.onlinelibrary.wiley.com
    Nicotine-Mediated Rescue of α-Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila
    1
    1. scibot 24 Nov 2022
      RRID:AB_398107

      DOI: 10.1002/mds.29283

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    movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29283
  16. Jun 2022
  17. 52.53.155.43 52.53.155.43
    Occurrence of Total and Proteinase K-Resistant Alpha-Synuclein in Glioblastoma Cells Depends on mTOR Activity
    1
    1. scibot 23 Jun 2022
      AB_398107

      DOI: 10.3390/cancers14061382

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    52.53.155.43/4deaece5f576ac127195ceba06752c88cfcd6756/cancers-14-01382-v2-html.html
  18. May 2022
  19. www.sciencedirect.com www.sciencedirect.com
    PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
    1
    1. scibot 11 May 2022
      RRID:AB_398107

      DOI: 10.1016/j.cell.2022.04.020

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    sciencedirect.com/science/article/pii/S0092867422004676
  20. Nov 2021
  21. link.springer.com link.springer.com
    Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
    1
    1. scibot 09 Nov 2021
      RRID:AB_398107

      DOI: 10.1186/s40478-021-01283-7

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    link.springer.com/article/10.1186/s40478-021-01283-7
  22. Aug 2021
  23. www.biorxiv.org www.biorxiv.org
    Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity
    1
    1. scibot 13 Aug 2021
      RRID:AB_398107

      DOI: 10.1101/620401

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    biorxiv.org/content/10.1101/620401v1
  24. www.jneurosci.org www.jneurosci.org
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    1
    1. scibot 07 Aug 2021
      RRID:AB_398107

      DOI: 10.1523/JNEUROSCI.0632-14.2015

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    jneurosci.org/content/35/14/5724
  25. Jul 2021
  26. www.nature.com www.nature.com
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    1
    1. scibot 31 Jul 2021
      RRID:AB_398107

      DOI: 10.1038/s41598-018-33474-z

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    nature.com/articles/s41598-018-33474-z
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1
    1. scibot 28 Jul 2021
      RRID:AB_398107

      DOI: 10.1016/j.neuron.2017.01.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC5340420/
  28. www.jneurosci.org www.jneurosci.org
    Glucosylsphingosine promotes α-synuclein pathology in mutant GBA-associated Parkinson's disease
    3
    1. scibot 28 Jul 2021
      RRID:AB_398107

      DOI: 10.1523/JNEUROSCI.1525-17.2017

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      DOI: 10.1523/JNEUROSCI.1525-17.2017

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      DOI: 10.1523/JNEUROSCI.1525-17.2017

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    jneurosci.org/content/37/40/9617
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
    1
    1. scibot 27 Jul 2021
      610786

      DOI: 10.1002/cne.24468

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24468
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α‐synuclein
    1
    1. scibot 27 Jul 2021
      AB_398107

      DOI: 10.1002/jnr.23677

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23677/full
  31. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
    1
    1. scibot 23 Jul 2021
      RRID:AB_398107

      DOI: 10.1002/jnr.24927

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24927
  32. Jun 2021
  33. www.sciencedirect.com www.sciencedirect.com
    An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
    1
    1. scibot 09 Jun 2021
      RRID:AB_398107

      DOI: 10.1016/j.celrep.2021.109189

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    sciencedirect.com/science/article/pii/S2211124721005350
  34. Dec 2020
  35. link.springer.com link.springer.com
    Chronic MPTP in Mice Damage-specific Neuronal Phenotypes within Dorsal Laminae of the Spinal Cord
    1
    1. scibot 07 Dec 2020
      AB_398107

      DOI: 10.1007/s12640-020-00313-x

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    link.springer.com/article/10.1007/s12640-020-00313-x
  36. Nov 2020
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
    1
    1. scibot 27 Nov 2020
      RRID:AB_398107

      DOI: 10.1111/jnc.15174

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15174
  38. Sep 2020
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis
    1
    1. scibot 26 Sep 2020
      RRID:AB_398107

      DOI: 10.7554/eLife.58613

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    ncbi.nlm.nih.gov/pmc/articles/PMC7438114/
  40. www.sciencedirect.com www.sciencedirect.com
    Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
    1
    1. scibot 26 Sep 2020
      RRID:AB_398107

      DOI: 10.1016/j.celrep.2019.12.078

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    sciencedirect.com/science/article/pii/S2211124719317437
  41. link.springer.com link.springer.com
    Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
    1
    1. scibot 14 Sep 2020
      RRID:AB_398107

      DOI: 10.1186/s40478-020-01004-6

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    link.springer.com/article/10.1186/s40478-020-01004-6
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
    1
    1. scibot 12 Sep 2020
      RRID:AB_398107

      DOI: 10.1111/jnc.15107

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15107
  43. Jan 2020
  44. www.sciencedirect.com www.sciencedirect.com
    Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior
    1
    1. scibot 13 Jan 2020
      RRID:AB_398107

      DOI: 10.1016/j.celrep.2019.09.029

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    sciencedirect.com/science/article/pii/S2211124719312069
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein
    1
    1. scibot 13 Jan 2020
      RRID:AB_398107

      DOI: 10.1002/jnr.24513

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24513
  46. www.sciencedirect.com www.sciencedirect.com
    In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.10.089

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    sciencedirect.com/science/article/pii/S2211124719314111
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity
    1
    1. scibot 13 Jan 2020
      RRID:AB_398107

      DOI: 10.1038/s41598-019-54063-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC6879756/
  48. www.sciencedirect.com www.sciencedirect.com
    Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
    1
    1. scibot 13 Jan 2020
      RRID:AB_398107

      DOI: 10.1016/j.molcel.2018.11.028

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    sciencedirect.com/science/article/pii/S1097276518309985
  49. Nov 2018
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
    1
    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
  51. www.sciencedirect.com www.sciencedirect.com
    A new model to study cell-to-cell transfer of αSynuclein in vivo
    1
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    sciencedirect.com/science/article/pii/S0006291X1831547X
  52. www.sciencedirect.com www.sciencedirect.com
    Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity
    1
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    sciencedirect.com/science/article/pii/S1097276517306652
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin
    1
    1. scibot 05 Nov 2018
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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5701296/
  54. europepmc.org europepmc.org
    Untitled document
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    1. scibot 05 Nov 2018
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    europepmc.org/articles/PMC5701296/
  55. Nov 2017
  56. www.sciencedirect.com www.sciencedirect.com
    Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons
    1
    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0896627317300430
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α‐synuclein
    1
    1. scibot 08 Nov 2017
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      Curator: @gabimpine

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      RRID:AB_398107 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24024/full
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA
    1
    1. scibot 08 Nov 2017
      AB_398107

      Curator: @gabimpine

      Resource used:

      (BD Biosciences Cat# 610786, RRID:AB_398107)

      SciCrunch record: RRID:AB_398107

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_398107 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC4166159/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
    1
    1. scibot 08 Nov 2017
      AB_398107

      Curator: @gabimpine

      Resource used:

      (BD Biosciences Cat# 610786, RRID:AB_398107)

      SciCrunch record: RRID:AB_398107

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_398107 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC4388928/
  60. Dec 2015
  61. www.jneurosci.org www.jneurosci.org
    Untitled document
    1
    1. judell 21 Dec 2015
      AB_398107

      Antibody ID: AB_398107

      Target Antigen: Synuclein, alpha See NCBI gene

      Vendor: BD Biosciences

      Cat Num: 610786

      Proper Citation: (BD Biosciences Cat# 610786, RRID:AB_398107)

      Reference: PMID:17099894

      Clonality: monoclonal antibody

      Clone ID: None

      Host Organism: mouse

      Comments: manufacturer recommendations: Immunofluorescence; Immunoprecipitation; Western Blot; IF, IP, WB human, mouse, rat

      resolver lookup

      RRID:AB_398107
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    jneurosci.org/content/35/14/5724.long
  62. www.jneurosci.org www.jneurosci.org
    Untitled document
    1
    1. judell 17 Dec 2015
      AB_398107

      Antibody ID: AB_398107

      Target Antigen: Synuclein, alpha See NCBI gene

      Vendor: BD Biosciences

      Cat Num: 610786

      Proper Citation: (BD Biosciences Cat# 610786, RRID:AB_398107)

      Reference: PMID:17099894

      Clonality: monoclonal antibody

      Clone ID: None

      Host Organism: mouse

      Comments: manufacturer recommendations: Immunofluorescence; Immunoprecipitation; Western Blot; IF, IP, WB human, mouse, rat

      resolver lookup

      RRID:AB_398107
    Visit annotations in context

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    URL

    jneurosci.org/content/35/14/5724.full