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  1. Jun 2021
  2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Diuretic effects, pharmacokinetics, and safety of a new centrally acting kappa-opioid agonist (CI-977) in humans
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    1. Drugs_and_Ethics 15 Jun 2021
      Individual elimination half-life values ranged from 0.6 to 3.3 hours and were independent of dose.

      This could potentially be explained due to variation in Tmax. That is to say, it may not be that half life varies dramatically. Rather, absorption into the bloodstream after intramuscular injection may be the cause. I'm no expert on IM injections.

      enadoline KOR human
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    pubmed.ncbi.nlm.nih.gov/7876406/