206 Matching Annotations
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    Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer
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  3. Aug 2025
  4. 52.53.155.43 52.53.155.43
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    Single-cell clonal lineage tracing identifies the transcriptional program controlling the cell fate decisions by neoantigen-specific CD8+ T cells
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    biorxiv.org/content/10.1101/2025.08.13.670223v1
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    Evaluation of ferroptosis as a biomarker to predict treatment outcomes of cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12326525/
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    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
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    CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
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    In Situ Pro-Inflammatory Effects of Dazostinag Alone or With Chemotherapy Upon the Tumor Microenvironment of Patients With Head and Neck Squamous Cell Carcinoma
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  11. Jul 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Palmitate‐Induced Primary Rat Senescent Astrocytes Exhibit Higher Inflammatory Activity and a Distinct Transcriptomic Profile Compared to Reactive Astrocytes
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    PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression
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    High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target
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    Defining Non–small Cell Lung Cancer Tumor Microenvironment Changes at Primary and Acquired Immune Checkpoint Inhibitor Resistance Using Clinical and Real-World Data
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    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
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    elifesciences.org/articles/101369
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    CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells
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  20. Jun 2025
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    A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy
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  28. May 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clear-Cell Renal Cell Carcinoma Molecular Subtypes Differ by African and European Genetic Similarity
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    High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
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    Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory
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    DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
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    Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
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  36. Apr 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical and Translational Results from PORTER, a Multicohort Phase I Platform Trial of Combination Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
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    A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer
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    Phase 1/2 trial of XPO1 inhibitor selinexor plus docetaxel in previously treated, advanced KRAS mutant non-small cell lung cancer
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    Early Neutrophil Activation in Psoriatic Skin at Relapse Following Dead Sea Climatotherapy
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer
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  44. Mar 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study
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  46. elifesciences.org elifesciences.org
    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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    elifesciences.org/reviewed-preprints/101035
  47. Feb 2025
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia
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    Co-evolution of atypical BRAF and KRAS mutations in colorectal tumorigenesis
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    Effect of MisMatch repair deficiency on metastasis occurrence in a syngeneic mouse model
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    YAP1 suppression by ZDHHC7 is associated with ferroptosis resistance and poor prognosis in ovarian clear cell carcinoma
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    Evaluating the Base Excision Repair Inhibitor TRC102 and Temozolomide for Patients with Recurrent Glioblastoma in the Phase 2 Adult Brain Tumor Consortium Trial BERT
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    Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis
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    Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
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  56. Jan 2025
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia
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  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer
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  59. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
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    Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer
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  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nuclear respiratory factor-1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells
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  63. Dec 2024
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    BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
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    Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers
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  68. Nov 2024
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    HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections
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    DNAR-05. EXCEPTIONAL RESPONDERS TO BASE EXCISION REPAIR (BER) INHIBITION FOR RECURRENT GLIOBLASTOMA DISPLAY ENRICHMENT FOR DNA DAMAGE RESPONSE PATHWAYS: RNA SEQUENCING ANALYSIS FROM A MULTICENTER TRIAL
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability
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  74. Oct 2024
  75. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quiescence and aging of melanocyte stem cells and a novel association with PD-L1
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomarker analyses investigating disease biology and associations with outcomes in the JAVELIN Merkel 200 trial of avelumab in metastatic Merkel cell carcinoma
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  79. Sep 2024
  80. www.sciencedirect.com www.sciencedirect.com
    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407630/
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    Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring Characteristics of the Tumor Immune Microenvironment of Patients with HNSCC from Single-Cell Transcriptomics of Peripheral Blood
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    ncbi.nlm.nih.gov/pmc/articles/PMC11375407/
  86. Aug 2024
  87. www.sciencedirect.com www.sciencedirect.com
    Novel PAX3::MAML3 fusion identified in alveolar rhabdomyosarcoma, using DNA methylation profiling to expand the genetic spectrum of “fusion-positive” cases
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    sciencedirect.com/science/article/pii/S0893395224001741
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310746/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292192/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p300 KAT Regulates SOX10 Stability and Function in Human Melanoma
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  91. journals.lww.com journals.lww.com
    151 Exceptional Responders to Base Excision Repair (BER)... : Neurosurgery
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  92. Jul 2024
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma
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  94. www.cell.com www.cell.com
    Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine
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  201. May 2022
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    Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment
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    A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling
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  204. Apr 2022
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cells retrace a stepwise differentiation program during malignant progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7611766/
  206. Mar 2022
  207. aacrjournals.org aacrjournals.org
    Race-associated Molecular Changes in Gynecologic Malignancies
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    aacrjournals.org/cancerrescommun/article/2/2/99/681553/Race-associated-Molecular-Changes-in-Gynecologic
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nonsense-mediated RNA decay is a unique vulnerability of cancer cells harboring SF3B1 or U2AF1 mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC8416940/
  209. Feb 2022
  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
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    ncbi.nlm.nih.gov/pmc/articles/PMC8828877/
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast
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    ncbi.nlm.nih.gov/pmc/articles/PMC8349796/
  212. Jan 2022
  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8709578/
  214. Dec 2021
  215. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia-derived cues for maintenance of microglia identity
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    onlinelibrary.wiley.com/doi/10.1002/glia.24136
  216. Nov 2021
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    Multi-tumor analysis of cancer-stroma interactomes of patient-derived xenografts unveils the unique homeostatic process in renal cell carcinomas
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  218. Oct 2021
  219. www.nature.com www.nature.com
    Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood
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    nature.com/articles/s41525-021-00248-y
  220. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms
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    clincancerres.aacrjournals.org/content/27/15/4265
  221. Sep 2021
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs
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    ncbi.nlm.nih.gov/pmc/articles/PMC8394524/
  223. www.sciencedirect.com www.sciencedirect.com
    Transcriptional control of brain tumor stem cells by a carbohydrate binding protein
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  224. Aug 2021
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    Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity
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  226. Jul 2021
  227. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Multiscale Network Analysis Reveals Molecular Mechanisms and Key Regulators of the Tumor Microenvironment in Gastric Cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32643
  228. www.nature.com www.nature.com
    Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
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  229. www.embopress.org www.embopress.org
    Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2
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    embopress.org/doi/full/10.15252/embr.201947845
  230. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation
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  231. www.embopress.org www.embopress.org
    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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  232. www.nature.com www.nature.com
    A chemical toolbox for the study of bromodomains and epigenetic signaling
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  233. Jun 2021
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    Type I interferon decreases macrophage energy metabolism during mycobacterial infection
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  235. May 2021
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    Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
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  237. Apr 2021
  238. www.sciencedirect.com www.sciencedirect.com
    Immunogenomic Landscape of Hematological Malignancies
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    sciencedirect.com/science/article/pii/S1535610820302750
  239. Mar 2021
  240. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models
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  241. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Ketogenic Diet Differentially Affects Neuron And Astrocyte Transcription
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15313
  242. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model
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  243. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Five Immune-Related lncRNA Signature as a Prognostic Target for Glioblastoma
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  244. Feb 2021
  245. www.sciencedirect.com www.sciencedirect.com
    LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability
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    sciencedirect.com/science/article/pii/S2211124719317103
  246. www.sciencedirect.com www.sciencedirect.com
    Unique signatures of stress-induced senescent human astrocytes
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  247. Jan 2021
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    Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
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