394 Matching Annotations
  1. Nov 2024
  2. Oct 2024
  3. Jul 2024
    1. Case: patient MW

      Disease Assertion: UCD/OTCD

      Family Info: NA

      Case Presenting HPOs: NA

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: NA

      Supplemental Data: NA Notes: mutation might cause exon 8 kipping durring splicing.

      Variant: NM_000531.6: c.718-2A>G

      ClinVarID: 97303

      CAID: CA224761

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: patient #5, male, German Disease Assertion: UCD/OTCD

      Family Info: Family history of the disease, Variant found in mother of the patient

      Case Presenting HPOs: infantile onset (HP:0003593), oritic aciduria(HP:0003218), hyperammonemia(HP:0001987), hyperglutaminemia(HP:0003217), low plasma citrulline (HP:0003572)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: Liver tissues were used to extract RNA that was later used to synthesize cDNA. The products were compared to healthy controls in order to detect variants. gDNA, in order to determine the size of deletions in patient 3 and 4 , a set of intronic primers presumably flanking the deletions was used and specific primers allowed sequencing of exactly those critical regions(sequencing on paper). To estimate the relevance of the identified intronic variants in terms of their capability to induce splicing, we used a score developed by Shapiro and Senapathy. This splice score offers information about the usage of a certain splice site

      Supplemental Data: TABLE 1, Notes: died at 11 months, was given medication and low protein diet and was asymptomatic during that time. Died from sever cerebral edema.

      Variant: NM_000531.6: c.1005+1091C>G

      ClinVarID: N/A

      CAID: CA2695233334

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    2. Case: patient #1, male, turkish

      Disease Assertion: UCD/OTCD

      Family Info: Family history of the disease, Variant found in mother of the patient

      Case Presenting HPOs: infantile onset (HP:0003593), coma(HP:0001259), episodic hyperammonemia(HP:0001951), oriticaciduria(HP:0003218)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: Liver tissues were used to extract RNA that was later used to synthesize cDNA. The products were compared to healthy controls in order to detect variants. gDNA, in order to determine the size of deletions in patient 3 and 4 , a set of intronic primers presumably flanking the deletions was used and specific primers allowed sequencing of exactly those critical regions(sequencing on paper). To estimate the relevance of the identified intronic variants in terms of their capability to induce splicing, we used a score developed by Shapiro and Senapathy. This splice score offers information about the usage of a certain splice site

      Supplemental Data: TABLE 1, Notes: very mild movement disorder, the diagnosis was prenatal so measures were taken from birth,. 2 biopsies were performed and the revealed respectively a 30% and 50 % decrease on OTC activity.

      Variant: NM_000531.6: c.867+1126A>G

      ClinVarID: 571311

      CAID: CA891843643

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: no patient ID#, male

      Disease Assertion: UCD/OTCD

      Family Info: N/A

      Case Presenting HPOs: Neonatal onset (HP:0003623)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: GDNA was extracted from blood or liver tissues using salt and ethanol precipitation. multiplex amplification for exons 1, 5 and 9 to screen male patients with large deletions. Band intensities were measured using a molecular dynamics phosphoimager.

      Supplemental Data: TABLE 2

      Variant: NM_000531.6: c.541-2A>G

      ClinVarID: 97243

      CAID: CA224675

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    2. Case: no patient ID#, male

      Disease Assertion: UCD/OTCD

      Family Info:

      Case Presenting HPOs: Neonatal onset (HP:0003623)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: GDNA was extracted from blood or liver tissues using salt and ethanol precipitation. multiplex amplification for exons 1, 5 and 9 to screen male patients with large deletions. Band intensities were measured using a molecular dynamics phosphoimager.

      Supplemental Data: TABLE 2,

      Variant: NM_000531.6: c.437C>G(p.Ser146*)

      ClinVarID: 97201

      CAID: CA224606

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: no patient ID, male

      Disease Assertion: UCD/OTCD

      Family Info: N/A

      Case Presenting HPOs: HP:0003623, HP: 0001987

      Case HPO FreeText: Neonatal onset, hyperammonemia

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: "Genomic DNAs were extracted from leukocytes, The ten exons and intron-exon boundaries of the OTC gene were PCR amplified and analyzed by Sanger sequencing on an ABI3100 sequencer. Intragenic deletions/duplications were searched for by Multiple Ligation Probe Dependent Amplification assay. Potential impact of non truncating variants on mRNA and protein was predicted using Splice Site Prediction. OTC variants were split into two groups, “severe” and “mild,” based on their impact on the clinical phenotype and on the OTC protein.

      Supplemental Data: Table 3, All nuclear family members were tested but no information about their genotype. the condition to be part of this study was the presence of at least one heterozygous female in the pedigree of the patient.

      Variant: NM_000531.6:c.217-2A>G(IVS2)

      ClinVarID: 915470

      CAID: CA412716751

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: Patient #30, female, Korean

      DiseaseAssertion: UCD/OTCD

      FamilyInfo: N/A

      CasePresentingHPOs: HP:0011463, HP:0003218

      CaseHPOFreeText: childhood onset, oroticaciduria,

      CaseNOTHPOs:

      CaseNOTHPOFreeText:

      CasePreviousTesting: "Potential impact of mutations on OTC function and/or folding assessed by multiple alignments of orthologous protein sequences and human OTC and structural data from Protein Data Bank (1C9Y and available orthologs). In M patients, the approximate extent of the deletions assessed by inspection of presence/absence of PCR products. In F patients, the deletions determined by the SALSA multiplex ligation probe amplification (MLPA) KIT P079 OTC (MRC-Holland, Amsterdam, the Netherlands) and the Affymetrix Human SNP 6.0 array (Santa Clara, CA). Sequence spanning 38,211,736 – 38,300,703 bp region on chromosome X (GRCh37) and including OTC was scanned for motifs CCTCCCT, CCTCCTT, CCTCCCTT, CCCCACCCC, CCNCCNTNNCCNC, GGNGGNAGGG and their complements known as being associated with recombination hotspots. Repeats capable of non-B DNA structure formation implicated in double strand breaks (DSBs) were sought by complexity analysis . X-inactivation ratio determined by analysis of methylation status of the human androgen-receptor locus (HUMARA)

      Supplemental Data: Table 1&2, Serum Gln+Glu was considered elevated, the minimum plasma ammonia, orotic acid and Gln+Glu concentrations depends on certain age range: Plasma ammonia: neonates <90μmol/l, other <60μmol/l. Urinary orotic acid: 0–1year <6.6mmol/mol creatinine, 1 – 10 years <3.5 mmol/mol creatinine, over 10 years <2.4 mmol/mol creatinine. Serum glutamate + glutamine: 0 – 1 month 200–1200μmol/l, 1 month–1year 200–1100μmol/l, 1year–18years 200–900μmol/l, over 18years 200–800μmol/l.

      Variant: NM_000531.6:c.491C>G(p.Ser164*)

      ClinVarID: 97220

      CAID: CA224642

      gnomAD:

      GeneName: OTC (ornithine transcarbamylase)

  4. May 2024
    1. His interest in the human psyche, past and present, led him to study mythology, alchemy, oriental religions and philosophies, and traditional peoples. Later he became interested in parapsychology and the occult.

      Fascinating, Carl Jung was into the occult.

  5. Apr 2024
  6. Feb 2024
    1. to be taken from that environment and put in an institution where there’s nothing but punishment and threats and punishment and more threats. So to me, that’s very damaging. So. That’s it.

      Ways of loving and parenting children were lost to countless family lines as a result of residential schools. Without proper love, care, attention and teaching, children grew into adults who didn't know how else to raise their own children besides what they picked up from the people who ran the schools. From there, trauma continues on through generations.

    2. You get whacked in the head in front of your peers in the classroom – that you’re stupid.

      Shame is a huge feature of residential schools that come to my mind. School officials relentlessly treated Indigenous children poorly, and attacked them if they did not behave or perform in a manner that was acceptable to them. Right at the start from entering the school, then having their belongings taken away, to being forbidden from speaking their language or practicing their culture, to having to pray for parents back home because they were “sinners,” as Elsie Paul had said, were all ways of making the children feel ashamed of who they are.

  7. Jan 2024
    1. The government isolated the people. Took away the lands and put people on reserves: “You stay there. You are not to go beyond this line. You are not to go into the white community.”

      This makes me think about who enforced these laws and the methods used to maintain this. The pass and permit system, not legislated by the Indian Act, held people on the reserves and prevented people from moving around like many families and communities had before settler colonial powers took over and enforced their regulations on Indigenous society.

    1. In 1941, he published "Wells, Hitler and the World State," in which he argued that Germany hewed much closer to a well-run society in which everyone thinks similarly and along scientific lines than England ever has. But it was run by a "criminal lunatic," so that didn't work out quite as Wells thought it would. Orwell also noted that patriotism, which Wells thought of as civilization-destroying, was the primary force inducing Russians and Britons to fight against Hitler.

      first referent "he" is George Orwell

      Example of a time in which patriotism and nationalism may have been beneficial.

    2. "In transport, we have progressed from coaches and horses by way of trains to electric traction, motor-cars, and aeroplanes. In mental organization, we have simply multiplied our coaches and horses and livery stables."

      from World Brain, double check with source

  8. Dec 2023
    1. Wells attempts in this essay to help mankind "pull it's mind together" for the betterment of people and the planet. How is this supposed to happen in a modern media environment which is designed to pull our minds apart as rapidly as possible?

      How might the strength of capitalism be leveraged to push people back toward a common middle rather than split them apart?

    2. Adler & Hutchinson's Great Books of the Western World was an encyclopedia-based attempt to focus society on a shared history as their common ground. H. G. Wells in his World Encyclopedia thesis attempts to forge a new "moving" common ground based on newly evolving knowledge based on distilling truth out of science. Shared history is obviously much easier to dispense and spread about compared to constantly keeping a growing population up to date with the forefront of science.

      How could one carefully compose and juxtapose the two to have a stronger combined effect?

      How could one distribute the effects evenly?

      What does the statistical mechanics for knowledge management look like at the level of societies and nations?

      link to https://hypothes.is/a/abTT1KPDEe6nqxPx4fXggw

    3. I dislike isolated events anddisconnected details. I really hate state-ments, views, prejudices, and beliefsthat jump at you suddenly out of mid-air.

      Wells would really hate social media, which he seems to have perfectly defined with this statement.

    4. without a World En-cyclopedia to hold men's minds togetherin something like a common interpreta-tion of reality there is no hope whateverof anything but an accidental and transi-tory alleviation to any of our world trou-bles. As mankind is so it will remainuntil it pulls its mind together. And if itdoes not pull its mind together then I donot see how it can help but decline.Never was a living species more peril-ously poised than ours at the presenttime. If it does not take thoughtto endits present mental indecisiveness catastro-phe lies ahead. Our species may yet endits strange eventful history as just the last,the cleverest, of the great apes. Thegreat ape that was clever-but not cleverenough. It could escape from mostthings but not from its own mental con-fusion.
    5. I believe thatin some such way as I have sketched, themental forces now largely and regrettablyscattered and immobilized in the univer-sities, the learned societies, research in-stitutions, and technical workers of theworld could be drawn together into areal directive world intelligence, and bythat mere linking and implementing ofwhat is known, human life as a wholecould be made much surer, stronger,bolder, and happier than it has ever beenup to the present time.
    6. My impression is that human brains arevery much of a pattern, that under thesame conditions they react in the sameway, and that were it not for tradition,upbringing, accidents of circumstance,and particularly of accidental individualobsessions, we should find ourselves-since we all face the same universe-muchmore in agreement than is superficiallyapparent. We speak different languagesand dialects of thought and can even attimes catch ourselves flatly contradictingone another in words while we are doingour utmost to express the same idea.How often do we see men misrepresent-ing one another in order to exaggerate adifference and secure the gratification ofan argumentative victory!

      We're far more alike than we imagine says Wells. Most of our difference is nitpicking for the sake of argument itself rather than actual meaning.

    7. They don't want their intimate convic-tions turned over and examined, and itis unfortunate that the emphasis put

      upon minor differences by men of science and belief in their strenuous search for the completest truth and the exactest expression sometimes gives color to this sort of misunderstanding.

      This emphasis on minor differences is exactly what many anti-science critics have done. See examples with respect to evolution and climate science denial.

    8. This Wo;Id Encyclopedia would bethe mental background of every intelli-gent man in the world.

      Who, here, defines intelligence?

      How would comparative anthropology between societies view such an effort? Would all societies support such an endeavor?

    9. very carefully assem-bled with the approval of outstandingauthorities in each subject, carefully col-lated and edited, and critically presented.It would be not a miscellany but a con-centration, a clarification and a synthesis.

      Compare this with Hutchins and Adler's solution undertaken just a few years following this beginning in the early 1940s and finally published in 1952: The Great Books of the Western World.

      These books speak toward the idea of living well and understanding mankind, but don't have the same deeply edited and critical synthesis viewpoint.

    10. It is science and not men of sciencethat we want to enlighten and animateour politics and rule the world.
    11. Can scientific knowledge and specializedthought be brought into more effectiverelation to general affairs?
    12. There is no dignityyet in human history. It would be purecomedy if it were not so often tragic, 'sofrequently dismal, generally dishonora-ble, and occasionally quite horrible.
    1. Wells, H. G. “A Galaxy of Authority.” Harper’s Magazine, December 2023. https://harpers.org/archive/2023/12/a-galaxy-of-authority/

      Read on 2023-12-25 at 12:39 pm in paper format. This is a painfully foreshortened version of the 11 page 1936/37 article.

      See also notes at https://hypothes.is/a/8WtRpKOMEe6M63_J8qxz3g

    1. In his ideas for a "mental clearing house" Wells was probably influenced by "Die Brucke" and its Goals for a World Information Clearing House.
    2. Wells believed that technological advances such as microfilm could be utilized towards this end so that "any student, in any part of the world, would be able to sit with his projector in his own study at his or her convenience to examine any book, any document, in an exact replica" (p. 54).

      This sounds a lot like Vannevar Bush's Memex, n'cest pas?

  9. ivanov-petrov.livejournal.com ivanov-petrov.livejournal.com
    1. Важнейший предрассудок современного мировоззрения — это представление о духовном мире, как о такой же совокупности механизмов и законов их функционирования, как это имеет место в естественной науке.Это можно достаточно точно назвать духовным материализмом. Наука материалистична не потому, что она якобы признает примат материи над духом, а потому, что ей неведом дух. Она не видит то, что научная картина мира — это порождение духа, историческое по своей природе, и по той же природе вполне ограниченное. Она не видит, что возможно совершенно другое отношение к миру и к его источнику.
  10. Nov 2023
  11. Oct 2023
    1. The narrative technique owes a good deal to W. G. Sebald, who loved to ruminate on strange and troubling episodes from history, blurring the boundary between fact and fiction.

      Benjamín Labatut also falls into this genre.

  12. Sep 2023
    1. 1: Why Do We Need Something Different? Doi: https://doi.org/10.7551/mitpress/8179.003.0004 Open the PDF Link PDF for 1: Why Do We Need Something Different? in another window 2: Questioning the Foundations of Traditional Safety Engineering Doi: https://doi.org/10.7551/mitpress/8179.003.0005 Open the PDF Link PDF for 2: Questioning the Foundations of Traditional Safety Engineering in another window 3: Systems Theory and Its Relationship to Safety Doi: https://doi.org/10.7551/mitpress/8179.003.0006 Open the PDF Link PDF for 3: Systems Theory and Its Relationship to Safety in another window II: STAMP: An Accident Model Based On Systems Theory [ Opening ] Doi: https://doi.org/10.7551/mitpress/8179.003.0029 Open the PDF Link PDF for [ Opening ] in another window 4: A Systems-Theoretic View of Causality Doi: https://doi.org/10.7551/mitpress/8179.003.0008 Open the PDF Link PDF for 4: A Systems-Theoretic View of Causality in another window 5: A Friendly Fire Accident Doi: https://doi.org/10.7551/mitpress/8179.003.0009 Open the PDF Link PDF for 5: A Friendly Fire Accident in another window III: Using STAMP [ Opening ] Doi: https://doi.org/10.7551/mitpress/8179.003.0030 Open the PDF Link PDF for [ Opening ] in another window 6: Engineering and Operating Safer Systems Using STAMP Doi: https://doi.org/10.7551/mitpress/8179.003.0011 Open the PDF Link PDF for 6: Engineering and Operating Safer Systems Using STAMP in another window 7: Fundamentals Doi: https://doi.org/10.7551/mitpress/8179.003.0012 Open the PDF Link PDF for 7: Fundamentals in another window 8: STPA: A New Hazard Analysis Technique Doi: https://doi.org/10.7551/mitpress/8179.003.0013 Open the PDF Link PDF for 8: STPA: A New Hazard Analysis Technique in another window 9: Safety-Guided Design Doi: https://doi.org/10.7551/mitpress/8179.003.0014 Open the PDF Link PDF for 9: Safety-Guided Design in another window 10: Integrating Safety into System Engineering Doi: https://doi.org/10.7551/mitpress/8179.003.0015 Open the PDF Link PDF for 10: Integrating Safety into System Engineering in another window 11: Analyzing Accidents and Incidents (CAST) Doi: https://doi.org/10.7551/mitpress/8179.003.0016 Open the PDF Link PDF for 11: Analyzing Accidents and Incidents (CAST) in another window 12: Controlling Safety during Operations Doi: https://doi.org/10.7551/mitpress/8179.003.0017 Open the PDF Link PDF for 12: Controlling Safety during Operations in another window 13: Managing Safety and the Safety Culture Doi: https://doi.org/10.7551/mitpress/8179.003.0018 Open the PDF Link PDF for 13: Managing Safety and the Safety Culture in another window 14: SUBSAFE: An Example of a Successful Safety Program Doi: https://doi.org/10.7551/mitpress/8179.003.0019 Open the PDF Link PDF for 14: SUBSAFE: An Example of a Successful Safety Program in another window Epilogue Doi: https://doi.org/10.7551/mitpress/8179.003.0020 Open the PDF Link PDF for Epilogue in another window Appendixes A: Definitions Doi: https://doi.org/10.7551/mitpress/8179.003.0022 Open the PDF Link PDF for A: Definitions in another window B: The Loss of a Satellite Doi: https://doi.org/10.7551/mitpress/8179.003.0023 Open the PDF Link PDF for B: The Loss of a Satellite in another window C: A Bacterial Contamination of a Public Water Supply Doi: https://doi.org/10.7551/mitpress/8179.003.0024 Open the PDF Link PDF for C: A Bacterial Contamination of a Public Water Supply in another window D: A Brief Introduction to System Dynamics Modeling Doi: https://doi.org/10.7551/mitpress/8179.003.0025 Open the PDF Link PDF for D: A Brief Introduction to System Dynamics Modeling in another window References Doi: https://doi.org/10.7551/mitpress/8179.003.0026 Open the PDF Link PDF for References in another window Index Doi: https://doi.org/10.7551/mitpress/8179.003.0027 Open the PDF Link PDF

      Great resources here

    1. Rượu vang 50 Anniversario – Minh chứng lịch sử cho sự kiêu hãnh và đam mê của nhà San Marzano

      Rượu vang 50 Anniversario – Minh chứng lịch sử cho sự kiêu hãnh và đam mê của nhà San Marzano

      Thông tin chi tiết về rượu vang 50 Anniversario San Marzano

      – Xuất xứ: Ý

      – Nhà sản xuất: San Marzano

      – Giống nho: Negroamaro, Primitivo

      – Nồng độ: 14.5%

      – Dung tích: 750ml

      – Quy cách: 6c/Thùng

      – Màu sắc: Đỏ

  13. Aug 2023
    1. Rượu vang nho Macabeo

      Rượu vang từ giống nho Macabeo thường có màu vàng sáng và hương thơm từ hương trái cây như táo, lê và cam đến hương hoa quả nhẹ nhàng và mùi thảo mộc. Macabeo thường có cấu trúc axit tương đối cao và độ axit cân đối, giúp cho rượu vang có khả năng thăng hoa và phù hợp để thưởng thức trẻ.

      Macabeo thường được sử dụng trong sản xuất rượu vang Cava, một loại rượu vang sủi bọt của Tây Ban Nha, cũng như trong việc tạo ra các loại rượu vang trắng khác. Macabeo mang trong mình sự cân đối và đa dạng của ngành sản xuất rượu vang Tây Ban Nha và đóng góp vào sự phong phú của các loại rượu vang trắng.

  14. Jun 2023
    1. Drawing on Carey Nieuwhof's decades of leadership, it shows how to sync your time, energy, and priorities so that you can reach your goals, have more energy for what you love, and begin to thrive both at work and at home

      Interest to me

    1. un allarme aereo

      Air raid sirens were a common occurrence in Monowitz from the summer of 1944. Air raids gave prisoners a chance to escape, to meet and speak to fellow prisoners, to steal food, to gain some respite from their labours and the torment of the Kapos. Some prisoners welcomed the air raids as a sign that the Third Reich was obviously nearing its end. The air raids also frightened their tormentors, the SS guards.

      There were large scale air attacks by the US Air Force against the I. G. Farben synthetic oil plant in Monowitz on 20 August, 3 September, 18 December and 26 December 1944, and on 19 January 1945, the day after the beginning of the evacuation of the camp. During the raid of 20 August, seventy-five prisoners were killed and a hundred and fifty injured; on 3 September, three hundred people, including SS and prisoners, were killed or injured. The high number of prisoner casualties was in part due to I. G. Farben employees forbidding prisoners to take cover in makeshift shelters.

      CM

      Subcamps of Auschwitz project

    2. Passò una SS in bicicletta

      This sentence suggests Sunday afternoon bicycle rides and walks with family in bourgeois pre-war Germany. Levi’s subsequent use of the SS man’s first name in the next sentence (‘È Rudi’) also suggests a relatively relaxed atmosphere, as if Levi sees a friend on that Sunday afternoon ride or walk.

      The picture painted of a quant Sunday afternoon bicycle ride is highly ironic. By 1943, Germany was struggling to keep its armed forces and economy operating. There was a serious lack of fuel for the vehicles of the Wehrmacht and the factories of the Third Reich. Resort was made to the use of the horse and bicycle for transport, wood gas for powering automobiles, and, above all, there was rationing. Synthetic oil production was seen as an alternative to overcome the lack of access to natural resources, including oil. I. G. Farben, the giant German chemical conglomerate, took the decision in 1941 to build a synthetic oil plant at the village of Monowitz, near Auschwitz, utilising the slave labour from the Auschwitz camps and the local abundance of coal and water. As the war progressed and the fuel shortage worsened, the importance of the synthetic oil plant at Auschwitz surged. This was visible in the increasing number of Auschwitz prisoners assigned to work at the I. G. Farben plant, and the creation of a Monowitz sub camp of Auschwitz in 1942 and, subsequently, an independent camp, Auschwitz III–Monowitz in 1943. By 1944, ten thousand Auschwitz prisoners were housed at the concentration camp Auschwitz III–Monowitz, working solely for I. G. Farben.

      ‘Rudi’ is riding his bike as there is little petrol for vehicles, even for the SS and the concentration camps, and even at the plant supposedly producing synthetic oil.

      CM

      Subcamps of Auschwitz project

  15. Apr 2023
  16. Mar 2023
    1. Ollendorff's name is used as an epithet in H.G. Wells' The Island of Doctor Moreau:[10] "Yesterday he bled and wept," said the Satyr. "You never bleed nor weep. The Master does not bleed or weep." "Ollendorffian beggar!" said Montgomery, "you'll bleed and weep if you don't look out!"
    1. Что такое мысль, мышление? В этом вопросе иногда возникает путаница, поскольку мыслью называют все проявления интеллектуальных способностей. Т.е. любое думание, любую внутреннюю речь называют мыслью. В таком случае мысль свободна в той же мере, как движения больного ДЦП, иначе говоря, там хаос. Но у человека в принципе есть такая способность как мышление. Объяснить что такое мышление сложно в двух словах. Важно, что мышление у человека встречается (как говорил Г.П.) так же редко, как танцы у лошадей.): Мышление свободно, так как оно опирается только на свое собственное содержание. Другое дело, что человеку обычно сложно различить – когда он мыслит, а когда просто думает. Мышление связано с думанием, оно как бы выхватывает его смыслы и делает их своим содержанием – если, конечно, мышление происходит. Я знаю только один способ «держать» мышление – это наблюдение мышления, это очень сложный прием – мыслить и одновременно наблюдать мышление, но он возможен, потому что мышление мы осуществляем полностью сами. Мыслит не голова, не мозг – мыслит «Я», поэтому мышление прозрачно для наблюдения, в нем нет скрытого (как, например, в вещах). Но наблюдение мышления – это способность, которая требует  очень большой тренировки. Нормальный человек может наблюдать только такое мышление, которое происходит очень медленно и последовательно, по шажкам. Но тогда он получает замечательный опыт свободы и достоверности, доверия к мышлению. Если этого опыта нет, или он не осознан, то человек обычно не доверяет мышлению, для него более достоверно чувство.Еще одно важное свойство мышления – это то, что в мышлении люди могут иметь абсолютное взаимопонимание – очевидно, что мышление как говорят психологи «интерсубъективно». Поэтому в мышлении возможна полная свобода общения.
  17. pavel-g-m.livejournal.com pavel-g-m.livejournal.com
    1. Центральная идея философии свободы – это мышление, как фундамент всего развития человека и человечества. Именно это отличает антропософию от различных визионерских и авторитарных оккультных систем.Поэтому мне представляется необычайно важным при совместном обсуждении «Философии свободы» не просто составить себе общее представление о содержании этой книги, а работать над ней так, чтобы это соответствовало ее содержанию, а именно – это содержание нужно научиться делать предметом мышления, того мышления о котором пишет Штайнер в этой книге.Ограничиться обсуждением разных мнений, образов и ассоциаций которые возникают при чтении этой книги – это означает совсем не понять того, о чем там идет речь. Потому, что у каждого есть свои представления, мифы, образы того, что такое мышление, и очень легко впасть в иллюзию того, что именно об этом говорит Штайнер.Он сам пишет:«Не надо только смешивать две вещи: "обладание мысленными образами" и переработку мыслей посредством мышления. Мысленные образы могут вставать в душе подобно сновидениям или как смутные внушения. Но это не есть мышление»
  18. pavel-g-m.livejournal.com pavel-g-m.livejournal.com
    1. Истина, позаимствованная от другого скептиком, который с этого момента стал верующим, не обладает духовными свойствами истины, родившейся в размышлении. Это истина внешняя и застывшая. Она приобретает влияние на человека, но неспособна проникнуть в самую глубину его существа, составить с ним одно целое. Живой является только та истина, которая порождена мышлением
    2. Семена скептицизма пустили ростки. В самом деле, современный человек уже не имеет духовного доверия к самому себе. За самоуверенной внешностью он скрывает большую внутреннюю неуверенность. Несмотря на огромную производительность в материальной области, он в своем развитии остановился на уровне ребенка, так как оставил без употребления свою способность к мышлению. Когда-нибудь покажется непостижимым, что наше поколение, столь высоко проявившее себя научными открытиями и изобретениями, в духовном отношении могло пасть так низко, чтобы отказаться мыслить.
    3. Дух века навязывает современному человеку скептическое отношение к его собственному мышлению, чтобы сделать его восприимчивым к истинам, которые он получает из авторитетных источников. Всем этим постоянным влияниям человек не может оказать должного сопротивления, так как он представляет собой сверхзанятое и разбросанное существо, у которого нет сил сосредоточиться. Более того, многообразная материальная зависимость влияет на его умственные способности таким образом, что в конце концов он теряет веру в право иметь собственные мысли.
    1. Iggers, Georg G. “Historiography in the Twentieth Century.” History and Theory 44, no. 3 (October 2005): 469–76. https://doi.org/10.1111/j.1468-2303.2005.00337.x.

    Tags

    Annotators

  19. Feb 2023
    1. R. G. Collingwood’s critique of what hecalled ‘scissors and paste’ history – meaning both those who uncritically cited earlierworks, and the use of scissors and paste to cut apart sources on index cards
    1. Engineers from those groups formed the core of the Space Task Group (STG), NASA’s first official foray into space research, and Katherine, who had worked with many of them since coming to Langley, “came along with the program” as the NACA became NASA later that year. While not a member of the STG, she developed an interest in calculating trajectories of spacecraft and satellites.

      I loved that she had ambition, determination, and developed interests in the areas that she was curious about.

  20. ivanov-petrov.livejournal.com ivanov-petrov.livejournal.com
    1. «Согласно онтологии коллективной мыследеятельности отдельный человек не обладает достаточной энергией для развития; для этого он должен рассматриваться в качестве компонента более сложных, коллективно-коммуникативных, кооперативных систем и процессов. Коллективная мыследеятельность и есть та минимальная онтологическая единица, по отношению к которой может быть поставлен вопрос об индивидуальном развитии и самоопределении. Коллективная мыследеятельность полагается как синхронизированный комплекс пяти процессов: мышления, понимания, действования, коммуникации и рефлексии»
  21. Nov 2022
    1. social historian G. M. Trevelyan (1978) put theissue some time ago, ‘Education...has produced a vast population able to readbut unable to distinguish what is worth reading.’
  22. Oct 2022
    1. another long forgotten manual for students, History and Historical Research (1928) by C.G. Crump of the Public Record Office: ‘Never make a note for future use in such a form ... that even you yourself will not know what it means, when you come across it some months later.’
    2. J.H. Plumb once showed me a set of Swift’s works given him by G.M. Trevelyan; it had originally belonged to Macaulay, who had drawn a line all the way down the margin of every page as he read it, no doubt committing the whole to memory.

      A line in the margin doesn't fit with any mnemotechniques I'm aware of, so it's more likely a method to indicate what he had read, and up to what point. Likely not an indicator of storage to memory.

  23. Sep 2022
    1. Maria Kozhevnikov, a neuroscientist at the National University of Singapore and Massachusetts General Hospital

      !- reference : Maria Kozhevnikov - neuroscientist at National University of Singapore, Massachusetts General Hospital - Nangchen tow, Amdo region of Tibet - testing if g-tummo vase breathing technique could raise core body temperature. One monk raised body temp to that normally associated with a fever - published results in PLOS One

    2. Russ Pariseau

      !- reference : Russ Pariseau - documentary filmmaker - made a film about Herbert Benson's research - Manil, Himachal, Pradesh, India - filmed g-tummo in a room with wet towels heated up in Manil

    3. Herbert Benson

      !- reference : Herbert Benson - Harvard Medical School - 1981 experiment's on Buddhist monks in Himalyas on research on g-tummo meditation published in Nature

  24. Aug 2022
  25. Jul 2022
  26. ivanov-petrov.livejournal.com ivanov-petrov.livejournal.com
    1. Хочу еще раз высказать, на мой взгляд, ключевой тезис о возможности духовного возрождения в современном мире: Для такого возрождение необходимо становление небольших сообществ, иначе говоря, рабочих групп, в которых будет строиться, развиваться возможность диалога, то есть взаимного понимания и участия в духовном и, в первую очередь, мыслительном общении, преодолевающем границы эгоцентризма его участников. Это принципиально не может быть общением, диалогом, в котором участники изначально согласны друг с другом. Наоборот, чем больше разнообразие и противоположность субъективных точек зрения и убеждений, тем более значимо усилие, направленное на возможность диалога. Христианская любовь состоит не в том, чтобы принимать близких по убеждениям, а в способности слышать Другого именно, как другого, а не как свое нарциссическое отражение. Только в этом случае диалог имеет общечеловеческое, а, точнее говоря, человечески духовное значение, а не значение для секты последователей одной идеологии. Только такая группа изначально воспроизводит и преодолевает современную разобщённость и нарциссический индивидуализм.
    1. Most academics continue to insist that it is still – barely – physically possible to limit warming to no more than 1.5°C. There are strong incentives to stay behind the invisible line that separates academia from wider social and political concerns, and so to not take a clear position about this.But we need to clearly acknowledge now that warming will exceed 1.5°C because we are losing vital reaction time by entertaining fantastic scenarios. The sooner we get real about our current situation and what it demands, the better.

      Slight chance. We need nonlinear solutions and to find all the leverage points, social tipping points and idling capacity we can.:

      Social tipping dynamics for stabilizing Earth’s climate by 2050 https://hyp.is/go?url=https%3A%2F%2Fwww.pnas.org%2Fdoi%2F10.1073%2Fpnas.1900577117&group=world

      An Introduction to PLAN E Grand Strategy for the Twenty-First-Century Era of Entangled Security and Hyperthreats https://hyp.is/go?url=https%3A%2F%2Fwww.usmcu.edu%2FOutreach%2FMarine-Corps-University-Press%2FExpeditions-with-MCUP-digital-journal%2FAn-Introduction-to-PLAN-E%2Ffbclid%2FIwAR3facE8l6Jk4Msc8C1nw8yWtwnzSCXVZGlO7JLkjqo8CWYTYAqAMTPkTO8%2F&group=world

      Science Driven Societal Transformation https://hyp.is/go?url=http%3A%2F%2Fdocdrop.org%2Fvideo%2Fz9ZCjd2rqGY%2F&group=world

    1. G Fund interest rate

      G-Fund's interest rate is calculated monthly, based on the average yield of all U.S. Treasury securities with 4 or more years to maturity.

  27. May 2022
    1. DICER1 syndrome is an autosomal-dominant, pleiotropic, tumor-predisposition disorder arising from pathogenic germline variants in DICER1, which encodes an endoribonuclease integral to processing microRNAs (1).

      Gene Name: DICER1 PMCID: PMC5443331 PMID: 28323992 HGNCID: not found Inheritance Pattern: autosomal dominant Disease Entity: thyroid cancer and familial multinodular doiter Mutation: germline loss-of-function mutation Zygosity: not provided Variant: c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with a DICER1 germline mutation and 135 controls from 48 families Case: family members used; both males and females used and no significant differences seen among sex; ages range from 20-40 with carriers being significantly younger than controls; no significant differences seen among ethnicity but participants located from the US, UK, and Great Britain CasePresentingHPOs: thyroid cancer or MNG diagnosis common to those with a DICER! mutation but with no chemotherapy or radiation treatment yet CasePreviousTesting: tested levels of thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin; thyroid palpation; thyroid ultrasound; Sanger or next-generation sequencing assays gnomAD: n/a Mutation Type: missense

  28. Apr 2022
    1. DICER1 Syndrome

      GeneName: DICER1 PMID: 28323992 PMCID: PMC5443331 *No HGNCID found Inheritance pattern: autosomal-dominant Disease Entity: multinodular goiter and thyroid cancer Mutation: Germline Zygosity: not listed Variant: c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with DICER1 germline mutations from 48 family controls (135 individuals) that lacked the DICER1 mutation Case: male and female carriers as well as family members were studied. Ages: 20, 30, and 40 for both populations (DICER1 carriers were significantly younger than controls}. Population from Great Britain, UK, and USA (no significant difference between race, ethnicity, or sex found). CasePresentingHPOs: no previous therapeutic radiation or chemotherapy. Thyroid cancer or MNG diagnoses were likely reported with the DICER1 mutation CasePreviousTesting: Sequencing performed with Sanger or next-generation sequencing assays. DICER1 carriers underwent testing to obtain thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin levels as well as medical history and physical examinations (+thyroid palpation). Participants were also given thyroid US examinations. gnomAD: n/a Mutation Type: missense

  29. Mar 2022
    1. En somme, les études sur la communication des élèves atteints d’autisme permettent de mettre en évidence l’importance d’un contexte riche en stimulations appropriées (sons et images), mais également une évidente « stabilité » de l’information à décoder, le suivi des émotions des personnages, le rôle de l’imitation dans les apprentissages. Ces résultats encouragent donc l’usage d’outils informatiques adéquats pour améliorer la communication sociale chez les enfants atteints d’autisme.

      L'association de deux sujets qui n'ont pas de corrélation vérifiéé, revient dans la conclusion en contradiction avec la conclusion de l'étude de Ramdoss, S et al.

    2. Nous allons montrer par une courte analyse de quelques études l’impact du travail éducatif informatisé dans l’apprentissage de la communication sociale chez des enfants atteints d’autisme.

      En contradiction avec l'hypothèse :

      Results suggest that CBI should not yet be considered a researched-based approach to teaching communication skills to individuals with ASD. However, CBI does seem a promising practice that warrants future research. Les résultats suggèrent que le CBI ne devrait pas encore être considéré comme un approche fondée sur la recherche pour enseigner les compétences en communication aux personnes ayant Troubles du Spectre Autistique. Cependant, le CBI semble être une pratique prometteuse qui justifie des recherches futures.

  30. Jan 2022
  31. ivanov-petrov.livejournal.com ivanov-petrov.livejournal.com
    1. На человеческом существовании порой лежит и отпечаток того, что можно, пожалуй, назвать отчаянием. Человек действует - читает, сердится, трудится, исследует, добивается чего-то, зарабатывает деньги - и в последнем отчаянии (иногда безотчетном) он говорит себе, что все это как целое не имеет никакого смысла и, если задается вопрос о смысле целого, то будет правильно заглушить его и отвергнуть как не имеющий ответа и потому бессмысленный". К. Ранер.https://pavel-g-m.livejournal.com/326947.html
    1. Treatment with single probiotic B. infantis didn't impact on abdominal pain, bloating/distention, or bowel habit satisfaction among IBS patients. However, patients who received composite probiotics containing B. infantis had significantly reduced abdominal pain
  32. Sep 2021
    1. This fundamental truth (expressed in economic notation as r > g, or "return on capital is greater than economic growth") means that "meritocracy" is a lie: the richest people in a market economy aren't the people who do the best work, it's the people who started off rich.

      Thomas Piketty's r > g shows that meritocracy is a lie in that the richest people aren't the ones that do the best or most productive work, but simply those who start of rich.

  33. Aug 2021
  34. Apr 2021
    1. A crucial difference between representations of relative error inthese equations compared withEquations 6and7 for the single-facet designs is that three sources of measurement error varianceare separately represented, withpt2ntequaling specific-factor error,po2noequaling transient error, andpto,e2ntnoequaling random-responseerror. Effects fortasks, occasions, and their interaction are includedin the denominator for the D-coefficient but not the G-coefficientbecause those effects can change the absolutemagnitude of scoresbut not their relative differences.
    1. procedural systems like computer software actually represent process with process. This is where the particular power of procedural authorship lies, in its native ability to depict processes.”4 That is, while print, film, and even forms of digital audio broadcasting can attempt to represent genders, sexualities, race, class, objects, and so forth, game worlds “represent process with process

      WHy does this even matter? You can respresent the same thing without process.

  35. Mar 2021
    1. In Georgia a barista from Athens would probably not fit in serving coffee in Americus.

      This is a very interesting and weirdly clear analogy.

      Venika G.

  36. Feb 2021
  37. Oct 2020
  38. Sep 2020
    1. It could create incentives for action by conditioning a portion of funds going to states in any future relief packages on states’ adherence to the measures

      Why did this not happen? I feel like it isn’t the federalist system in general that are failing us— it’s the leaders of the system. Why did congress not make a playbook and create incentives for states to follow them? This reminds me of how the drinking age became 21 in every state from the funding of the highways.

    2. Lacking strong federal leadership to guide a uniform response, the United States quickly fulfilled the World Health Organization’s prediction that it would become the new epicenter of Covid-19.

      I wonder if a democrat was in office when covid hit if we would have stronger federal leadership. Would we have been in a state of emergency if someone who believed in the facts of science wasn’t in office? I have trouble believing that there is nothing the president could have done to prevent covid from getting this out of hand.

  39. Aug 2019
    1. Function expressions and arrowsIn JavaScript, a function is not a “magical language structure”, but a special kind of value. The syntax that we used before is called a Function Declaration:

      JavaScript

    1. Coalition forces had called on the STC to withdraw from their positions in Aden or face further action. It said it launched its strike against a "threat" to the country's government.

      Aden port taken

    1. Omar's intentionOmar, who cast one of the 17 dissenting votes, countered with a resolution of her own, supporting the right to boycott foreign governments “to advocate for human rights abroad,” and likening the action to boycotts of Nazi Germany and the Soviet Union.

      Test2

  40. Jan 2019
    1. Coming back to the two ‘FreeSync’ settings in the monitor OSD, they differ in the variable refresh rate range that they support. ‘Standard Engine’ supports 90 – 144Hz (90 – 119Hz via HDMI) whilst ‘Ultimate Engine’ gives a broader variable refresh rate range of 70 – 144Hz (62 – 119Hz via HDMI). We didn’t notice any adverse effects when using ‘Ultimate Engine’, so we’d suggest users simply stick to that option.

      In my tests using Standard Engine, in combo with G-Sync Compatible Driver, I get more screen flickering during menus.

  41. Mar 2018
  42. Dec 2017
  43. Oct 2017
    1. , Fukuyama is in the position of favoring a democratic political order while arguing that the theories that first justified it, like universal rights and moral and epistemological individualism, were mistaken

      fukuyama favors the democratic political order but thinks the morals and ideals of the people who run it are wrong.

  44. Apr 2017
    1. This ability to focus one’s attention is essential for effective performance of many of life’s necessary and daily activities, such as acquiring and using selected information; making and carrying out plans; and self-regulation of responses and behavior to meet desired goals (Kaplan & Kaplan, 1982). Direct attention is, therefore, an important cognitive skill required on a daily basis for students processing multiple sources of information, and working towards their academic goals at universities.

      In contrast with the concept of "involuntary attention". Both types of attention utilize different sections of the brain and perform their tasks with incredible difference. Despite GSU students generally lacking a space to induce involuntary attention for rejuvination, I'd like to question and understand how our urban environment shapes the brains of our students differently than those with access to green spaces. How has prolonged direct attention created a difference in urban campus students compared to classic university students.

    2. Attention Restoration Theory

      defined as, "suggests that mental fatigue and concentration can be improved by time spent in, or looking at nature."

      Regardless of the parks avaliable to GSU students, none seem to specifically meet the standards set by Kaplan to maximize benefit: "-Extent (the scope to feel immersed in the environment)

      -Being away (providing an escape from habitual activities)

      -Soft fascination (aspects of the environment that capture attention effortlessly)

      -Compatibility (individuals must want to be exposed to, and appreciate, the environment"

      Immediatley avaliable green spaces within Atlanta hardly separate themselves from their own city envirlonment and meerly provide a small area recreational area rather than an escape. http://www.ecehh.org/research-projects/attention-restoration-theory-a-systematic-review/


      In relation to GSU's severe lack of student avaliable green space, "The natural world has previously been depicted as a restorative environment that replenishes ones resources and urban environments such as cityscapes have been seen to potentially reduce attentional capacity."

      https://positivepsychologyprogram.com/attention-restoration-theory-nature-lets-solve-problems/

    3. “natural scenery employs the mind without fatigue and yet exercises it; tranquilizes it and yet enlivens it; and thus through the influence of the mind over the body, gives the effect of refreshing rest and reinvigorating to the whole system

      This idea sums up the focus of this paper; the impact of natural spaces on the mind of students and how open green space revigorates mental fatigue. Many large closed campus schools (UGA, Georgia Tech, Berry, etc) feature the beauty and vigor of their campus' alongside their academic triumphs. The campus of a university must allow itself to create differentiated spaces based on necessities for relaxation versus work. Georgia State struggles with this concept by consistently immersing it's students within a bustling city life with fairly little down time.

    4. open spaces have not been systematically examined for their potential in replenishing cognitive functioning for attentional fatigued students

      What quality of open spaces replenishes cognitive function? How does this tie into Georgia States "cramped" campus?


      REVISION & RESPONSE: open, specifically natural, spaces replenish cognitive function by relaxing the brain and thought processes of a student. These spaces are less visually intensive than the typical information overload of a student's standard day. Georgia State, despite a severe lack of open space, does offer Hurt and Woodruff parks as alternative green areas to relax within. This lack of open space is an important issue within the built environment of GSU, as we lack a scientifically backed attribute of student success that most closed campus universities can offer.

    5. increased technology use within today’s multitasking society is likely to hijack a student’s attentional resource placing her/him at risk of underachieving academic learning goals and undermining success at a university

      Arguably bold claim; regardless of backing source for information, how do students perform on average with an explosion of technological progress over the past 20 years compared to before smartphones were widely popularized?

      Technology absolutely depletes student's "attentional resource", yet we see an increased trend in technological innovation within classroom spaces; is this setting students up for failure by providing distractions from their work?

      Technology has arguably also greatly enhanced the students ability to learn, share resources, and more accurately/timely locate information beneficial to their success rather than simply create distraction.

    6. . Today’s university must be resilient spaces in which the learning environment encompasses more than technology upgrades, classroom additions, and its academic buildings – in fact, the entire campus, including its open spaces, must be perceived as a holistic learning space that provides a holistic learning experience

      Does GSU conform to this standard? Is it necessary/true? How does GSU make up for a lack of "open spaces" utilizing it's built environment to establish a holistic learning space?


      Georiga State strays from Scholl/Gulwadi's ideals; establishing an interconnected learning environment through downtown Atlanta by creating a community of students who not only share like minded goals but also campus space together. Although the city lacks the natural relaxation nature can provide to alleviate stress, I believe students find solace in the student body culture of the university.

    1. Through lack of prac-tice and not having others who can speak it, I've lost most of the Paclmco tongue.

      As with signifyin(g), practice and the social interchange with others are crucial.

  45. Mar 2017
    1. Central Committee man

      Dignity and Gender both. A man is put in charge to maintain order. Also, even through all that they've been through they still choose to elect a person of power to maintain their dignity throughout the situation.

  46. Feb 2017
    1. increased technology use within today’s multitasking society is likely to hijack a student’s attentional resource placing her/him at risk of underachieving academic learning goals and undermining success at a university

      What role does technology play in the promotion or degradation of our learning and how does this tie in with how our attention is directed?


      Revision + Response: As technology becomes increasingly intertwined with all aspects of life, including education, concern should be raised as to how being consistently connected to an online space not only distracts us, but prevents natural attention rejuvination from students specifically, furthering levels of fatigue. As the evolution of education ties itself closer to technology and reliance on online spaces, it seems like the system is setting itself up for failure in the long run by breaking the division between educational spaces and natural/recreational ones.

    2. Learning is a lifelong and year-round pursuit, which takes place throughout the campus, not just fragmented indoors in designated instructional spaces

      This is extremely important to the general thesis of the piece and summarizes all the information before this statement well. How is learning facilitated outside of classrooms on campus? What creates a "holistic" learning space? How does a campus teach outside of it's classrooms?


      Revision + Response: A holistic learning space/experience details the entire daily process of a student's day, and their interactions in space between classrooms + nature. The process of learning expands beyond taking in information; internalizing ideas through natural experiences. Holistic learning experiences create a balance between work, extra curricular activities, and student social lives which allows them to continue education through an optimal, healthy process.

    3. we propose that the natural landscape of a university campus is an attentional learning resource for its students.

      Thesis statement of the piece. What is an "attentional learning resource"? What is a "natural landscape" How do these concepts interact with one another.


      Revision + Response: The natural landscape of a university refers to the "green space" of a campus and it's relationship with the buildings that surround it. The natural landscape being an attentional learning resource outlines how learning and attention are facilitated outside of a classroom; the greenspace of a campus rejuvinates the mind allowing for students to relax but also mentally prepares them to continue their learning experience with less fatigue. The natural landscape of a campus is integral to the continued learning experience of it's students as it subconciously decompiles stress/depression.

    4. Direct attention requires mental effort and cognitive control for an individual to sustain focus and prevent distracting stimuli from interfering with an intended activity

      Describes what I am currently struggling with

    5. Many university founders desired to create an ideal community that was a place apart, secluded from city distraction but still open to the larger community, enabling their students and faculty to devote unlimited time and attention for classical or divinity learning, personal growth, and free intellectual inquiry

      How does this relate to the "perfect" built environment for learning? How does GSU defy these standards? How does GSU refute this claim

    6. diverse and evolving needs

      What are those needs? In what ways are they "diverse" and "evolving"? This sentence assumes "holistic learning spaces" are "good." Here's a source that outlines a debate about "holistic education"

    1. The cook is Joe or Carl or Al, hot in a white coat and apron, beady sweat on white forehead, below the white cook's cap; moody, rarely speaking, looking up for a moment at each new entry. Wiping the griddle, slapping down the hamburger. He repeats Mae's orders gently, scrapes the griddle, wipes it down with burlap. Moody and silent. Mae is the contact, smiling, irritated, near to outbreak; smiling while her eyes look on past—unless for truck drivers.

      Although cooking is typically a female role, here we see the male taking on this job as it is the main function of the work place.

  47. Oct 2016
    1. direct and indirect attention and restoration

      What I am curious about is how indirect attention and restoration can be used to create new college campuses? What does that entail?

    2. One way to examine this potential is to consider the entire campus with its buildings, roads and natural open spaces as a well-networked landscape system that supports student learning experiences.

      I totally agree with this statement but how exactly are they going to do it?

    3. we propose that the natural landscape of a university campus is an attentional learning resource for its students.

      This sentence is consider the thesis statement. It talks about how the landscape of a university campus could effect the learning of a student. Which connects to the whole essay.

    4. permeable

      the word permeable means capable of being permeated : penetrable; especially : having pores or openings that permit liquids or gases to pass through according to the Marriam Webster dictionary