42 Matching Annotations
  1. Apr 2021
    1. "Given you acknowledged...in March 2020 that Asian countries were masking up at the time, saying we shouldn't mask up as well was a mistake, wasn't it... at the time, not just in hindsight?" My question to Dr Fauci. Listen to his very passionate response:
  2. Mar 2021
    1. Many European countries suspended use of AstraZeneca’s vaccine earlier this month following initial reports of the symptoms, which have led to at least 15 deaths. Most resumed vaccinations after the European Medicines Agency (EMA) recommended doing so on 18 March, saying the benefits of the vaccine outweigh any risks. EMA is continuing to investigate the matter and will convene a wide-ranging committee of experts on 29 March.
    1. SummaryBackgroundA new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against this variant.MethodsVolunteers (aged ≥18 years) who were enrolled in phase 2/3 vaccine efficacy studies in the UK, and who were randomly assigned (1:1) to receive ChAdOx1 nCoV-19 or a meningococcal conjugate control (MenACWY) vaccine, provided upper airway swabs on a weekly basis and also if they developed symptoms of COVID-19 disease (a cough, a fever of 37·8°C or higher, shortness of breath, anosmia, or ageusia). Swabs were tested by nucleic acid amplification test (NAAT) for SARS-CoV-2 and positive samples were sequenced through the COVID-19 Genomics UK consortium. Neutralising antibody responses were measured using a live-virus microneutralisation assay against the B.1.1.7 lineage and a canonical non-B.1.1.7 lineage (Victoria). The efficacy analysis included symptomatic COVID-19 in seronegative participants with a NAAT positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to vaccine received. Vaccine efficacy was calculated as 1 − relative risk (ChAdOx1 nCoV-19 vs MenACWY groups) derived from a robust Poisson regression model. This study is continuing and is registered with ClinicalTrials.gov, NCT04400838, and ISRCTN, 15281137.FindingsParticipants in efficacy cohorts were recruited between May 31 and Nov 13, 2020, and received booster doses between Aug 3 and Dec 30, 2020. Of 8534 participants in the primary efficacy cohort, 6636 (78%) were aged 18–55 years and 5065 (59%) were female. Between Oct 1, 2020, and Jan 14, 2021, 520 participants developed SARS-CoV-2 infection. 1466 NAAT positive nose and throat swabs were collected from these participants during the trial. Of these, 401 swabs from 311 participants were successfully sequenced. Laboratory virus neutralisation activity by vaccine-induced antibodies was lower against the B.1.1.7 variant than against the Victoria lineage (geometric mean ratio 8·9, 95% CI 7·2–11·0). Clinical vaccine efficacy against symptomatic NAAT positive infection was 70·4% (95% CI 43·6–84·5) for B.1.1.7 and 81·5% (67·9–89·4) for non-B.1.1.7 lineages.InterpretationChAdOx1 nCoV-19 showed reduced neutralisation activity against the B.1.1.7 variant compared with a non-B.1.1.7 variant in vitro, but the vaccine showed efficacy against the B.1.1.7 variant of SARS-CoV-2.
    1. After South Africa bought AstraZeneca vaccines from the Serum Institute of India, results from a small local study with only mild and moderate infections showed that the vaccine was not effective against the 501Y.V2 variant. South Africa sold its AstraZeneca vaccines in March despite World Health Organisation (WHO) advice that the jab should still be used in countries where new variants are circulating.Some experts, including the government’s ministerial advisory committee on vaccines, say the move is in line with South Africa’s evidence-based approach to COVID-19 decisions, while the Democratic Alliance and a group of scientists argue it’s a missed opportunity.
    1. Understanding COVID-19 is a 2-day course (April 20th and 21st) intended to provide interested high school students with exposure to concepts in biotechnology through the lens of the COVID-19 pandemic. Students will leave the course able to answer the following questions:
    1. This short video seeks to inform high school students about an opportunity to attend a 2 day virtual course April 20 and 21 entitled "COVID-19: Evolution of a Pandemic". In this course students will learn where the virus came from, how it causes disease, why viruses are existential threats to humanity, how treatments are discovered and how vaccines are made. In addition, we will discuss how policy and advocacy influence the course of pandemics, when life will get back to normal, and how worried we should be about future pandemics and what we can do now to prevent future pandemics.
    1. The risk of contagion is highest in indoor spaces but can be reduced by applying all available measures to combat infection via aerosols. Here is an overview of the likelihood of infection in three everyday scenarios, based on the safety measures used and the length of exposure
    1. New paper!!! @psmaldino look at what causes the persistence of poor methods in science, even when better methods are available. And we argue that interdisciplinary contact can lead better methods to spread. 1
    1. Today was a very, very odd day I testified before @senatehomeland They held a hearing on hydroxychloroquine. Yup, HCQ In the middle of the worst surge of pandemic HCQ It was clear how our information architecture shapes questions of science and medicine of COVID A thread
    1. alarmism vs denial in Switzerland...or some observations on the Swiss COVID response a monster thread...
    1. We will be stuck in an endless cycle of lockdown/release for next 18 months, if we do not start mass testing, tracing, & isolating those who are carriers of the virus while pursuing rapid research for antiviral treatment or vaccine. This is the message the public needs to hear.
    1. Conspiracy theories attempt to explain events as the secretive plots of powerful people. While conspiracy theories are not typically supported by evidence, this doesn’t stop them from blossoming. Conspiracy theories damage society in a number of ways. To help minimise these harmful effects, The Conspiracy Theory Handbook, by Stephan Lewandowsky and John Cook, explains why conspiracy theories are so popular, how to identify the traits of conspiratorial thinking, and what are effective response strategies.
    1. This paper presents a long-term study on how the public engage with discussions around citizen science and crowdsourcing topics. With progress in sensor technologies and IoT, our cities and neighbourhoods are increasingly sensed, measured and observed. While such data are often used to inform citizen science projects, it is still difficult to understand how citizens and communities discuss citizen science activities and engage with citizen science projects. Understanding these engagements in greater depth will provide citizen scientists, project owners, practitioners and the generic public with insights around how social media can be used to share citizen science related topics, particularly to help increase visibility, influence change and in general and raise awareness on topics. To the knowledge of the authors, this is the first large-scale study on understanding how such information is discussed on Twitter, particularly outside the scope of individual projects. The paper reports on the wide variety of topics (e.g., politics, news, ecological observations) being discussed on social media and a wide variety of network types and the varied roles played by users in sharing information in Twitter. Based on these findings, the paper highlights recommendations for stakeholders for engaging with citizen science topics.
    1. Collective Intelligence, co-published by SAGE and the Association for Computing Machinery (ACM), with the collaboration of Nesta, is a global, peer-reviewed, open-access journal that publishes trans-disciplinary work bearing on collective intelligence across the disciplines. The journal embraces a policy of creative rigor in the study of collective intelligence to facilitate the discovery of principles that apply across scales and new ways of harnessing the collective to improve social, ecological, and economic outcomes. In that spirit, the journal encourages a broad-minded approach to collective performance. We welcome perspectives that emphasize traditional views of intelligence as well as optimality, satisficing, robustness, adaptability, and wisdom. In more technical terms, this includes issues related to collective output quality and assessment, aggregation of information and related topics (e.g., network structure and dynamics, higher-order vs. pairwise interactions, spatial and temporal synchronization, diversity, etc.), accumulation of information by individuals/components, environmental complexity, evolutionary considerations, and design of systems and platforms fostering collective intelligence.
    1. This workshop will provide design researchers with an introductory assessment of the landscape of current options in terms of the CARES experience methodology
    1. Ein Pharmakonzern soll die Impfstoffentwicklung gegen das Coronavirus eingestellt haben, weil es besser wäre, infiziert zu werden und sein Immunsystem arbeiten zu lassen. Aber diese Behauptung stimmt nicht.
    1. The campaign against @DrZoeHyde that has involved several scientists targeting her with personal attacks, and trying to misrepresent her is deeply disappointing. She has been referred to as 'evil', 'idiotic', 'sadistic', and a'sociopath'. A few thoughts on these attacks.
    1. All-inclusive authorship on large scientific papers can a be dangerous practice Alert: potential unpopular opinion Thread 1/n
    1. I need to make some preliminary remarks on my report today. The EMS - which is where the positive test data comes from - seems to be having quite a problem. Many cases were reported later today. In Vienna there was according to this
    1. Spain’s health ministry will soon launch a WhatsApp interactive channel to fight against disinformation on COVID-19 vaccines, El País reported. This should help reduce the percentage of Spaniards who still refuse to get vaccinated. EURACTIV’s partner EuroEfe reports.
    1. On Facebook, videos of people reporting disturbing side effects from the shots have been viewed by millions. Fact-checking efforts can't keep up.
    1. China has been praised for its "vaccine diplomacy," promising shots to developing countries and investing in vaccine candidates that do not require expensive cold storage to be effective. But as questions have been raised over the effectiveness of one of those vaccines, the country's state media has reacted aggressively, targeting not just critics but also other vaccines, in an apparent effort to tear down their reputation in the name of defending the Chinese shots.
    1. As the world looks to the new covid-19 vaccines with hope, there are major worries about how social media will affect uptake. Claire Wardle and Eric Singerman ask what the companies in charge should be doing to stem the misinformation tide
    1.     Hungary has agreed to buy enough doses of Russia’s Sputnik V vaccine to inoculate 1 million people against coronavirus, becoming the first EU member to turn to Moscow after complaining about the pace of the bloc’s own vaccine procurement programme.
    1. Celebrities including comedians Romesh Ranganathan and Meera Syal and cricketer Moeen Ali have made a video urging people to get the Covid vaccine.
    1. #AskWHO​ series: This was the live discussion of 27 January 2021 about COVID-19 virus variants with Dr Mike Ryan, Executive Director of WHO Health Emergencies Programme, and Dr Maria Van Kerkhove, WHO Technical Lead on COVID-19. Questions from the audience were taken.
    1. Efforts to address misinformation on social media have special urgency with the emergence of coronavirus disease (COVID-19). In one effort, the World Health Organization (WHO) designed and publicized shareable infographics to debunk coronavirus myths. We used an experiment to test the efficacy of these infographics, depending on placement and source. We found that exposure to a corrective graphic on social media reduced misperceptions about the science of 1 false COVID-19 prevention strategy but did not affect misperceptions about prevention of COVID-19. Lowered misperceptions about the science persisted >1 week later. These effects were consistent when the graphic was shared by the World Health Organization or by an anonymous Facebook user and when the graphics were shared preemptively or in response to misinformation. Health organizations can and should create and promote shareable graphics to improve public knowledge.
    1. This episode of #StratComTalks​ looks at how this disinformation spreads vis-à-vis vaccination and how governments can prepare for this communications challenge.
    1. If you are interested in QAnon, QAnonCasualties is a must subreddit to read regularly and to get to know what is happening in QWorld from those closest to QAnon adherents.
    1. If you are interested in QAnon, QAnonCasualties is a must subreddit to read regularly and to get to know what is happening in QWorld from those closest to QAnon adherents.
  3. Feb 2021
    1. For weeks, the public messages about vaccines have been more negative than the facts warrant. Now we are seeing the cost: A large percentage of Americans wouldn't take a vaccine if offered one.
    1. Is this lockdown 3.0 as tough as lockdown 1? Here are a few pieces of data from the @IndependentSage briefing which suggest that despite tackling a much more transmissible virus, lockdown is less strict, which might explain why we are only just keeping on top of cases.
    1. Periodic reminder that in terms of outcomes, Swedish corona policy is thoroughly average in EU comparison – not exactly a model to be emulated by the rest of the world, nor a crime against humanity that should be prosecuted in the Hague.
    1. Vaccine efficacy in blocking infection & transmission (I think) We can now estimate the (minimum) reduction in transmission from the Moderna vaccine. Thread tl;dr Moderna vaccine blocks >90% (87-93%) of infections & 91% (89-94%) of transmission. *Critiques welcome!
    1. I've spoken to 2,000+ companies over the last 12 months about their plans for remote work going forward Here are a few things I've learned
    1. The Government Communication Service (GCS) has published a new piece of guidance titled ‘The principles of behaviour change communications’.
  4. Aug 2020
    1. In response to COVID-19, dramatic safer-​at-home policies were im­ple­mented. The un­der­stand­ing of their impacts on social dis­tanc­ing, travel and pollution is in its infancy. We pair a differences-​in-differences framework and synthetic control methods with rich cellular tracking and high frequency air pollution data. We find that state and U.S. county safer-​at-home policies are suc­cess­ful in en­cour­ag­ing social distance; beginning the day of the policy trips outside the home are sharply decreased while time in residence rises sharply. With less vehicle traffic, we find: a 50% reduction in vehicular col­li­sions; an ap­prox­i­mately 25% reduction in Par­tic­u­late Matter (PM2.5) con­cen­tra­tions; and a reduction of the incidence of county-​days with an air quality index of code yellow or above by two-​thirds. We calculate that the benefits from avoided car col­li­sions could range from $7 billion to $24 billion while the benefits from reduced pollution could range from $650 million to $13.8 billion.