528 Matching Annotations
  1. Aug 2025
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    A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
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    HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
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    RNA Pol II inhibition activates cell death independently from the loss of transcription
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    Multiomics Profiling of Extracellular Vesicles Supports Their Involvement in Endothelial Senescence‐Associated Vascular Dysfunction
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  6. Jul 2025
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    Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
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    Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
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    Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
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  11. Jun 2025
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    Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia
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    Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation
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    CRAMP1 drives linker histone expression to enable Polycomb repression
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    VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells
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    Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats
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  17. May 2025
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    The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer
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    A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation
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  21. Apr 2025
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    METTL3-mediated m6A modification regulates the polycomb repressive complex 1 (PRC1) components BMI1 and RNF2 in hepatocellular carcinoma cells
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    Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice
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  25. Mar 2025
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    Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation
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    APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease
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    SSAO-mediated decrease of endothelial BDNF release affects neuronal GluA1 and PSD95 expression: a peripheral mechanism inducing NVU and CNS disturbances
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  29. Feb 2025
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    Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo
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  34. Jan 2025
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    Central Downregulation of S-Resistin Alleviates Inflammation in EWAT and Liver and Prevents Adipocyte Hypertrophy
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    DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs
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  38. Dec 2024
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    Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
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  47. Nov 2024
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    A functional connection between the Microprocessor and a variant NEXT complex
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  49. Oct 2024
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    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling
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  54. Sep 2024
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    Tanomastat exerts multi-targeted inhibitory effects on viral capsid dissociation and RNA replication in human enteroviruses
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    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Key roles of C2/GAP domains in SYNGAP1-related pathophysiology
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  61. Aug 2024
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
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    M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival
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    Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
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  69. Jul 2024
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    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
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  73. Jun 2024
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  77. May 2024
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    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
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    Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis
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    Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases
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    Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly
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    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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    Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
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    Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells
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    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
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    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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  88. Apr 2024
  89. www.embopress.org www.embopress.org
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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    Standardized In Vitro Models of Human Adipose Tissue Reveal Metabolic Flexibility in Brown Adipocyte Thermogenesis
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    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
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    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
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  97. Mar 2024
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    Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress
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    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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  101. Feb 2024
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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