1 Matching Annotations
- Nov 2020
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www-nature-com.ezproxy.rice.edu www-nature-com.ezproxy.rice.edu
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IS186-mediated integration of the plasmid into the chromosome or deletion of these accessory genes from an evolved plasmid that remained capable of self-replication conferred greater fitness benefits than SP formation
Can we say this is because of the combined fitness benefit
- by avoiding maintenance of a plasmid and
- lower expression of proteins?
Especially considering that there is expression of the accessory genes (ex: GFP in fig.2e)-> so the protein level fitness burden still exists, albeit at a lower extent.
How much of this burden is attributed to keeping a plasmid around?, maybe this could be tested with a low copy pSC101 type plasmid or by deleting all the accessory genes and repeating the evolution experiment to specifically look for the integrants this time
- by avoiding maintenance of a plasmid and
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