29 Matching Annotations
  1. Apr 2017
    1. Common symptoms are cellulites, swelling, redness, tenderness & discharge at the infected site, regional lymphadenopathy, chills, fever, high level of leukocyte & neutrophil.
    2. High dose of penicillin is the common cure. As an alternative tetracycline & chloramphenicol is used in beta-lactam intolerant patients.
    3. Isolation of Pasteurella multocida bacteria is usually done in sterile location such as the blood, pus or CSF.
    1. typically appearing within 24 hours following a bite

      Ask about the onset of the symptoms from last contact with animal.

    2. humans is often associated with an animal bite, scratch, or lick

      Can ask about animal contact.

    3. gram-negative

      we can stain the bacteria with a swab of the infected area

    4. cellulitis, abscesses, tenosynovitis, osteomyelitis, and septic arthritis. [1] The latter two are particularly common following cat bites because of their small, sharp, penetrative teeth

      Ask if they have any of these signs/symptoms. This can narrow down if they recieved the agent via a cat.

    1. thoroughly cleaned and debrided

      Was wound cleaned after bite/scratch?

    2. Animals do not have to be ill to pass the bacterium to humans, as they can carry the organism without showing symptoms.

      Has pt been bitten or scratched by an animal, even if animal has not appeared ill?

    3. develop into a serious soft tissue infection, and can also be complicated by abscesses, septic arthritis and osteomyelitis. Pasteurella spp can also cause meningitis, ocular infections, and respiratory infections, usually in patients with underlying pulmonary disease.

      What are the pt's signs and symptoms? Obvious skin differences near location of bite/scratch? Difficulty moving near injury? Neck pain? Difficulty breathing?

    4. P. multocida is found worldwide

      Location of pt and/or animal may not be telling for a pasteurella infection

    5. caused by infection with bacteria of the Pasteurella genus

      Bacterial infection - consider types of antibiotics that would be effective

    6. zoonotic disease

      Contracted from animals

      "Were you bitten or scratched by an animal recently?"

    1. respiratory tract and cause sinusitis and ear infections, and more severe symptoms including pneumonia or lung abscesses in those with underlying pulmonary disease, however this is rare. Other uncommon presentations of P. multocida infection include septicaemia (blood poisoning), eye infections, meningitis and gastrointestinal problems

      Serious complications spread to signs and symptoms in the respiratory tract, blood, meninges, etc.

    2. Exposure to aerosols, bites or scratches involving animals or injuries from objects contaminated with body fluids from animals require immediate first aid and medical attention

      Less likely, but infection can also occur from contact with infected animal bodily fluid, such as contact with infected object

    3. seek medical attention as soon as possible

      How long ago did the injury/infection occur?

    4. abscesses, cellulitis (an area of spreading inflammation) and joint infections

      Most common complications stay near the site of infection

    5. abscesses, cellulitis (an area of spreading inflammation) and joint infections

      What does the wound look like in the pt?

    6. local wound infection

      Typical presentation

    7. persons with a weakened immune system are at higher risk

      Does the pt have a weakened immune symptom?

    1. The genus Pasteurella is a member of the Pasteurellaceae family, which includes a large and diverse group of Gram-negative Gammaproteobacteria, whose members are not only human or animal commensals and/or opportunistic pathogens but also outright pathogens
    2. Most likely due to routine prompt prophylactic treatment of animal bite wounds with antibiotics, pasteurellosis is still a relatively uncommon cause of mortality in humans (37, 38), even though deaths due to pasteurellosis have increased in recent years in the United States (Fig. 1). Nevertheless, pasteurellosis is often associated with significant morbidity due to complications resulting from animal bite or scratch wounds or from respiratory exposure

      @SCUMedMicroS17

    3. conventional methods for detection and diagnosis of infection with Pasteurella (pasteurellosis) relied on observation of the bacterium by microscopy using staining and/or isolation by in vitro culturing on selective media, followed by phenotypic and/or serological characterization
    1. Page 138 has a lot of important info about symptoms. Warmth, swelling, sensitivity. Most from cat bites

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    1. The overall mortality rate was 31%

      Yikes :(

    2. In 5/13 cases a recent animal-derived trauma could be found. In the other cases the source of the infecting organism was thought to be endogenous (from patients’ own pharyngeal commensal flora) or secondary to contact with secretions of a pet animal.

      Contact with animals?

    3. All the patients had an underlying disease (77 % had cirrhosis) and 2 were receiving chemotherapy for hematologic malignancy.

      Did the patient have any illnesses before this?