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Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity

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1. scibot 07 Apr 2026
  
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  DOI: 10.1080/2162402X.2026.2649988
  
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tandfonline.com/doi/full/10.1080/2162402X.2026.2649988
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress

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1. scibot 03 Mar 2026
  
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  DOI: 10.1038/s44319-026-00690-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12936171/
Jan 2026
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Mitotic chromatin compaction tethers extrachromosomal DNA to chromosomes and prevents their mis-segregation into micronuclei

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.jbc.2025.111081
  
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sciencedirect.com/science/article/pii/S0021925825029333
Dec 2025
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Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development

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1. scibot 30 Dec 2025
  
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  DOI: 10.7554/eLife.107947
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12680375/
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A bacterial toxin as a novel anti-cancer drug modulating the tumor-microenvironment

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  DOI: 10.1038/s41419-025-08219-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12669713/
Jun 2025
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Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

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1. scibot 25 Jun 2025
  
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  DOI: 10.1016/j.cub.2018.12.027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6370945/
52.53.155.43 52.53.155.43

miR-375 regulation of SSTR2 expression in corticotroph pituitary cells: somatostatin receptor ligands effects

2
1. scibot 18 Jun 2025
  
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  DOI: 10.1210/endocr/bqaf107
  
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  DOI: 10.1210/endocr/bqaf107
  
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52.53.155.43/9215a6848ed182cac9aecc8d782ba818a7adb6da/bqaf107-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic inhibition of PKCε attenuates neurodegeneration after global cerebral ischemia in male mice

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1. scibot 11 Jun 2025
  
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  DOI: 10.1002/jnr.24362
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147233/
May 2025
elifesciences.org elifesciences.org

ATP-release pannexin channels are gated by lysophospholipids

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.107067
  
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elifesciences.org/articles/107067
Apr 2025
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Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.008
  
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sciencedirect.com/science/article/pii/S2451945625000984
Mar 2025
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The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly

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1. scibot 23 Mar 2025
  
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  DOI: 10.1126/sciadv.adr5744
  
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science.org/doi/10.1126/sciadv.adr5744
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly

1
1. scibot 21 Mar 2025
  
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  DOI: 10.1126/sciadv.adr5744
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11922060/
www.cell.com www.cell.com

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

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1. scibot 05 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.005
  
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cell.com/immunity/fulltext/S1074-7613(25)00073-1
Feb 2025
journals.biologists.com journals.biologists.com

Akt is a mediator of artery specification during zebrafish development

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  DOI: 10.1242/dev.202727
  
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journals.biologists.com/dev/article/151/17/dev202727/361847/Akt-is-a-mediator-of-artery-specification-during
Sep 2024
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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.012
  
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sciencedirect.com/science/article/pii/S1550413124003644
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Generation of Rybp Homozygous Knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.scr.2019.101638
  
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sciencedirect.com/science/article/pii/S1873506119302685
Jun 2024
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De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency

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1. scibot 14 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109984
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells

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1. scibot 24 May 2024
  
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  DOI: 10.1186/s12885-024-12368-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11110260/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation

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  DOI: 10.1016/j.isci.2024.109357
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
Nov 2023
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Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway

1
1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.cub.2023.10.071
  
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sciencedirect.com/science/article/pii/S0960982223015099
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

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  DOI: 10.7554/eLife.84338
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10393046/
Jul 2023
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The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

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1. scibot 29 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112848
  
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sciencedirect.com/science/article/pii/S2211124723008598
Jun 2023
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Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition

1
1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112616
  
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sciencedirect.com/science/article/pii/S2211124723006277
aacrjournals.org aacrjournals.org

Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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1. scibot 03 Jun 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1577
  
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aacrjournals.org/cancerres/article/83/6/890/718574/Olig1-2-Expressing-Intermediate-Lineage
52.53.155.43 52.53.155.43

Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by ER Quality Controller Derlin-1 through Maintenance of Adult Neurogenesis

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1. scibot 01 Jun 2023
  
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  DOI: 10.1101/2023.04.27.538634
  
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52.53.155.43/8f97f68fa641b8fbd3a426ed1f879f227f19fe61/2023.04.27.538634v1.full-html.html
Mar 2023
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The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na+ channels

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  DOI: 10.1016/j.jbc.2023.104632
  
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sciencedirect.com/science/article/pii/S0021925823002740
onlinelibrary.wiley.com onlinelibrary.wiley.com

Neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/REST) controls spatial K+ buffering in primary cortical astrocytes

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1. scibot 03 Mar 2023
  
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  DOI: 10.1111/jnc.15755
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15755
Jan 2023
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PPARγ and C/EBPα response to acute cold stress in brown adipose tissue

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1. scibot 11 Jan 2023
  
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  DOI: 10.1016/j.isci.2022.105848
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9823219/
Dec 2022
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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  DOI: 10.1016/j.celrep.2022.111653
  
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sciencedirect.com/science/article/pii/S2211124722015248
Oct 2022
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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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1. scibot 20 Oct 2022
  
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  DOI: 10.1016/j.immuni.2022.09.014
  
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sciencedirect.com/science/article/pii/S1074761322005088
Mar 2022
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Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

1
1. scibot 09 Mar 2022
  
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  DOI: 10.1016/j.isci.2022.103912
  
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sciencedirect.com/science/article/pii/S2589004222001821
elifesciences.org elifesciences.org

Pathway-specific effects of ADSL deficiency on neurodevelopment

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1. scibot 04 Mar 2022
  
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  DOI: 10.7554/eLife.70518
  
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elifesciences.org/articles/70518
Feb 2022
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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

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1. scibot 02 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110320
  
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sciencedirect.com/science/article/pii/S2211124722000316
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies

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1. scibot 28 Jan 2022
  
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  DOI: 10.3233/ADR-210050
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8764631/
Nov 2021
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mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons

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Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue

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ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

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An Autonomous Oscillation Times and Executes Centriole Biogenesis

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PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels

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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

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Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties

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Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS

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Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation

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Heterogeneity in VEGF Receptor-2 Mobility and Organization on the Endothelial Cell Surface Leads to Diverse Models of Activation by VEGF

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Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

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Insulin deficiency, but not resistance, exaggerates cognitive deficits in transgenic mice expressing human amyloid and tau proteins. Reversal by Exendin‐4 treatment

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Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition

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Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

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Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation

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Oxidative stress differentially induces tau dissociation from neuronal microtubules in neurites of neurons cultured from different regions of the embryonic Gallus domesticus brain

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LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

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Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

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The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

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A damaged DNA binding protein 2 mutation disrupting interaction with proliferating-cell nuclear antigen affects DNA repair and confers proliferation advantage

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TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

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Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

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A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity

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Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

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EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis

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Analysis of SUMO1-conjugation at synapses

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Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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Untitled document

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KChIP2 is a core transcriptional regulator of cardiac excitability

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Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

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Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

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Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses

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